Quantifying and Tracking Risk for Substance Use Disorder

量化和跟踪药物使用障碍的风险

基本信息

批准号：
8038395
负责人：
LEVENT KIRISCI
金额：
$ 13.54万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-03-01 至 2015-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8038395
关键词：
12 year old 19 year old Accounting Adult African American Age Alcohols American Area Award Basic Science Categories Childhood Complement Computers Confidentiality Consumption Data Data Set Derivation procedure Development Diagnosis Dimensions Dose Early Diagnosis Empirical Research Enrollment Ensure Epidemiology Ethnic Origin Ethnic group Etiology European Family Family Study Female Foundations Funding Future Gender Genetic Goals Health Heritability Illicit Drugs Independent Scientist Award Individual Intervention Knowledge Measurement Measures Methodology Methods Metric Minnesota Modeling National Institute of Drug Abuse Paper Persons Pharmaceutical Preparations Pilot Projects Population Procedures Property Protocols documentation Psychometrics Research Research Personnel Risk Sampling Scoring Method Screening procedure Socioeconomic Status Staging Standardization Substance Use Disorder Surveys System Testing Time Translational Research Twin Multiple Birth Validation Validity and Reliability Variant Work Youth addiction base boys career development cohort design disorder risk drug abuse education genetic epidemiology genetics of alcoholism girls heuristics high risk indexing instrument male non-drug novel practical application programs prototype response skills sound statistics theories tool trait user-friendly validation studies young adult

项目摘要

DESCRIPTION (provided by applicant): The overarching aim of this competitive renewal (K02) application is to advance my knowledge in genetics and epidemiology, and to acquire specialized skills in quantitative methodology in tandem with completing the research initiated in the first funding cycle pertaining to development and validation of a measure of substance use disorder (SUD) liability. This research has yielded a provisional liability index (LI) for quantifying SUD risk in boys at ages 10-12, 12-14, 16 and 19 and girls at ages 10-12. The LI has been shown to predict SUD between childhood and young adulthood, indicating that it may be practical for detecting high risk youths. Moreover, variation on the LI has been shown to have 79% heritability in a pilot study, indicating that it may also be a heuristic tool in SUD etiology research. Employing item response theory (IRT) methodology, in conjunction with longitudinal multivariate modeling, the provisional LI will be completed up to age 30 in males and up to age 28 in females using the data accrued by the NIDA-funded Center for Education and Drug Abuse Research (CEDAR) where I am Co-PI and Director of the Methodology and Statistics Core. During the next 5 years, the LI will additionally be cross-validated on three large datasets having appropriate item content: 1) the Collaborative Studies on the Genetics of Alcoholism (COGA), 2) the Minnesota Twin Family Study (MTFS), and, 3) the National Epidemiological Survey on Alcohol and Related Conditions. (NESARC). Following the cross-validation studies, the LI will be prepared for computer adaptive test (CAT) administration to complement the paper and pencil version. Conclusion of this task sets the stage for future R01 funding at which time I will conduct a standardization study to derive norms for the final LI versions between childhood and adulthood and to elucidate genetic mechanisms. PUBLIC HEALTH RELEVANCE: Commensurate with the perspective of basic science informing practical application, this project will derive and validate an instrument - the liability index - to quantify SUD risk on a continuous scale ranging from 0-1 based on CEDAR's 19 years of empirical research into SUD etiology. Practical instruments will be developed for use across the main chronological period for detecting youths and young adults who are at high risk for use.

描述（由申请人提供）：此竞争性更新（K02）申请的总体目标是提高我在遗传学和流行病学方面的知识，并获得定量方法方面的专业技能，同时完成第一个资助周期中启动的与以下相关的研究制定并验证物质使用障碍（SUD）责任的衡量标准。这项研究得出了一个临时责任指数 (LI)，用于量化 10-12 岁、12-14 岁、16 岁和 19 岁男孩以及 10-12 岁女孩的 SUD 风险。 LI 已被证明可以预测儿童期和青年期之间的 SUD，这表明它对于检测高危青少年可能是实用的。此外，一项试点研究表明，LI 的变异具有 79% 的遗传力，这表明它也可能是 SUD 病因学研究中的启发式工具。采用项目反应理论 (IRT) 方法，结合纵向多变量模型，使用 NIDA 资助的教育和药物滥用中心积累的数据，将完成男性 30 岁以下和女性 28 岁以下的临时 LI研究（CEDAR），我是方法论和统计核心的联合首席研究员和主任。在接下来的 5 年内，LI 还将在具有适当项目内容的三个大型数据集上进行交叉验证：1) 酒精中毒遗传学合作研究 (COGA)，2) 明尼苏达双胞胎家庭研究 (MTFS)，以及， 3) 全国酒精及相关状况流行病学调查。（NESARC）。在交叉验证研究之后，LI 将为计算机自适应测试 (CAT) 管理做好准备，以补充纸笔版本。这项任务的结论为未来的 R01 资助奠定了基础，届时我将进行标准化研究，以得出儿童期和成年期最终 LI 版本的规范，并阐明遗传机制。公共卫生相关性：与基础科学指导实际应用的角度相一致，该项目将基于 CEDAR 19 年的实证研究，推导并验证一种工具——责任指数——以 0-1 的连续范围量化 SUD 风险。 SUD 病因学。将开发实用工具以在主要时间段内使用，以检测高风险的青少年和年轻人。