DIETARY SUPPLEMENT FOR MANAGING NUTRITIONAL DEFICIENCIES IN SICKLE CELL DISEASE

用于治疗镰状细胞病营养缺乏症的膳食补充剂

• 批准号: 8359891
• 负责人: JACQUELINE M HIBBERT
• 金额: $ 29.1万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8359891
• 关键词: Address; Amino Acids; Anthropometry; Anti-Inflammatory Agents; Anti-inflammatory; Biological Assay; Body Composition; Child; Clinical Research; DEXA; Energy Metabolism; Funding; Grant; Height; Indirect Calorimetry; Inflammatory; Malnutrition; Measurement; Measures; National Center for Research Resources; Oxidants; Pathology; Principal Investigator; Proteins; Research; Research Infrastructure; Resources; Rest; Reticulocyte count; Roentgen Rays; Sickle Cell Anemia; Source; Supplementation; Translational Research; United States National Institutes of Health; Weight; abstracting; base; cost; dietary supplements; efficacy testing; protein metabolism; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Abstract of project: Experiments are being conducted to develop an appropriate dietary supplement directly addressing malnutrition in sickle cell anemia (SCA) pathology. A supplementation study conducted over 4 months, will test the efficacy of the supplement. Measurements include indirect calorimetry, anthropometry, body composition by Dual X-Ray Absorptiometry (DEXA) and circulating levels of inflammatory proteins by luminex assay in undernourished children (6  12 y) with SCA and healthy controls. Specific aims are: 1. to develop a customized nutritional supplement for SCA children, based on estimated requirements for excessive protein and energy metabolism plus specific amino acid deficiencies and 2. to investigate the efficacy of the supplement in undernourished SCA children by measuring temporal changes in resting energy expenditure; reticulocyte count; weight, height and body composition; circulating amino acids; markers of oxidant damage; Pro- and anti-inflammatory protein.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 项目摘要： 正在进行实验，以开发适当的饮食补充剂，直接解决镰状细胞贫血（SCA）病理学的营养不良。 进行了4个月的补充研究将测试补充剂的功效。测量包括间接量热法，人体测量法，双重X射线吸收仪（DEXA）的身体组成，以及luminex测定的炎症蛋白循环水平不足的儿童（6 12 y），具有SCA和健康对照。具体目的是： 1。基于对过度蛋白质和能量代谢的估计要求，以及特定的氨基酸缺乏症，并为SCA儿童开发定制的营养补充 2。通过测量静息能量消耗的时间变化来研究补充剂在营养不足的SCA儿童中的功效；网状细胞计数；体重，身高和身体成分；循环氨基酸；氧化剂损伤的标记；促炎和抗炎蛋白。