Circulating Vitamin D Levels and Risk of Breast and Colorectal Cancer: a Pooled A

循环维生素 D 水平与乳腺癌和结直肠癌的风险：汇总 A

• 批准号: 8523027
• 负责人: STEPHANIE A SMITH-WARNER
• 金额: $ 4.67万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8523027
• 关键词: 25-hydroxyvitamin D; Asia; Biochemical; Biological Markers; Blood specimen; Cancer Burden; Characteristics; Cohort Studies; Collaborations; Colorectal Cancer; Confounding Factors (Epidemiology); Data; Databases; Diet; Dose; Epidemiology; Estrogen Receptors; Estrogen receptor positive; Etiology; Europe; Future; Genetic Polymorphism; Genetic Variation; Health; Health Status; Heterogeneity; Incidence; Individual; Insulin-Like Growth Factor I; Intake; Literature; Malignant Neoplasms; Measurement; Measures; Meta-Analysis; Modeling; North America; Personal Communication; Population; Positioning Attribute; Principal Investigator; Progesterone Receptors; Prospective Studies; Publication Bias; Publications; Publishing; Recommendation; Rectal Cancer; Reporting; Research Design; Research Personnel; Risk; Risk Factors; Skin Cancer; Source; Subgroup; Sun Exposure; Tumor Subtype; United States; Vitamin D; Vitamin D3 Receptor; Woman; base; calcium intake; cancer risk; cancer site; cohort; design; diet and cancer; experience; inclusion criteria; insight; lifestyle factors; malignant breast neoplasm; melanoma; men; older women; programs; prospective; public health relevance; randomized trial; response; tumor

DESCRIPTION (provided by applicant): We propose to conduct a prospective, pooled analysis of the association between circulating 25- hydroxyvitamin D [25(OH)D] levels and risk of breast and colorectal cancer within a consortium of 15 cohort studies. We hypothesize that higher levels of circulating 25(OH)D levels are associated with a reduced risk of colorectal and breast cancer. These associations are hypothesized to be stronger among leaner individuals, among more physically active individuals, and among individuals with higher calcium intakes. Inclusion criteria for participation in the consortium are that a study used a prospective study design, collected blood samples prospectively, and had at least 50 cases of the specific cancer being analyzed. The 15 studies in the consortium were conducted in North America (n=10), Europe (n=4), and Asia (n=1) and include 5061 colorectal cancer cases and 6817 breast cancer cases whose circulating 25(OH)D levels have been measured previously or will be measured (mostly as part of this proposal). We will analyze the primary data from each study so that circulating 25(OH)D levels and confounding variables will be modeled consistently across studies. This will reduce potential sources of between-studies heterogeneity due to different analytic approaches as encountered in the published literature, as well as allow for examination of different categorizations of circulating 25(OH)D levels. We also will be able to evaluate whether associations vary among population subgroups, by other biochemical risk factors, and by tumor subtypes which cannot be evaluated fully in a meta-analysis of the published literature. Further, new data will be generated in seven of the studies which will reduce the influence of publication bias. This proposal takes full advantage of extensive data collected throughout the world, builds upon the expertise and established collaboration of the investigators, and takes advantage of the statistical power of the project. These analyses will provide powerful insights into the relation between vitamin D and breast and colorectal cancer risk. The results have the potential to inform recommendations regarding sun exposure and vitamin D intake requirements, and contribute to the reduction of the burden of cancer. PUBLIC HEALTH RELEVANCE: Confirming whether vitamin D reduces the risk of breast and colorectal cancer, two of the most common cancers in the United States, is critical because current health recommendations typically do not encourage intakes of vitamin D high enough to appreciably influence 25(OH)D levels and they tend to discourage sun exposure because of the risk of skin cancer and melanoma.

描述（由申请人提供）：我们建议在 15 项队列研究的联合体中，对循环 25-羟基维生素 D [25(OH)D] 水平与乳腺癌和结直肠癌风险之间的关联进行前瞻性汇总分析。我们假设循环 25(OH)D 水平较高与结直肠癌和乳腺癌风险降低相关。据推测，这些关联在较瘦的个体、较活跃的个体以及钙摄入量较高的个体中更为明显。参与该联盟的纳入标准是，一项研究采用了前瞻性研究设计，前瞻性地采集了血液样本，并且对至少 50 例特定癌症进行了分析。该联盟的 15 项研究在北美 (n=10)、欧洲 (n=4) 和亚洲 (n=1) 进行，包括 5061 例结直肠癌病例和 6817 例乳腺癌病例，其循环 25(OH)D 水平之前已经测量过或将要测量（主要作为本提案的一部分）。我们将分析每项研究的主要数据，以便在各个研究中对循环 25(OH)D 水平和混杂变量进行一致的建模。这将减少由于已发表文献中遇到的不同分析方法而导致研究间异质性的潜在来源，并允许检查循环 25(OH)D 水平的不同分类。我们还能够评估人群亚组之间的关联是否因其他生化危险因素以及肿瘤亚型而异，而这些关联在已发表文献的荟萃分析中无法完全评估。此外，其中七项研究将产生新数据，这将减少发表偏倚的影响。该提案充分利用了在世界各地收集的广泛数据，以研究人员的专业知识和既定合作为基础，并利用了该项目的统计能力。这些分析将为维生素 D 与乳腺癌和结直肠癌风险之间的关系提供有力的见解。研究结果有可能为有关阳光照射和维生素 D 摄入量的建议提供信息，并有助于减轻癌症负担。 公共健康相关性：确认维生素 D 是否可以降低乳腺癌和结直肠癌（美国最常见的两种癌症）的风险至关重要，因为当前的健康建议通常不鼓励维生素 D 的摄入量足够高以明显影响 25(OH) )D 水平，并且由于存在患皮肤癌和黑色素瘤的风险，它们往往会阻止阳光照射。

项目成果

Serum 25-hydroxyvitamin D, vitamin D binding protein and risk of colorectal cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial.

前列腺癌、肺癌、结直肠癌和卵巢癌筛查试验中血清 25-羟基维生素 D、维生素 D 结合蛋白和结直肠癌风险。

• 发表时间: 2015-03-15
• 影响因子: 6.4
• 作者: Weinstein, Stephanie J;Purdue, Mark P;Smith;Mondul, Alison M;Black, Amanda;Ahn, Jiyoung;Huang, Wen;Horst, Ronald L;Kopp, William;Rager, Helen;Ziegler, Regina G;Albanes, Demetrius
• 通讯作者: Albanes, Demetrius