NW Research Center for Excellence in Biodefense and Emerging Infectious Diseases

西北生物防御和新发传染病卓越研究中心

• 批准号: 7907149
• 负责人: Samuel I Miller
• 金额: $ 195.49万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-12 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7907149
• 关键词: NW; Research; Center; Excellence; Biodefense

DESCRIPTION (provided by applicant): The Region X Northwest Regional Center of Excellence (NWRCE) for Biodefense and Emerging Infectious Diseases is an essential component in a nationwide network of biomedical research programs to combat infectious disease threats to the population. The NWRCE is currently a highly interactive and thematic program focused on Gram-negative bacterial pathogens, and the same general consistent focus has existed since its inception. There are three research themes: (1) mechanisms of Gram-negative bacterial pathogenesis, (2) innate immune responses to Gram-negative bacterial pathogens, and (3) translation of (1) and (2) into early stage therapeutic development to prevent or treat Gram-negative bacterial diseases. The NWRCE is centered at the University of Washington (UW) in Seattle; in this renewal application, multiple sites are proposed in Seattle, two in Oregon, one in Idaho, and one in Maryland. Additional sites for collaboration include the NIAID Rocky Mountain Laboratory in Montana, the University of Victoria, British Columbia, and collaborators at sites in Thailand, Sweden, and Mexico. The projects, cores, domestic and international sites, as well as collaborators, are highly interactive. The individuals that make up this proposal have worked together for many years during the last funding period and before the NWRCE was created. The majority of investigators newly added to this to this application for renewed funding of the NWRCE have had long collaborative relationships with members of the center. The interactive nature and focus of the NWRCE is a major strength of the program and allows the NWRCE to rapidly and nimbly respond to national priorities to achieve important objectives with respect to Gram-negative bacterial infections. RELEVANCE: The Northwest Regional Center of Excellence for Biodefense and Emerging Infectious Diseases (NWRCE) is a large infectious disease research program composed of many investigators in the Pacific Northwest and beyond. The center conducts research to understand bacterial disease and produce countermeasures against these infections which are deemed of national importance. STRATEGIC MANAGEMENT PLAN DESCRIPTION: The development and management of the NWRCE has been achieved through the combined efforts of the key administrative staff (Director, Associate Director, Assistant Director, Laboratory Manager, and Award Director) as well as the positions and personnel which have been added during the course of the award. The coordination of NWRCE activities and the management of the central select agent lab is accomplished by this group, providing a clearinghouse for information as well as a conduit for communication among the dispersed elements of the RCE. Specifically, the Administrative Core organizes and manages the resources of the NWRCE, organizes meetings and otherwise facilitates communication between all components of the NWRCE, prepares reports and measures outcomes, ensures compliance with regulations regarding biosafety and security of materials, data, and facilities, identifies opportunities for new and translational activities of the NWRCE while addressing weaknesses in the execution of the NWRCE strategic plan, recruits individuals and administers developmental and career development projects through the Award Program, maintains compliance with intellectual property requirements, maintains compliance with the Patriot Act, and establishes an interface with the local, regional, and national public health network so that NWRCE capability can be utilized in a national or regional public health emergency.

描述（由申请人提供）：X区西北区域卓越中心（NWRCE）针对生物化和新兴的传染病是全国生物医学研究计划网络中的重要组成部分，以消除对人群感染性疾病威胁的威胁。 NWRCE目前是一项高度交互式和主题计划，专注于革兰氏阴性细菌病原体，自成立以来，已经存在相同的一般一致焦点。有三个研究主题：（1）革兰氏阴性细菌发病机理的机制，（2）对革兰氏阴性细菌病原体的先天免疫反应，以及（3）（3）（3）将（1）和（2）转化为早期治疗性发育，以预防或治疗革兰氏阴性细菌疾病。 NWRCE以西雅图华盛顿大学（UW）为中心；在此续签应用中，在西雅图提出了多个地点，在俄勒冈州有两个，一个在爱达荷州，一个在马里兰州。其他合作的地点包括蒙大拿州的Niaid Rocky山地实验室，维多利亚大学，不列颠哥伦比亚省，泰国，瑞典和墨西哥的遗址。项目，核心，国内和国际网站以及合作者都具有高度互动性。构成该提案的个人在最后一个资金期和NWRCE创建之前已经合作了很多年。大多数调查人员新将其添加到本申请中，以重新获得NWRCE的资金，与中心成员长期以来一直在合作。 NWRCE的互动性质和重点是该计划的主要优势，并允许NWRCE快速而细微地响应国家优先事项，以实现有关革兰氏阴性细菌感染的重要目标。 相关性：西北地区卓越的生物化和新兴传染病（NWRCE）是一项大型传染病研究计划，由太平洋西北及其他地区的许多研究者组成。该中心进行研究以了解细菌疾病，并针对认为具有国家重要性的这些感染产生对策。 战略管理计划描述： NWRCE的发展和管理是通过主要行政人员（董事，副主任，助理主任，实验室经理和奖励主任）以及在奖励期间添加的职位和人员的共同努力来实现的。 NWRCE活动的协调和中央选择代理实验室的管理是由该小组完成的，为信息提供了一个交换所以及RCE分散元素之间通信的渠道。 Specifically, the Administrative Core organizes and manages the resources of the NWRCE, organizes meetings and otherwise facilitates communication between all components of the NWRCE, prepares reports and measures outcomes, ensures compliance with regulations regarding biosafety and security of materials, data, and facilities, identifies opportunities for new and translational activities of the NWRCE while addressing weaknesses in the execution of the NWRCE strategic plan, recruits individuals and administers developmental通过奖励计划，维持符合知识产权要求，维持“爱国者法”的符合性，并与当地，地区和国家公共卫生网络建立界面，以便在国家或地区公共卫生紧急情况下使用NWRCE能力，并建立了与职业发展项目。