SICKLE CELL NUTRITION

镰状细胞营养

• 批准号: 7960784
• 负责人: JACQUELINE M HIBBERT
• 金额: $ 0.98万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7960784
• 关键词: Address; Adult; Affect; African American; Age; Amino Acids; Anti-Inflammatory Agents; Anti-inflammatory; Antioxidants; Arginine; Body Composition; Body Weight; Characteristics; Child; Chronic; Clinical; Computer Retrieval of Information on Scientific Projects Database; Deposition; Diet; Disease; Effectiveness; Energy Metabolism; Essential Amino Acids; Funding; General Population; Grant; Growth; Growth and Development function; Health; Healthcare; Height; Hematological Disease; Hemoglobin; Hospitalization; Immune; Individual; Inflammation; Inherited; Institution; Longevity; Malnutrition; Measures; Minority; Morbidity - disease rate; Nitric Oxide; Nutritional Requirements; Nutritional Study; Oxidants; Pain; Pathology; Production; Proteins; Research; Research Personnel; Resources; Rest; Reticulocyte count; Sickle Cell; Sickle Cell Anemia; Source; Symptoms; Testing; Tissues; United States National Institutes of Health; Weight; base; blood vessel occlusion; cost; dietary supplements; improved; indexing; meetings; protein degradation; repaired

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Sickle cell anemia (HbSS) is a global health problem, which, in the USA, affects mainly Americans of African descent, who are also likely to be affected by health care disparities and high clinical costs. The most characteristic symptom of this genetically inherited blood disorder is pain crisis, resulting from vaso-occlusion of blood vessels, and often requiring hospitalization. HbSS is associated with poor growth and development, a deficit of weight for height in adults and general morbidity, including poor immune status and chronic subclinical inflammation. All these symptoms are indicators of undernutrition. We hypothesize that the characteristicdeficits in growth and development result from greater energy and protein needs for individuals with the disease than for the general population, and that these requirements are not met by a diet that is adequate for healthy people. The increased energy needs arise because the shortened life span of the "sickled" erythrocytes accelerates hemoglobin synthesis and hence, whole body protein turnover. The increased protein turnover is associated with an increased net loss of protein and thus increased protein requirement, with particular emphasis on amino acids essential for growth, repair, replacement and healthy antioxidant and anti-inflammatory status. Based on this hypothesis, a natural proposition is that extra energy and protein supplements to the daily diet, will satisfy the extra nutrient requirements, including essential amino acids for optimal lean tissue deposition and repair, increased antioxidant supply and reduced inflammation, eg L-arginine for nitric oxide (NO) production; thereby normalizing body weight, body composition and improving clinical condition. The approach to testing this hypothesis will be two-fold encompassing the following specific aims: 1. to develop an appropriate supplement directly addressing the malnutrition in HbSS pathology and 2. to investigate the effectiveness of the dietary supplement in undernourished HbSS children, aged 9 to 12 y, and adults 18+ y, by measuring changes (over 4 months) in resting energy expenditure, circulating reticulocyte count (an index of RBC production), body composition, circulating amino acids, markers of oxidant damage and pro- and anti-inflammatory proteins associated with NO production.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 镰状细胞贫血（HBSS）是一个全球健康问题，在美国，这主要影响非洲血统的美国人，他们也可能受到医疗保健差异和高临床成本的影响。这种遗传遗传性血液疾病的最特征性症状是疼痛危机，这是由于血管的血管咬合而引起的，通常需要住院。 HBSS与生长和发育不良，成人身高的体重不足以及一般发病率有关，包括免疫状态和慢性亚临床炎症。所有这些症状都是营养不良的指标。我们假设，生长和发育中的特征缺陷是由于对疾病患者的能量和蛋白质需求的增长而不是对普通人群而产生的，并且对健康人的饮食不足以满足这些需求。出现增加的能量需要，因为“谨慎”的红细胞的寿命缩短会加速血红蛋白的合成，从而加速了全身蛋白质的寿命。增加的蛋白质周转率与蛋白质的净损失增加有关，从而增加蛋白质需求，并特别强调氨基酸对于生长，修复，替代以及健康的抗氧化剂和抗炎状态所必需的氨基酸。基于这一假设，一个自然的主张是，每日饮食中的额外能量和蛋白质补充剂将满足额外的养分需求，包括用于最佳瘦肉组织沉积和修复的必需氨基酸，抗氧化剂供应增加和炎症减少，例如，氮氧化物（NO）生产；从而使体重，身体成分和改善临床状况归一化。 The approach to testing this hypothesis will be two-fold encompassing the following specific aims: 1. to develop an appropriate supplement directly addressing the malnutrition in HbSS pathology and 2. to investigate the effectiveness of the dietary supplement in undernourished HbSS children, aged 9 to 12 y, and adults 18+ y, by measuring changes (over 4 months) in resting energy expenditure, circulating reticulocyte count (an index of RBC生产），身体成分，循环 氨基酸，氧化剂损伤的标志物以及与无生产相关的促抗炎蛋白。