Quantifying and Tracking Risk for Substance Use Disorder

量化和跟踪药物使用障碍的风险

• 批准号: 7022916
• 负责人: LEVENT KIRISCI
• 金额: $ 12.42万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7022916
• 关键词: adolescence (12-20); behavioral /social science research tag; case history; child mental disorders; clinical research; developmental psychology; disease /disorder etiology; disease /disorder proneness /risk; family genetics; gene environment interaction; human subject; mathematical model; pathologic process; peer group; psychological tests; psychometrics; questionnaires; racial /ethnic difference; social psychology; statistics /biometry; substance abuse epidemiology; substance abuse related disorder; technology /technique development

DESCRIPTION (provided by applicant): The overarching aim of this Independent Scientist Award (K02) application is to develop skills in genetics and epidemiology, and enhance my expertise in quantitative methodology pertaining to substance use disorder (SUD) etiology. The goal of the research program in the next five years is to integrate statistical and psychometric methods for deriving a practical and valid assessment of SUD liability. Employing item response theory, in conjunction with longitudinal multivariate modeling, the product of the proposed research is a continuous scale that quantifies individual risk for SUD at ages 10-12, 16, 19, and 22. This scale will be a provisionally validated self-administered questionnaire that can be used in routine assessment of youth and young adults for identifying those in need of intervention. Two versions will be developed and compared: paper and pencil for group screening and computer adaptive testing for individual assessment. To achieve this project goal, I will access the Center for Education on Drug Abuse Research (CEDAR) database consisting of multidisciplinary protocols for measurement of SUD risk. In this center grant, where I direct the Methodology and Statistics Core, psychological and environmental risk factors are prospectively studied from childhood to adulthood. The education and training component will prepare me for an R01 that is directed at standardizing the SUD liability scale derived in this research in the context of a genetic epidemiological paradigm. In this manner, etiology from the standpoint of gene-environment interactions will be investigated using the SUD liability scale provisionally derived in this project and simultaneously standardized for practical application. The long-term career goal will thus be to apply my psychometric and statistical expertise to develop instrumentation that clarifies SUD etiology and conjointly has practical utility.

描述（由申请人提供）：本次独立科学家奖（K02）申请的首要目标是培养遗传学和流行病学方面的技能，并增强我在与物质使用障碍（SUD）病因学相关的定量方法方面的专业知识。未来五年研究计划的目标是整合统计和心理测量方法，对 SUD 责任进行实用且有效的评估。采用项目反应理论，结合纵向多元模型，拟议研究的产品是一个连续量表，量化 10-12、16、19 和 22 岁的个体 SUD 风险。该量表将是一个临时验证的自我评估。管理问卷，可用于对青少年和年轻人的常规评估，以确定需要干预的人。将开发和比较两个版本：用于团体筛选的纸和铅笔以及用于个人评估的计算机自适应测试。为了实现该项目目标，我将访问药物滥用研究教育中心 (CEDAR) 数据库，该数据库包含用于测量 SUD 风险的多学科协议。在这个中心拨款中，我指导方法论和统计核心，对从儿童到成年的心理和环境风险因素进行前瞻性研究。教育和培训部分将使我为 R01 做好准备，该 R01 旨在标准化遗传流行病学范式背景下本研究中得出的 SUD 责任量表。通过这种方式，将从基因-环境相互作用的角度来研究病因学，使用本项目中临时导出的 SUD 责任量表，并同时标准化以供实际应用。因此，长期职业目标是运用我的心理测量和统计专业知识来开发能够阐明 SUD 病因并具有实际用途的仪器。