Integrative Approach to Functional Neuroimaging of ADHD

ADHD 功能神经影像的综合方法

• 批准号: 7122402
• 负责人: KURT P. SCHULZ
• 金额: $ 15.5万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7122402
• 关键词: adolescence (12-20); attention deficit disorder; behavioral /social science research tag; bioimaging /biomedical imaging; clinical research; cognition; functional magnetic resonance imaging; human subject; interdisciplinary collaboration; mental disorder chemotherapy; methylphenidate; neuroimaging; neuropsychological tests; neuropsychology; patient oriented research; psychopharmacology; sign /symptom; statistics /biometry

DESCRIPTION (provided by applicant): The primary goal of this proposal is to provide the applicant with expertise in the basic physical and computer sciences, neuroimaging methodology, and developmental psychopathology necessary to conduct cutting-edge research using functional magnetic resonance imaging (fMRI) based techniques so that he can develop an independent research career. Specifically, the proposal will initially provide an opportunity to train with and work under the supervision of a multidisciplinary team of consultants on two projects related to ADHD that will use fMRI to study: I) atomoxetine and methylphenidate treatment effects on frontostriatal activation in children with ADHD; and II) brain activation gradients related to persistence of ADHD in adolescence. The multidisciplinary team of consultants will ensure training in the wide variety disciplines that are incorporated in functional neuroimaging research. The various projects that form the research component of this proposal will also provide the applicant with the opportunity to work with other pre-eminent researchers who are consultants on these projects. The training and data generated by the research component of this proposal will inform and hopefully generate the pilot data of future research projects by the applicant that will eventually lead to an independent research career. The development of an independent research career that integrates approaches from developmental psychopathology, basic and behavioral neurosciences, and neuroimaging in the study of ADHD and other developmental disorders is the expected outcome of this award.

描述（由申请人提供）：该提案的主要目标是为申请人提供基础物理和计算机科学、神经影像方法和发育精神病理学方面的专业知识，以使用基于功能磁共振成像（fMRI）的技术进行前沿研究。技术使他能够发展独立的研究生涯。具体来说，该提案最初将提供一个机会，在与 ADHD 相关的两个项目的多学科顾问团队的监督下进行培训和工作，这两个项目将使用功能磁共振成像来研究：I) 托莫西汀和哌醋甲酯治疗对 ADHD 儿童额纹状体激活的影响; II）与青春期 ADHD 持续存在相关的大脑激活梯度。多学科顾问团队将确保在功能神经影像研究中纳入各种学科的培训。构成本提案研究部分的各种项目还将为申请人提供与担任这些项目顾问的其他杰出研究人员合作的机会。该提案的研究部分生成的培训和数据将为申请人提供信息并有望生成未来研究项目的试点数据，最终将导致独立的研究生涯。该奖项的预期成果是发展独立的研究事业，将发展精神病理学、基础和行为神经科学以及神经影像学的方法整合到多动症和其他发育障碍的研究中。