Modeling for Heart, Lung, and Blood: From Cell to Organ

心脏、肺和血液建模：从细胞到器官

基本信息

批准号：
7835638
负责人：
JAMES B BASSINGTHWAIGHTE
金额：
$ 23.22万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-04-01 至 2012-03-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): This application, written in response to RFA-HL-07-002, entitled Modeling for Heart, Lung, and Blood: From Cell to Organ, is to provide training in computational modeling for investigators in the spirit of the Physiome effort, which has the goal of developing quantitative biology to improve medical science from genes to health. The program will consist of 2 courses per year, workshops at meetings, web tutorials and modeling, libraries of model programs and modeling systems for free distribution, and individual trainee follow-up training programs. The central mission is to aid investigators in developing expertise in the design of efficient experimental studies and in the analysis of data using integrative physiological models. The courses focus on applying the principles of the scientific method for designing and testing hypotheses and the use of parameterization and categorization of observations for diagnosis and therapy. The coverage ranges from the development of biophysical and biochemical level modules for cellular and subcellular systems, to whole body integrative systems for cardiovascular, respiratory and hematologic systems. Via hands on modeling from the first hour of the course using JSim a powerful but easily learned simulation system handling ordinary and partial differential equations (ODE and PDEs), stochastic models, etc., participants will learn how to examine data in order to develop hypotheses, how to convert ideas into mathematical testable model-hypotheses, how to evaluate the veracity and accuracy of computer solutions, how to design critical experiments using modeling, how to analyze data by optimization techniques providing residuals and confidence ranges for parameters, and how to evaluate validity of hypotheses and iterate the hypothesis-model- experiment-validation loop. Course participants will use software such as JSim, a platform-independent simulation analysis system, and Matlab. They will learn about simulation systems suitable for solving ODEs, Gepasi, XPPAUT, etc. and other tools, e.g. Systems Biology Workbench. Participants may also choose to return for individual training or for collaborative research. Each year the June course will emphasize elemental biophysical, physiological, and biochemical module design and construction, with application to clinical research using integrative models for positron emission tomography or magnetic resonance. Each year the September course will emphasize an application area such as cardiac or respiratory studies. Over the 4-year program we plan to provide courses and individual training for 200 participants to learn in depth, for others to train themselves using our models and tutorials on the web, and for any investigator to take these published models as starting points for their own models. The result should enhance our nation's capabilities in quantitative research analysis and improve our competitiveness in the advancement of diagnostic and therapeutic techniques.

描述（由申请人提供）：该应用程序是针对RFA-HL-07-002的响应，标题为“心脏，肺和血液：从细胞到器官”的建模，是为了为研究人员提供培训，以生理努力的精神为研究人员提供培训，该精神的目标是开发定量生物学，以改善医学科学从基因到健康。该计划将包括每年2个课程，会议，网络教程和建模的研讨会，模型计划的库以及免费分发的建模系统以及单个受训者的后续培训计划。中心任务是帮助研究人员在设计有效的实验研究设计和使用综合生理模型的数据分析方面发展专业知识。这些课程着重于应用科学方法的原理设计和测试假设，并使用参数化和观察结果进行诊断和治疗的分类。覆盖范围从用于细胞和亚细胞系统的生物物理和生化水平模块的开发到心血管，呼吸系统和血液学系统的全身整合系统。通过使用JSIM使用JSIM进行建模的动手进行建模，一种强大但易于学习的模拟系统处理普通和部分微分方程（ODE和PDES和PDE），随机模型等，参与者将学习如何检查数据以开发假设，如何将思想转换为数学可测试的模型，以评估计算机的准确性和计算机的准确性来分析计算机的数据，如何将思想转换为计算机的准确性，如何进行计算机的替代方案，如何分析计算机的质疑，如何进行计算机溶液，如何进行计算机溶液，如何进行计算机的替代方案。为参数提供残差和置信范围，以及如何评估假设的有效性并迭代假设模型实验验证环路。课程参与者将使用JSIM之类的软件，JSIM，独立于平台的仿真分析系统和MATLAB。他们将了解适用于解决ODE，GEPASI，XPPAUT等的模拟系统以及其他工具，例如系统生物学工作台。参与者还可以选择返回个人培训或合作研究。每年，六月课程都会强调元素生物物理，生理和生化模块的设计和构建，并使用集成模型用于正电子发射断层扫描或磁共振上的临床研究。每年9月的课程都会强调一个应用领域，例如心脏或呼吸研究。在为期4年的计划中，我们计划为200名参与者提供课程和个人培训，以深入学习，以便其他人在网络上使用我们的模型和教程进行训练，并让任何调查员以这些已公开的模型为自己的模型的起点。结果应提高我们国家在定量研究分析中的能力，并提高我们在诊断和治疗技术发展方面的竞争力。

项目成果

期刊论文数量（13）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Modeling to link regional myocardial work, metabolism and blood flows.

DOI：
10.1007/s10439-012-0613-5
发表时间：
2012-11
期刊：
ANNALS OF BIOMEDICAL ENGINEERING
影响因子：
3.8
作者：
Bassingthwaighte, James B.;Beard, Daniel A.;Carlson, Brian E.;Dash, Ranjan K.;Vinnakota, Kalyan
通讯作者：
Vinnakota, Kalyan

Compartmental modeling in the analysis of biological systems.