Pooling of Prospective Studies of Diet and Cancer

饮食与癌症前瞻性研究的汇集

基本信息

批准号：
7191215
负责人：
STEPHANIE A SMITH-WARNER
金额：
$ 36.8万
依托单位：
HARVARD SCHOOL OF PUBLIC HEALTH
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-12-01 至 2011-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7191215
关键词：
Age Alcohol consumption Alcohols All-Trans-Retinol Animals Ascorbic Acid Asia Attenuated Australia Body mass index Calcium Calcium Milk Carotenoids Clinical Cohort Studies Communication Consumption Country Data Diet Dietary Assessment Dietary Factors Elderly Estrogen Receptor Status Estrogen receptor negative Ethnic Origin Europe Fatty Acids Fatty acid glycerol esters Female Fishes Folate Follow-Up Studies Food Gleason Grade for Prostate Cancer Glioma Habits Heterogeneity Incidence Individual Intake Malignant Neoplasms Malignant neoplasm of prostate Marines Meat Meta-Analysis Methods Modeling Multivitamin North America Numbers Omega-3 Fatty Acids Outcome Participant Population Process Prospective Studies Publication Bias Publications Publishing Range Rate Research Design Research Personnel Risk Risk Factors Series Smoker Smoking Smoking Status Source Staging Tomatoes Vegetables Vitamin A Vitamin D Vitamin E Woman cancer risk cancer site cohort cost diet and cancer follow-up fruits and vegetables inclusion criteria insight male malignant breast neoplasm men older men prospective sex

项目摘要

We propose to examine the association between dietary factors and risk of advanced prostate cancer, estrogen receptor negative breast cancer, and gliomas in the Pooling Project of Prospective Studies of Diet and Cancer (Pooling Project), a consortium of 27 prospective cohort studies. Each study met the following inclusion criteria: used a prospective study design, assessed usual diet using a validated dietary assessment method, and met the minimum number of incident cases. The studies were conducted in North America (n=18), Europe (n=6), Asia (n=2), and Australia (n=1) with 834,339 male (n=14 studies) and 1,364,231 female (n=23 studies) participants. During follow-up of these studies, 5,503 advanced prostate cancer (which will be analyzed separately as either stage C and D or as Gleason score >7), 5,484 estrogen receptor negative breast cancer, and 2,516 glioma cases were identified. For advanced prostate cancer, associations with dairy foods, calcium, vitamin D, meat, fat, fruits, vegetables, vitamin E, and body mass index will be examined. For estrogen receptor negative breast cancer, analyses will evaluate fruits, vegetables, and alcohol. For gliomas, associations with vitamins D, C, and E, processed meat, fish, fat, fruits, vegetables, and alcohol will be analyzed. Expansion of the Pooling Project to these cancers with intermediate or low incidence rates will take advantage of the statistical power of this project. In addition, because individual studies will not be required to have published on the specific associations being examined, publication bias will be avoided in these analyses. We will recode the primary data from each study using a standardized approach across studies so that the exposures, covariates, and outcomes will be defined and modeled consistently across studies. This standardized approach will reduce potential sources of between-studies heterogeneity. Analyses will also evaluate whether associationsare modified by other risk factors including sex, ethnicity, age, smoking habits, and other dietary factors to identify potential high-risk groups that may not otherwise be identified in smaller studies. Because the Pooling Project includes populations with different diets, the range of intakes that can be examined will be wider than in individual studies, further increasing the statistical power of the study. The annual meetings, and frequent communication among investigators, will facilitate the analyses and interpretation of the findings. These analyses will take full advantage of extensive data already collected to provide powerful insights into the relation between diet and the risk of advanced prostate cancer, estrogen receptor negative breast cancer, and gliomas, cancer sites that have been examined in few prospective studies. This project provides a highly cost-effective approach to evaluate these pressing issues in a detailed, standardized manner, to yield robust findings that have immediate clinical and public relevance.

我们建议检查饮食因素与晚期前列腺癌风险之间的关联，饮食前瞻性研究汇集项目中的雌激素受体阴性乳腺癌和神经胶质瘤癌症（汇集项目），一个由 27 项前瞻性队列研究组成的联盟。每项研究均满足以下条件纳入标准：采用前瞻性研究设计，使用经过验证的饮食评估来评估日常饮食方法，并满足最少事件案例数。研究在北美进行 (n=18)、欧洲 (n=6)、亚洲 (n=2) 和澳大利亚 (n=1)，其中男性 834,339 名（n=14 研究）和 1,364,231 名女性（n=23 研究）参与者。在这些研究的随访期间，5,503 例晚期前列腺癌（其中将分别作为 C 期和 D 期或格里森评分 >7）进行分析，5,484 雌激素受体乳腺癌阴性，并确定了 2,516 例神经胶质瘤病例。对于晚期前列腺癌，协会乳制品、钙、维生素 D、肉类、脂肪、水果、蔬菜、维生素 E 和体重指数检查了。对于雌激素受体阴性乳腺癌，分析将评估水果、蔬菜和酒精。对于神经胶质瘤，与维生素 D、C 和 E、加工肉、鱼、脂肪、水果、蔬菜、并对酒精进行分析。将汇集项目扩展到这些中度或低度癌症发病率将利用该项目的统计能力。另外，由于个人不需要发表关于正在审查的特定协会的研究，发表偏倚在这些分析中将被避免。我们将使用标准化的方法重新编码每项研究的主要数据跨研究的方法，以便定义和建模暴露、协变量和结果跨研究的一致性。这种标准化方法将减少研究间的潜在来源异质性。分析还将评估关联是否会受到其他风险因素的影响，包括性别、种族、年龄、吸烟习惯和其他饮食因素，以确定潜在的高危人群在较小的研究中不会被识别。因为汇集项目包括以下人群：不同的饮食，可以检查的摄入量范围将比个别研究更广泛，进一步提高研究的统计功效。年会频繁，沟通频繁调查人员将有助于对调查结果进行分析和解释。这些分析将充分利用已收集的大量数据来提供有关饮食与饮食之间关系的有力见解晚期前列腺癌、雌激素受体阴性乳腺癌、神经胶质瘤、癌症部位的风险很少有前瞻性研究对此进行了检验。该项目提供了一种极具成本效益的方法以详细、标准化的方式评估这些紧迫问题，得出可靠的结论直接的临床和公众相关性。