BIOINFORMATICS AND BIOSTATISTICS CORE FACILITY

生物信息学和生物统计学核心设施

• 批准号: 7960378
• 负责人: JAMES HARNER
• 金额: $ 13.34万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7960378
• 关键词: Bioinformatics; Biometry; Biostatistics Core; Cancer Biology; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Computers; Core Facility; DNA Microarray Chip; Data; Data Set; Emerging Technologies; Experimental Designs; Faculty; Funding; Genetic; Goals; Grant; Institution; Malignant Neoplasms; Mass Spectrum Analysis; Modeling; Proteomics; Research; Research Personnel; Research Project Grants; Resources; Scientist; Seeds; Signal Transduction; Software Engineering; Source; Specialist; Statistical Data Interpretation; Structure; Techniques; Training; United States National Institutes of Health; Vision; Work; base; computer based statistical methods; forest; markov model; member; network models; novel strategies; programs; statistics

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The analysis of datasets requires statistics in order to validate the findings. The department of statistics supports HSC and MBRCC research efforts through collaborations with HSC scientists providing faculty for statistical analysis of data and input to experimental design and interpretation. The emerging technologies of DNA microarray and Proteomics require advanced biostatistical applications, such as Hidden Markov Modeling and Random Forest techniques, respectively. Faculty members in the Department of Statistics have these expertise, as well. Thus, we set up a dedicated facility in the WVU HSC whereby faculty members from Statistics work in the HSC and provide support for our research program. Additionally, the fields of cancer biology, proteomics and genetics, require bioinformatics support. To this end, the MBRCC and Cobre program hired Lan Guo, a computer scienctist and bioinformatics specialist with advanced training in computer software development. Dr. Guo's developed a novel approach to bioinformatics based on the Dempsey-Shaffer model, which is superior to the currently employed Bayesian Networks model. In turn, the Statistics department has hired a bioinformatics specialist who specializes in analysis of mass spectrometry data. It is our long term goal to establish a Bioinformatics and Biostatistics Program at WVU and this core facility and our new faculty hires will seed this endeavor. In this proposal, we discuss the structure of this core facility, priority use and billing mechanisms, support for faculty research projects, research initiatives, as well as our long term vision of establishing an active bioinformatics program at WVU HSC.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 数据集的分析需要统计数据才能验证发现。 统计局通过与HSC科学家的合作来支持HSC和MBRCC研究工作，从而为数据和实验设计和解释的投入提供了统计分析。 DNA微阵列和蛋白质组学的新兴技术分别需要先进的生物统计应用，例如隐藏的马尔可夫建模和随机森林技术。 统计系的教职员工也具有这些专业知识。 因此，我们在WVU HSC建立了一个专门的设施，该设施在HSC中的统计数据中工作，并为我们的研究计划提供支持。 此外，癌症生物学，蛋白质组学和遗传学领域需要生物信息学支持。 为此，MBRCC和COBRE计划雇用了计算机精心及其生物信息学专家Lan Guo，通过计算机软件开发方面的高级培训。 Guo博士基于Dempsey-Shaffer模型开发了一种新颖的生物信息学方法，该模型优于当前使用的贝叶斯网络模型。 反过来，统计局聘请了一位专门研究质谱数据分析的生物信息学专家。 我们的长期目标是在WVU建立生物信息学和生物统计学计划，该核心设施以及我们的新教师雇用将使这一努力播种。 在此提案中，我们讨论了该核心设施，优先使用和计费机制的结构，对教师研究项目的支持，研究计划以及我们在WVU HSC建立活跃的生物信息学计划的长期愿景。