METHODOLOGY AND STATISTICS CORE

方法论和统计核心

• 批准号: 7618713
• 负责人: LEVENT KIRISCI
• 金额: $ 14.42万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7618713
• 关键词: Alcohols; Categories; Cohort Effect; Consumption; Data; Derivation procedure; Development; Diagnostic; Diagnostic and Statistical Manual; Ensure; Etiology; Methodology; Mission; Outcome; Pharmaceutical Preparations; Protocols documentation; Psychometrics; Relative (related person); Research; Substance Use Disorder; Testing; Tobacco; Validity of Results; biobehavior; biopsychosocial; disorder risk; heuristics; indexing; instrument; proband; statistics; theories; trait

The Methodology and Statistics Core performs six main tasks essential to achieving the Center's mission. The tasks are: 1) Conduct psychometric analyses of all instruments used in CEDAR to ensure their quality; 2) Evaluate potential threats to the validity of results that could be caused by bias associated with proband ascertainment strategy, cohort effects, protocol implementation, and attrition; 3) Spearhead the development and psychometric analyses of the biobehavioral and environmental constructs contributing to derivation of the substance use disorder (SUD) liability index; 4) Conduct the statistical analyses to test CEDAR's biopsychosocial theory of SUD etiology; 5) Elucidate the relative contribution of the different facets of alcohol, tobacco, other drugs consumption topology in SUD risk and outcome; and, 6) Determine the validity and heuristic utility of quantifying the various DSM diagnostic categories of SUD. These interrelated tasks, requiring extensive synergy among the Center's cores and research modules, constitute essential operational requirements for satisfying CEDAR's mission.

方法和统计核心执行六项对于实现中心的目标至关重要的主要任务 使命。任务是： 1）对CEDAR使用的所有仪器进行心理测量分析，以确保其质量； 2) 评估对结果有效性的潜在威胁，这些威胁可能是由与先证者确定策略、队列效应、方案实施和人员流失相关的偏差引起的； 3) 带头进行生物行为和环境结构的开发和心理测量分析，有助于推导物质使用障碍（SUD）责任指数； 4) 进行统计分析以检验CEDAR的SUD病因学生物心理社会理论； 5) 阐明酒精、烟草和其他药物消费拓扑的不同方面对 SUD 风险和结果的相对贡献； 6) 确定量化 SUD 的各种 DSM 诊断类别的有效性和启发式效用。这些相互关联的任务需要中心核心和研究模块之间的广泛协同，构成了满足 CEDAR 使命的基本业务要求。