Tumor Imaging

肿瘤影像

• 批准号: 7900744
• 负责人: Michael M. Graham
• 金额: $ 2.25万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7900744
• 关键词: Adenovirus Vector; Animals; Bronchoscopy; Cancer Biology; Cancer Center; Cancer Center Support Grant; Cancer Detection; Code; Collaborations; Color; Complementary DNA; Databases; Development; Diagnosis; Diagnostic Imaging; Ensure; Funding; Goals; Grant; Head and neck structure; Image; Iowa; Malignant neoplasm of lung; Medical Imaging; Metabolic; Metabolism; Molecular Target; Nature; Neural Crest; Neuroendocrine Tumors; Neurosecretory Systems; Oxidative Stress; Pediatric Neoplasm; Positron-Emission Tomography; Radioisotopes; Radiosensitization; Reporter Genes; Research; Research Peer Review; Screening procedure; Somatostatin Receptor; Sulfhydryl Compounds; System; Therapeutic Effect; Therapy Clinical Trials; Universities; anticancer research; cancer diagnosis; cancer imaging; cancer therapy; cellular imaging; college; gene therapy; instrumentation; lung cancer screening; melanoma; member; molecular imaging; novel strategies; programs; public-private partnership; response; sodium-iodide symporter; tool; trafficking; tumor

Research in the Tumor Imaging Program extends from imaging in animals geared towards helping expand our understanding of cancer biology, to the use of medical imaging on the diagnosis and assessment of response to therapy of tumors. The overall goal of the members of this program is to develop new approaches to use medical imaging in cancer research and to extend current imaging capabilities to optimize diagnosis and assessment of response to therapy. There are five major overlapping themes within the umbrella of the Program's research. Theme 1 - Diagnostic Imaging Theme 2 - Assessment of Response to Therapy by Imaging Theme 3 - Reporter Gene Imaging Theme 4 - Imaging Parameters Indicative of Metabolic Oxidative Stress Theme 5 - Imaging of Cell Trafficking Major accomplishments of the Tumor Imaging Program include (a) Discovery that 2DG-induced radiosensitization involved disruptions in thiol metabolism supporting the hypothesis that metabolic oxidative stress could be involved with the therapeutic effects of 2DG during cancer therapy, (b) Discovery that gene therapy using an adenovirus vector containing a cDNA coding for the sodium iodide symporter could be utilized to concentrate radionuclides in tumors, and (c) Significant contributions to our understanding of lung cancer diagnosis extending from development of novel approaches to lung cancer imaging through extensive participation in the lung cancer early detection trial. There are numerous past and present productive collaborations both between members of the Program, and with members of other Cancer Center programs. The interactive nature of the Program is illustrated by the "Molecular Imaging of Responses to Cancer Therapy" program supported by an NCI P20 and successful shared instrumentation grants to obtain a Micro- PET machine and SPECT-CT. The program consists of 25 members from 7 departments and 2 colleges. Peer-reviewed, research funding for this program totals $5,878,362 with $1,486,243 coming from the NCI.

肿瘤成像程序中的研究从适合扩大我们的动物的成像扩展 了解癌症生物学，用于诊断和评估医学成像 进行肿瘤的治疗。该计划成员的总体目标是开发新的使用方法 癌症研究中的医学成像并扩展当前的成像功能以优化诊断和 评估对治疗的反应。在伞上有五个主要重叠主题 计划的研究。 主题1-诊断成像 主题2-通过成像评估对治疗的反应 主题3-记者基因成像 主题4-指示代谢氧化应激的成像参数 主题5-细胞贩运的成像 肿瘤成像计划的主要成就包括（a）发现2DG诱导的 放射敏化涉及硫醇代谢的破坏，该假设是代谢氧化的假设 应力可能与癌症治疗过程中2DG的治疗作用有关，（b）发现基因 使用含有碘化钠钠cDNA编码的腺病毒载体的治疗可能是 用于在肿瘤中浓缩放射性核素，以及（c）我们对肺的理解有重要贡献 癌症诊断从新的方法发展到肺癌成像的新方法延伸到广泛 参加肺癌早期检测试验。有许多过去和现在的生产力 该计划成员之间以及其他癌症中心计划的成员之间的合作。 该程序的互动性通过“对癌症的反应的分子成像进行说明 NCI P20和成功共享仪器赠款支持的治疗计划，以获得微观 宠物机器和spect-ct。该计划由来自7个部门和2所大学的25名成员组成。 该计划的同行评审，研究资金总计$ 5,878,362，NCI来自$ 1,486,243。