SOCIAL HOUSING AND SIV DISEASE

社会住房和 SIV 疾病

• 批准号: 8358127
• 负责人: KATE CANFIELD BAKER
• 金额: $ 5.78万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358127
• 关键词: Adult; Animal Care and Use Committees; Animals; Behavioral; Biomedical Research; Clinical Data; Code; Data; Data Collection; Development; Disease; Disease Progression; Funding; Grant; Housing; Individual; Infection; Macaca mulatta; Measures; Methods; National Center for Research Resources; Physiological; Physiology; Primates; Principal Investigator; Protocols documentation; Quality of life; Research; Research Infrastructure; Research Subjects; Resources; SIV; Schedule; Source; Study Subject; United States National Institutes of Health; Vaccines; Videotape; Virus Diseases; cost; meetings; member; nonhuman primate; prophylactic; psychologic; sex; social

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Introduction. Nonhuman primates used in biomedical research can be provided the best quality of life if their management takes their disease status into consideration. For example, it is important to understand how to best meet the social needs of primates throughout the progression of the Simian Immunodeficiency Virus disease. This study aims to 1) characterize the changes in psychological wellbeing associated with Simian Immunodeficiency Virus disease progression, 2) determine the correspondence between measures of wellbeing and disease-related changes in physiology, and 3) identify any threshold behavioral or physiological values that should be used to trigger either increased scrutiny of compatibility or alterations in the social setting of research subjects. Methods. Subjects include adult, Indian-origin rhesus macaques assigned to research protocols involving SIV infection and anticipated development of SIV disease (i.e. not subject to vaccines, other prophylactic measures, or experimental treatments). The total number of subjects studied will be 32 of each sex. Using behavioral, physiological, immunological and clinical data, changes within individuals are assessed. In addition, effects of pair- versus single housing is being compared. Videotaped data collection begins prior to social introduction and SIV inoculation in order to document baseline profiles in single housing, and is repeated after introduction into pair housing and prior to infection. Within pairs, both members are inoculated on the same day. After inoculation, data are collected intensively for the first month. After the first month, a steady scheduling of less intensive data collection is followed until the endpoints approved by the Animal Care and Use Committee are reached. Results/Discussion. Twelve animals reached study endpoints and data coding has been initiated.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 介绍。 如果对用于生物医学研究的非人类灵长类动物的管理考虑到它们的疾病状况，则可以为其提供最好的生活质量。 例如，了解如何在猿猴免疫缺陷病毒疾病的整个发展过程中最好地满足灵长类动物的社会需求非常重要。 本研究的目的是 1) 描述与猿猴免疫缺陷病毒疾病进展相关的心理健康变化，2) 确定健康测量与疾病相关生理变化之间的对应关系，3) 确定应用于引发对研究对象的兼容性或社会环境的改变进行更严格的审查。 方法。 受试者包括成年印度恒河猴，这些猕猴被分配到涉及 SIV 感染和预期 SIV 疾病发展的研究方案（即不接受疫苗、其他预防措施或实验性治疗）。 研究对象总数为男女各 32 人。 使用行为、生理、免疫和临床数据来评估个体的变化。 此外，正在比较成对住房与单一住房的影响。 录像数据收集在社会引入和 SIV 接种之前开始，以记录单个住房中的基线概况，并在引入配对住房后和感染之前重复进行。 在成对的情况下，两名成员在同一天接种。 接种后，在第一个月集中收集数据。 第一个月后，将按照稳定的安排进行不太密集的数据收集，直到达到动物护理和使用委员会批准的终点。 结果/讨论。 十二只动物达到了研究终点，数据编码已经启动。