ROLE OF NUTRITION IN TREATING SICKLE CELL DISEASE

营养在治疗镰状细胞病中的作用

• 批准号: 7376426
• 负责人: JACQUELINE M HIBBERT
• 金额: $ 1.24万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376426
• 关键词: ROLE; NUTRITION; TREATING; SICKLE; CELL

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. These studies will test the hypothesis that routine dietary protein and/ or energy supplementation will improve clinical conditions and reduce morbidity in adults with homozygous sickle cell disease (HbSS). We hypothesize that the characteristic deficit in body weight in HbSS adults. results from greater energy and protein needs for individuals with the disease energy needs arise because the shortened life span of the "sickled" erythrocytes accelerates hemoglobin energy expenditure is ultimately increased. Furthermore, the increased protein turnover is associated with an increased net loss of protein, therefore increasing protein requirement. A corollary to this hypothesis is that dietary protein and/or energy supplementation will proved the extra energy and protein required to maintain elevated rates of protein turnover and energy expenditure, thereby allowing optimal lean tissue deposition and repair. Consequently body weight and body composition will be normalized and clinical condition improved.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。这些研究将检验以下假设：常规饮食蛋白和/或能量补充剂将改善临床状况并减少纯合镰状细胞病（HBSS）成年人的发病率。我们假设HBSS成年人体重的特征不足。由于疾病能量需求的更大能量和蛋白质需求的结果是出现的，因为“谨慎”的红细胞的寿命缩短了寿命，最终会增加血红蛋白能量消耗。此外，增加的蛋白质周转率与蛋白质的净损失增加有关，因此增加了蛋白质的需求。这种假设的推论是，饮食蛋白和/或能量补充剂将证明维持蛋白质更新和能量消耗率升高所需的额外能量和蛋白质，从而允许最佳的瘦肉组织沉积和修复。因此，体重和身体成分将被标准化，并改善临床状况。