PHYSIOLOGICAL/BEHAVIORAL EFFECTS OF SOCIAL INTRO ON ADULT MALE RHESUS MACAQUES

社交介绍对成年雄性恒河猴的生理/行为影响

• 批准号: 7958673
• 负责人: KATE CANFIELD BAKER
• 金额: $ 6.01万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958673
• 关键词: Adult; Anxiety; Behavior; Behavioral; Categories; Computer Retrieval of Information on Scientific Projects Database; Data; Devices; Distress; Funding; Grant; Heart Rate; Housing; Hydrocortisone; Implant; Institution; Laboratories; Lead; Locomotion; Macaca; Macaca mulatta; Measures; Methods; Monitor; Phase; Physiological; Primates; Process; Research; Research Personnel; Resources; Risk; Source; Stress; Time; United States National Institutes of Health; depressive symptoms; design; experience; falls; indexing; male; psychologic; social; wound

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: Pair housing of laboratory macaques is widely considered to lead to positive changes in wellbeing, yet the process of introduction is viewed as potentially stressful and risk-prone. Methods: Behavioral and physiological data were collected on eight adult male rhesus macaques before, during, and after the process of introduction, in order to measure the initial stress of introduction as well as long-term changes in wellbeing. Socially experienced subjects, all implanted with biotelemetry devices, were studied in five successive phases: baseline (singly housed), one day each of protected contact and full contact introduction, post-introduction (1-3 weeks after introduction), and settled pairs (e20 weeks after introduction). 176 h of behavioral data and 672 h of heart rate data were analyzed. Fecal cortisol was also measured for the baseline, post-introduction and settled pair phases. Results/Discussion: All introductions were successful and subjects showed no physiological or behavioral signs of stress, such as increased heart rate, abnormal behavior, or psychological indices of distress (depressive/anxiety-related behavior). Agonism was minimal throughout the introduction process and over subsequent months; only one wound was incurred over the course of the study. Levels of abnormal behaviors, psychological indices of distress, locomotion, inactivity, and affiliation showed improvements within several weeks after introduction; these changes were still present 5-9 months later for the latter two categories. Heart rates during introduction fell significantly in the settled pair phase, and also varied predictably with time of day. Fecal cortisol levels were lower in settled pairs than in single housing. The fact that reductions in abnormal behavior did not persist over long-term may have been confounded by increasing duration of time spent caged. Results of this study may be of practical use for designing and monitoring social introductions and suggest that managers should not dismiss feasibility of successful pairing of adult male rhesus macaques.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 背景：实验室猕猴的配对饲养被广泛认为可以带来健康状况的积极变化，但引入的过程被认为具有潜在的压力和风险。 方法：收集了八只成年雄性恒河猴在引入过程之前、期间和之后的行为和生理数据，以测量引入过程中的初始压力以及健康状况的长期变化。 具有社交经验的受试者，全部植入生物遥测设备，分五个连续阶段进行研究：基线（单独饲养）、受保护接触和完全接触引入各一天、引入后（引入后 1-3 周）和定居配对（ e20 周后引入）。 分析了 176 小时的行为数据和 672 小时的心率数据。 还测量了基线、引入后和稳定配对阶段的粪便皮质醇。结果/讨论：所有介绍都很成功，受试者没有表现出压力的生理或行为迹象，例如心率加快、行为异常或痛苦的心理指标（抑郁/焦虑相关行为）。 在整个引入过程和随后的几个月里，激动情绪是最小的；在研究过程中仅造成一处伤口。 引入后几周内，异常行为水平、痛苦、运动、不活动和归属感等心理指标均有所改善；对于后两类，这些变化在 5-9 个月后仍然存在。 引入期间的心率在稳定配对阶段显着下降，并且也随着一天中的时间而发生可预测的变化。 成对居住的粪便皮质醇水平低于单人居住。 事实上，异常行为的减少并没有长期持续下去，这一事实可能与笼中时间的增加相混淆。这项研究的结果可能对设计和监测社会介绍有实际用途，并建议管理者不应忽视成年雄性恒河猴成功配对的可行性。