Imaging Core

成像核心

基本信息

批准号：
10647669
负责人：
EDWARD J DELIKATNY
金额：
$ 21.36万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-06-16 至 2027-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10647669
关键词：
Animals Antigens Back Benchmarking Biodistribution Biopsy Biopsy Specimen Bronchoscopy Calibration Cancer Patient Cancerous Canis familiaris Carcinoma in Situ Clinic Clinical Clinical Trials Communities Contrast Media Data Data Analyses Data Collection Dedications Deposition Detection Development Devices Diagnostic Drug Kinetics Dyes Equipment Excision Faculty Fibroblasts Fluorescence Goals Histopathology Human Image Image-Guided Surgery In Situ Location Lung Lung Neoplasms Lymph Node Dissections Maintenance Malignant Neoplasms Malignant neoplasm of lung Measurement Methods Micrometastasis Microscope Microscopic Microscopy Mission Modeling Mus Near-infrared optical imaging Neoplasm Metastasis Nodule Non-Small-Cell Lung Carcinoma Operative Surgical Procedures Optical Biopsy Optics Outcome Pathology Patients Prognosis Program Research Project Grants Protocols documentation Radiology Specialty Resolution Resources Sampling Sensitivity and Specificity Series Specimen Surgical Management Surgical Pathology Techniques Testing Tissue imaging Tracer Training Translating Translations Veterinary Schools animal imaging cancer clinical trial cancer imaging carbonate dehydratase clinical imaging computerized data processing design digital pathology ex vivo imaging fibroblast-activating factor fluorescence imaging human imaging imaging agent imaging facilities imaging platform imaging study imaging system improved instrumentation lymph node biopsy lymph nodes medical schools microscopic imaging molecular imaging novel optical imaging pre-clinical preclinical imaging programs targeted imaging tissue processing tumor tumor microenvironment

项目摘要

Project Summary/Abstract The Imaging Core (Core B) provides centralized imaging support to all levels of this Program Project grant, from small animals to human imaging. The Core combines resources from the Small Animal Imaging Facility in Radiology, the Matthew J Ryan Veterinary School of Medicine and the Center for Precision Surgery to create a facility with state-of-the-art instrumentation, and dedicated faculty and staff to apply NIR optical imaging to intraoperative pulmonary surgery. The Core will focus on developing and implementing back table imaging protocols for fluorescence imaging of tumors in situ and in surgical specimens. The goals are to improve co- registration of fluorescence images with histopathology, accurately determine tumor margin detection and detect micrometastases, secondary tumor deposits and cancerous lymph nodes. We will apply these techniques to pulmonary tumor resections, bronchoscopies, and lymph node specimens. In addition, Core B will provide imaging support to both large animal (canine) and small animal (mouse) components of this program to aid in the translation of the new novel targeted imaging agents into the operating theater in patients with pulmonary cancers. Part of the mission of the Core is to refine tissue processing protocols in order to co-register macro and microscopic tissue images between surgical images and pathology. In doing so we will compare the sensitivity and resolution of different imaging platforms and determine the sensitivity of NIR imaging and the depth of detectable fluorescence. The Core facilitates testing of new imaging cameras, calibrating against fluorescent standards and phantoms, and benchmarking to existing clinical and preclinical imaging scanners. Our goal is to establish a paradigm bridging surgical imaging and pathology for the establishment of an optical biopsy for precise detection of margins in the operating theater. These advances will improve the surgical management and prognosis of lung cancer patients.

项目概要/摘要成像核心（核心 B）为本计划项目拨款的各个级别提供集中成像支持，从小动物到人类成像。该核心结合了小动物成像设施的资源放射学、马修·J·瑞安兽医医学院和精密外科中心创建了一个配备最先进的仪器和专门的教职员工，将近红外光学成像应用于术中肺部手术。核心将专注于开发和实施后台成像原位肿瘤和手术标本荧光成像方案。目标是改善合作荧光图像与组织病理学配准，准确判断肿瘤边缘检测并检测微转移、继发性肿瘤沉积和癌性淋巴结。我们将应用这些技术肺部肿瘤切除术、支气管镜检查和淋巴结标本。此外，Core B 将提供对该计划的大型动物（犬）和小动物（小鼠）部分提供成像支持，以帮助将新型靶向显像剂引入手术室治疗肺结核患者癌症。核心任务的一部分是完善组织处理协议，以便共同注册宏以及介于手术图像和病理之间的显微组织图像。在此过程中，我们将比较不同成像平台的灵敏度和分辨率，并确定近红外成像的灵敏度和可检测荧光的深度。该核心有助于测试新的成像相机，并根据荧光标准和模型，以及现有临床和临床前成像扫描仪的基准测试。我们的目标是建立一个连接手术成像和病理学的范例，以建立光学活检以在手术室中精确检测切缘。这些进步将改善手术肺癌患者的管理和预后。