HIGH SPEED ODT FOR IMAGING BLOOD FLOW DYNAMICS & TISSUE STRUCTURE

用于血流动力学成像的高速 ODT

• 批准号: 7954746
• 负责人: ZHONGPING CHEN
• 金额: $ 0.3万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7954746
• 关键词: Anatomy; Animal Model; Biological; Biomedical Research; Biotechnology; Blood; Blood flow; Canis familiaris; Clinical Medicine; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Computer software; Development; Diagnosis; Diagnostic; Disease Management; Funding; Grant; Image; Imagery; Imaging Techniques; In Vitro; Institution; Laboratories; Lasers; Microcirculation; Monitor; Noise; Operative Surgical Procedures; Optical Coherence Tomography; Optics; Patients; Penetration; Phase; Physicians; Physiology; Port-Wine Stain; Research; Research Personnel; Resolution; Resources; Skin Neoplasms; Source; Speed; Structure; System; Techniques; Technology; Tissues; United States National Institutes of Health; chorioallantoic membrane; clinical application; computerized data processing; design; hemodynamics; image reconstruction; in vivo; membrane model; reconstitution; tomography; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Direct visualization of tissue physiology and anatomy provides important information to the physician for the diagnosis and management of disease. High spatial resolution noninvasive techniques for imaging in vivo tissue structure and blood flow dynamics are currently not available as a diagnostic tool in clinical medicine. Such techniques could have a significant impact for biomedical research and patient treatment. The objective of the proposed research is to develop a high speed noninvasive optical technique, optical coherence tomography (OCT) and optical Doppler tomography (ODT), for imaging in vivo tissue structure and blood flow with high spatial resolution (2-10 5m) in biological tissues. Preliminary results obtained in our laboratory have demonstrated the potential of this technology for a number of clinical applications where imaging tissue structure and monitoring hemodynamics are important. However, there are four limitations in our current OCT/ODT s yste m: speed, resolution, penetration depth and speckle noise. The proposed research is directed toward the development of a high speed, high resolution, phase resolved OCT/ODT system for imaging tissue structure and microcirculation that overcomes these limitations. The specific aims of this proposal are to: (1) design and develop a high speed high resolution phase resolved OCT/ODT system for tomographic imaging of in vivo tissue structure and blood flow dynamics in highly scattering biological tissues; (2) develop signal processing and image reconstruction software and hardware for phase resolved OCT/ODT; (3) image blood flow in vitro using reconstituted canine blood and in vivo using the chick chorioallantoic membrane (CAM) model to verify and optimize OCT/ODT system operation and spatial resolution; and (4) demonstrate in animal models and clinical studies how OCT/ODT can assist in diagnosis and treatment of skin tumors and port wine stain birthmarks where imaging tissue structur e and monitoring blood flow are important.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 组织生理和解剖结构的直接可视化为医师提供了重要信息，以诊断和管理疾病。 当前，用于体内组织结构和血流动力学成像的高空间分辨率非侵入性技术目前尚不可作为临床医学的诊断工具。 这种技术可能对生物医学研究和患者治疗产生重大影响。 拟议的研究的目的是开发高速非侵入性光学技术，光学相干断层扫描（OCT）和光学多普勒断层扫描（ODT），用于在生物组织中具有高空间分辨率（2-10 5M）的体内组织结构和血流成像。 在我们的实验室中获得的初步结果证明了这项技术对许多临床应用的潜力，在许多临床应用中，成像组织结构和监测血液动力学很重要。 但是，我们当前的OCT/ODT S YSTE M有四个局限性：速度，分辨率，穿透深度和斑点噪声。 拟议的研究针对高速，高分辨率，相位解析的OCT/ODT系统，用于成像组织结构和微循环，从而克服了这些局限性。 该建议的具体目的是：（1）设计和开发高速高分辨率阶段解析OCT/ODT系统，用于在高度散射生物组织中的体内组织结构和血流动力学的层析成像； （2）为相位解决的OCT/ODT开发信号处理和图像重建软件和硬件； （3）使用重构犬血和体内的体外图像血流在体外使用小鸡绒毛膜膜（CAM）模型在体外进行验证和优化OCT/ODT系统操作和空间分辨率； （4）在动物模型和临床研究中证明了OCT/ODT如何帮助诊断和治疗皮肤肿瘤和港口葡萄酒染色胎记，其中成像组织结构和监测血流很重要。