NIR ENZYME-ACTIVATED FLUOROGENIC PHOSPHOLIPIDS FOR MULTI-MODALITY IMAGING

用于多模态成像的近红外酶激活荧光磷脂

• 批准号: 8361955
• 负责人: EDWARD J DELIKATNY
• 金额: $ 0.77万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361955
• 关键词: Diagnostic; Disease Management; Early Diagnosis; Enzymes; Funding; Goals; Grant; Hydrolysis; Lead; Lipids; Magnetic Resonance; Magnetic Resonance Spectroscopy; Malignant Neoplasms; Membrane; Methods; Molecular Probes; National Center for Research Resources; Pathologic Processes; Phospholipase; Phospholipid Metabolism; Phospholipids; Physiological Processes; Principal Investigator; Research; Research Infrastructure; Resources; Second Messenger Systems; Signal Pathway; Signal Transduction; Source; United States National Institutes of Health; chemotherapy; cost; imaging modality; improved; in vivo; molecular imaging; novel; optical imaging; second messenger

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Phospholipases catalyze the hydrolysis of membrane phospholipids, which, in turn, generates a variety of lipid second messengers. These lipid-derived products are necessary for both physiological and pathological processes. An understanding of phospholipid metabolism, as it relates to cancer, is necessary for diagnostic applications and for developing novel targeted chemotherapy. Traditionally, lipid metabolite changes have been observed by magnetic resonance spectroscopy (MRS) or by chromatographic methods. Using a combination of MRS with near-infrared (NIR) fluorescent molecular probes we are targeting phospholipase function with the goal of delineating specific cell signaling pathways in vivo. The information gained from a molecular imaging approach may lead to earlier diagnoses and improved management of disease.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 磷脂酶催化膜磷脂的水解，从而产生A 多种脂质第二使者。这些脂质衍生的产品对于两者都是必要的 生理和病理过程。对磷脂代谢的理解 与癌症有关，对于诊断应用和开发新颖的目标是必需的 化学疗法。传统上，通过磁性观察到脂质代谢产物的变化 共振光谱（MRS）或通过色谱方法。结合 MRS具有近红外（NIR）荧光分子探针，我们靶向磷脂酶 功能的目的是在体内描述特定的细胞信号通路。信息 从分子成像方法中获得的可能会导致较早的诊断并改善 疾病管理。