Administrative and Biostatistics Core

行政和生物统计核心

• 批准号: 10629066
• 负责人: TONY R. HUNTER
• 金额: $ 22.79万
• 依托单位: SALK INSTITUTE FOR BIOLOGICAL STUDIES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-06 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10629066
• 关键词: Adopted; Bioinformatics; Biometry; Biostatistics Core; Cancer Etiology; Cessation of life; Collaborations; Communication; Communities; Data; Data Analyses; Data Analytics; Data Set; Data Storage and Retrieval; Decision Making; Deposition; Disparate; Ensure; Epigenetic Process; Exhibits; Experimental Designs; Faculty; Foundations; Future; Goals; Heterogeneity; Information Technology; Lead; Leadership; Malignant Neoplasms; Malignant neoplasm of pancreas; Metabolic; Methods; Monitor; Pancreatic Ductal Adenocarcinoma; Patients; Reagent; Recommendation; Reporting; Reproducibility; Research; Research Project Grants; Resource Sharing; Resources; Risk; Services; Signal Pathway; System; Work; cost effective; data exchange; data integration; data sharing; experimental study; meetings; member; new therapeutic target; novel; organizational structure; programs; public repository; response; success; therapy resistant; tumor; Adopted; Bioinformatics; Biometry; Biostatistics Core; Cancer Etiology; Cessation of life; Collaborations; Communication; Communities; Data; Data Analyses; Data Analytics; Data Set; Data Storage and Retrieval; Decision Making; Deposition; Disparate; Ensure; Epigenetic Process; Exhibits; Experimental Designs; Faculty; Foundations; Future; Goals; Heterogeneity; Information Technology; Lead; Leadership; Malignant Neoplasms; Malignant neoplasm of pancreas; Metabolic; Methods; Monitor; Pancreatic Ductal Adenocarcinoma; Patients; Reagent; Recommendation; Reporting; Reproducibility; Research; Research Project Grants; Resource Sharing; Resources; Risk; Services; Signal Pathway; System; Work; cost effective; data exchange; data integration; data sharing; experimental study; meetings; member; new therapeutic target; novel; organizational structure; programs; public repository; response; success; therapy resistant; tumor

PROJECT SUMMARY – Administrative and Biostatistics Core The overall goal of the Administrative and Biostatistics Core (Admin Core) is to facilitate research efforts toward understanding intrinsic resistance to therapy in pancreatic ductal adenocarcinoma (PDA). This will be accomplished by providing the three Research Projects (Projects) and the three Shared Resource Cores (Cores) with organizational support, professional project management, biostatistical expertise, data storage and sharing solutions, and a governance framework. The Admin Core will plan and coordinate meetings between the scientific teams, as well as between the scientific teams and the leadership groups. The Admin Core will include a Project Manager, who will provide professional project management services to ensure that stated objectives are successfully achieved. As part of this effort, the Project Manager will monitor Core activities to ensure that efforts of these cutting-edge scientific resources are integrated and coordinated, and that the Cores are operating effectively and efficiently to meet the needs of the Projects. The Project Manager will also establish a governance framework for resolving potential conflicts between team members and for managing resource utilization and budgetary concerns. The Admin Core will include a Biostatistics Unit that will be intimately involved in all experimental design and data analysis. The Biostatistics Unit will be responsible for ensuring that all experiments are sufficiently powered, and that the resulting data are analyzed using the most scientifically rigorous approaches. Novel methods will be developed when needed. One faculty-level statistician will split their effort between the Biostatics Unit and the bioinformatics team within the Tumor and Microenvironment Heterogeneity Core, coordinating communication and the transfer of data between these data analytic groups. Finally, the Admin Core will include a Data Curator who will help establish and oversee a centralized data-storage system into which all data generated by the scientific teams will be deposited and properly annotated. This resource will facilitate the integration of disparate datasets, as well as the exchange of data and reagents between the Projects, the Cores, and the external research community, as appropriate. Thus, the specific aims of the Admin Core are to: 1) provide overall organizational support including the coordination of meetings between the Projects, the Cores, and the leadership committees, 2) provide project management services to ensure that scientific objectives are achieved in an efficient and cost-effective manner, 3) provide biostatistical expertise to ensure experimental rigor and reproducibility, and 4) create and manage a centralized data storage and sharing system to enable data integration.

项目摘要 - 行政和生物统计学核心 行政和生物统计学核心（管理员核心）的总体目标是促进研究工作 了解胰腺导管腺癌（PDA）中对治疗的内在耐药性。这将是 通过提供三个研究项目（项目）和三个共享资源核心（核心）来完成 借助组织支持，专业项目管理，生物统计学专业知识，数据存储和共享 解决方案和治理框架。管理员核心将计划和协调 科学团队以及科学团队与领导小组之间。管理员核心将包括 项目经理将提供专业的项目管理服务，以确保既定目标 成功实现了。作为这项工作的一部分，项目经理将监视核心活动，以确保 这些尖端的科学资源的努力是整合和协调的，并且核心正在运作 有效，有效地满足项目的需求。项目经理还将建立治理 解决团队成员与管理资源利用和管理潜在冲突的框架 预算问题。管理员核心将包括一个生物统计学单元，该单元将密切参与所有 实验设计和数据分析。生物统计学单元将负责确保所有实验 具有足够的动力，并使用最科学严格的数据分析所得数据 方法。需要在需要时开发新方法。一位教师级统计学家将分裂他们的努力 在肿瘤和微环境中的生物统计单元与生物信息学团队之间 异质性核心，协调通信和这些数据分析组之间的数据传输。 最后，管理员核心将包括一个数据策展人，该数据策展人将帮助建立和监督集中式数据存储 科学团队生成的所有数据都将被存入并正确注释的系统。这 资源将促进不同数据集的集成，以及数据和试剂的交换 在项目，核心和外部研究社区之间。那，具体目的 管理员的核心是：1）提供整体组织支持，包括会议协调 在项目，核心和领导委员会之间，2）为项目管理服务提供 确保以有效且具有成本效益的方式实现科学目标，3）提供生物统计学 确保实验性严格和可重复性的专业知识，以及4）创建和管理集中式数据存储 和共享系统以启用数据集成。