Modeling for Heart, Lung, and Blood: From Cell to Organ

心脏、肺和血液建模：从细胞到器官

基本信息

批准号：
7251831
负责人：
JAMES B BASSINGTHWAIGHTE
金额：
$ 23.22万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-04-01 至 2011-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7251831
关键词：
Actins Action Potentials Address Aerosols Alveolar Alveolus Anatomic Models Anatomy Appendix Archives Area Asthma Basic Science Behavior Binding Biochemical Biochemical Pathway Biological Biological Models Biology Biomedical Engineering Blood Blood Cells Blood Vessels Blood capillaries Bolus Infusion Breathing Carbon Dioxide Cardiac Cardiovascular Models Cardiovascular Physiology Cardiovascular system Cell model Cells Cellular biology Chest wall structure Chronic Obstructive Airway Disease Clinical Clinical Research Code Coffee Collaborations Commit Complex Computer Simulation Computer Systems Computer software Computers Condition Conflict (Psychology)Consumption Convection Critiques Data Data Analyses Data Set Databases Decision Making Dependence Depth Development Diagnosis Diagnostic Diffuse Diffusion Dimensions Disease Drug Delivery Systems Educational process of instructing Educational workshop Elasticity Electronic Mail Electrophysiology (science)Environment Environmental air flow Equation Equilibrium Evaluation Exclusion Excretory function Exercise Exhalation Facility Construction Funding Category Faculty Familiarity Feedback Finite Element Analysis Gases Generations Genes Genetic Genome Goals Grant Graph Hand Health Hearing Heart Hemoglobin Heterogeneity Hodgkin Disease Hour Image Imagery Imaging Techniques Indicator Dilution Techniques Individual Internet Investigation Ion Channel Kidney Kinetics Knowledge Laboratories Language Learning Letters Libraries Life Liquid substance Literature Lung Lung Compliance Magnetic Resonance Magnetic Resonance Imaging Mathematics Measurement Measures Meat Mechanics Medical Membrane Membrane Potentials Metabolic Metabolic Diseases Metabolism Methods Mission Modeling Molecular Conformation Monitor Mucous body substance Myocardial Infarction Myocardial perfusion Myocardium Myosin ATPase Na(+)-K(+)-Exchanging ATPase Nerve Nitric Oxide Noble Gases Numbers Occupational Exposure Organ Oxygen Ozone Paper Partial Liquid Ventilation Participant Perfusion Physics Physiological Physiology Positioning Attribute Positron-Emission Tomography Postdoctoral Fellow Predictive Value Preparation Pressoreceptors Principal Investigator Procedures Process Program Evaluation Programming Languages Proteins Publications Publishing Pulmonary Circulation Pulmonary Pathology Pulmonary alveolar structure Pump Range Rate Reaction Relative (related person)Research Research Personnel Residual state Resistance Respiratory System Running Sarcomeres Schedule Science Score Self Assessment Semantics Series Signal Transduction Simulate Site Solid Solutions Source Standards of Weights and Measures Stress Structure Students Support of Research Surveys System Systems Analysis Systems Biology Techniques Testing Text Therapeutic Time Tissues Training Training Programs Translating Transport Reaction Tube Validation Variant Visit Vital capacity Vocabulary Week Wireless Technology Work Writing analog base capillary chemical reaction clinical application computerized tools concept cost data acquisition data modeling day design design and construction desire discount experience follow-up improved instructor lecturer lectures mathematical model model development multi-scale modeling passive transport phosphoric diester hydrolase platform-independent pressure programs receptor density research and development research study respiratory response simulation single photon emission computed tomography solute surfactant symposium theories tool uptake voltage

项目摘要

DESCRIPTION (provided by applicant): This application, written in response to RFA-HL-07-002, entitled Modeling for Heart, Lung, and Blood: From Cell to Organ, is to provide training in computational modeling for investigators in the spirit of the Physiome effort, which has the goal of developing quantitative biology to improve medical science from genes to health. The program will consist of 2 courses per year, workshops at meetings, web tutorials and modeling, libraries of model programs and modeling systems for free distribution, and individual trainee follow-up training programs. The central mission is to aid investigators in developing expertise in the design of efficient experimental studies and in the analysis of data using integrative physiological models. The courses focus on applying the principles of the scientific method for designing and testing hypotheses and the use of parameterization and categorization of observations for diagnosis and therapy. The coverage ranges from the development of biophysical and biochemical level modules for cellular and subcellular systems, to whole body integrative systems for cardiovascular, respiratory and hematologic systems. Via hands on modeling from the first hour of the course using JSim a powerful but easily learned simulation system handling ordinary and partial differential equations (ODE and PDEs), stochastic models, etc., participants will learn how to examine data in order to develop hypotheses, how to convert ideas into mathematical testable model-hypotheses, how to evaluate the veracity and accuracy of computer solutions, how to design critical experiments using modeling, how to analyze data by optimization techniques providing residuals and confidence ranges for parameters, and how to evaluate validity of hypotheses and iterate the hypothesis-model- experiment-validation loop. Course participants will use software such as JSim, a platform-independent simulation analysis system, and Matlab. They will learn about simulation systems suitable for solving ODEs, Gepasi, XPPAUT, etc. and other tools, e.g. Systems Biology Workbench. Participants may also choose to return for individual training or for collaborative research. Each year the June course will emphasize elemental biophysical, physiological, and biochemical module design and construction, with application to clinical research using integrative models for positron emission tomography or magnetic resonance. Each year the September course will emphasize an application area such as cardiac or respiratory studies. Over the 4-year program we plan to provide courses and individual training for 200 participants to learn in depth, for others to train themselves using our models and tutorials on the web, and for any investigator to take these published models as starting points for their own models. The result should enhance our nation's capabilities in quantitative research analysis and improve our competitiveness in the advancement of diagnostic and therapeutic techniques.

描述（由申请人提供）：此应用程序是根据 RFA-HL-07-002 编写的，题为“心脏、肺和血液建模：从细胞到器官”，旨在本着 Physiome 努力的精神为研究人员提供计算建模培训，该工作具有发展定量生物学的目标是改善从基因到健康的医学科学。该计划将包括每年 2 门课程、会议研讨会、网络教程和建模、免费分发的模型程序和建模系统库以及个人学员后续培训计划。中心任务是帮助研究人员发展有效实验研究设计和使用综合生理模型分析数据的专业知识。这些课程的重点是应用科学方法的原理来设计和检验假设，以及使用参数化和观察分类来进行诊断和治疗。涵盖范围从细胞和亚细胞系统的生物物理和生化水平模块的开发，到心血管、呼吸和血液系统的全身综合系统。通过从课程第一个小时开始使用 JSim 进行动手建模，JSim 是一个功能强大但易于学习的模拟系统，可处理常微分方程和偏微分方程（ODE 和 PDE）、随机模型等，参与者将学习如何检查数据以提出假设，如何将想法转化为数学可检验的模型假设，如何评估计算机解决方案的真实性和准确性，如何使用建模设计关键实验，如何通过提供参数残差和置信范围的优化技术来分析数据，以及如何评估假设的有效性并迭代假设-模型-实验-验证循环。课程参与者将使用 JSim（独立于平台的仿真分析系统）和 Matlab 等软件。他们将学习适合求解 ODE、Gepasi、XPPAUT 等的仿真系统以及其他工具，例如系统生物学工作台。参与者还可以选择返回进行个人培训或合作研究。每年六月的课程将强调基本的生物物理、生理和生化模块设计和构建，以及使用正电子发射断层扫描或磁共振综合模型应用于临床研究。每年九月的课程都会强调一个应用领域，例如心脏或呼吸研究。在为期 4 年的计划中，我们计划为 200 名参与者提供课程和个人培训，让他们深入学习，让其他人使用我们的模型和网络教程进行自我培训，并让任何研究人员以这些已发布的模型作为他们的起点自己的模型。研究结果将增强我国定量研究分析的能力，提高我们在诊断和治疗技术进步方面的竞争力。