Molecular Imaging of Responses to Cancer Therapy

癌症治疗反应的分子成像

• 批准号: 6656223
• 负责人: Michael M. Graham
• 金额: $ 40万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-06-06 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6656223
• 关键词: bioimaging /biomedical imaging; imaging /visualization /scanning; neoplasm /cancer therapy

DESCRIPTION: (provided by applicant) The goal of this Pre-ICMIC planning effort is to bring clinical oncologists, basic scientists, and imaging scientists together to develop new research collaborations. This will be through weekly seminars and monthly research retreats. These interdisciplinary collaborations are likely to lead to novel and significant advances in the use of imaging in caring for cancer patients. We intend to particularly emphasize the use of imaging in evaluating cancer therapy. Medical imaging, with X-rays, CT, MRI, PET, and nuclear medicine scans, has been used successfully for many years in diagnosing cancer. It has been used for evaluating therapy, but in a very unsophisticated way; simply determining if a tumor has increased or decreased in size. There are far more sensitive ways to determine tumor viability including measurements of blood flow, oxygenation, metabolism, and membrane integrity. There are also methods to evaluate delivery of drugs to tumors, by labeling with radioactive or magnetic tracers and imaging with PET or MRI. We intend to discuss and possibly study many of these approaches. Gene therapy is an area of specific focus. There is strong support for studies in this area and we plan to take advantage of the existing Gene Transfer Vector Core and Center for Gene Therapy of Cystic Fibrosis and Other Genetic Diseases that are active centers at the University of Iowa. There is strong institutional support for oncology research in general. The University of Iowa recently was designated an NCI Cancer Center. This designation helps solidify and strengthen our commitment to cancer research. An unusual resource within the Department of Radiology is the section of Free Radical and Radiation Biology. This is a strong research group with a specific interest in using gene therapy. This interest has led to work with the iodine symporter gene as a reporter gene and the possibility of imaging it with a wide variety of iodine isotopes and iodine analogs. Three of the potential developmental projects are involved with this reporter gene: in validating its use in vivo, its use for tracking insertion of a gene for manganese superoxide dismutase, a free radical scavenger, and for tracking insertion and expression of p53 injected into tumors by sub-selective catheterization. We also intend to explore the use of novel heavy metal labels to follow viral vector delivery with MRI and CT. PET imaging of F18 fluorothymidine will be used as a way to assess the response to chemotherapy very early after treatment. Tumor glucose metabolism will be imaged to assess oxidative stress and as an indicator of tumor susceptibility to treatment.

描述：（申请人提供） 这项预科计划的目标的目的是带来临床肿瘤学家， 基础科学家和成像科学家一起发展新的研究 协作。这将通过每周的研讨会和每月研究 撤退。这些跨学科的合作可能会导致新颖 在照顾癌症患者中使用成像的显着进步。 我们打算特别强调使用成像在评估癌症中 治疗。医学成像，X射线，CT，MRI，PET和核医学 扫描已成功用于诊断癌症。它有 用于评估治疗，但以一种非常不老练的方式；简单地 确定肿瘤的大小是否增加或减小。还有更多 确定肿瘤生存能力的敏感方法，包括血液的测量 流动，氧合，代谢和膜完整性。还有方法 通过标记放射性或 磁性示踪剂和宠物或MRI成像。我们打算讨论和 可能研究许多这样的方法。基因疗法是特定的领域 重点。在这一领域有强烈的支持，我们计划接受 现有基因转移矢量核心和基因中心的优势 囊性纤维化和其他活性中心的遗传疾病的治疗 在爱荷华大学。对肿瘤学有强烈的机构支持 一般研究。爱荷华大学最近被指定为NCI 癌症中心。该名称有助于巩固和加强我们的承诺 进行癌症研究。放射学系中的一种不寻常的资源是 自由基和辐射生物学的部分。这是一项强大的研究 对使用基因治疗具有特定兴趣的组。这种兴趣导致了 与碘的共物基因一起作为记者基因和可能性 用各种碘同位素和碘类似物对其进行成像。三个 潜在的发展项目与该记者基因有关： 验证其在体内的使用，用于跟踪基因插入基因的使用 锰超氧化物歧化酶，自由基清除剂和跟踪 p53插入和表达通过亚选择性注射到肿瘤中 导管插入。我们还打算探索新型重金属标签的使用 遵循使用MRI和CT的病毒载体传递。 F18的宠物成像 氟氨酰胺将用作评估化学疗法反应的一种方式 治疗后很早。肿瘤葡萄糖代谢将成像以评估 氧化应激，并作为肿瘤易感性治疗的指标。