POOLED ANALYSIS OF PROSPECTIVE ONCOLOGY ACADEMIC AWARD

前瞻性肿瘤学学术奖的汇总分析

• 批准号: 6522439
• 负责人: STEPHANIE A SMITH-WARNER
• 金额: $ 7.25万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-07 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6522439
• 关键词: behavioral /social science research tag; breast neoplasms; clinical research; disease /disorder etiology; human subject; lung neoplasms; neoplasm /cancer epidemiology; nutrition related neoplasm /cancer; nutrition related tag; smoking; tobacco abuse

DESCRIPTION: (Applicant's Description) Candidate: Stephanie Smith-Warner received her doctoral degree in epidemiology, with a focus on nutritional epidemiology, from the University of Minnesota. She has been involved with the conduct of several types of epidemiologic studies and has experience in the areas of study design, questionnaire development, data management and data analysis. Dr. Smith-Warner is interested in strengthening her research background and development as an independent researcher in the fields of cancer epidemiology and nutritional epidemiology. Environment: Dr. David J. Hunter, the current Project Leader of the Pooling Project, has agreed to be the sponsor for this proposal. Dr. Hunter has extensive experience in mentoring graduate students and postdoctoral fellows in diverse areas of study. In addition, the Principal Investigators of the individual studies included in the Pooling Project are enthusiastic about expanding their collaboration to evaluate diet and lung cancer associations. Finally, faculty in the Nutrition Department at the Harvard School of Public Health actively collaborate with scientists in other departments and institutions. This multifaceted, collaborative environment provides unique opportunities for furthering Dr. Smith-Warner's research training. Research Proposal: This proposal builds upon the existing Pooling Project of Prospective Studies and Cancer to evaluate associations between diet and lung cancer, a leading cause of mortality worldwide. Pooling data from multiple studies will permit more precise estimation of the associations and more standardized categorization of exposures and covariates. From the eight studies comprising the Pooling Project for these analyses, approximately 1,753 female and 1,945 male lung cancer cases were ascertained prospectively. The association between lung cancer and fruits and vegetables will be evaluated to determine whether specific fruits and vegetables, rather than total consumption, are most strongly related to lung cancer risk. Due to the recent controversy surrounding the association between B-carotene and lung cancer, the relationship with individual carotenoids will be assessed. Relationships with vitamins A, C and E, fat, cholesterol and alcohol also will be evaluated. A methods development aim is to use new analyses of diet diversity and diet indices to examine the effects of total diet, rather than individual components. For each exposure effect modification by smoking status and gender will be examined. These analyses will take full advantage of extensive data already collected in the individual cohorts to provide a powerful analysis of the relation between diet and lung cancer.

描述：（申请人的描述）候选人：Stephanie Smith-Warner 获得流行病学博士学位，重点研究营养学 流行病学，来自明尼苏达大学。 她曾参与过 进行过多种类型的流行病学研究，并具有以下经验： 研究设计、问卷开发、数据管理和 数据分析。 史密斯-华纳博士有兴趣加强她的研究 作为独立研究员在以下领域的背景和发展 癌症流行病学和营养流行病学。 环境：David J. Hunter 博士，现任池化项目负责人 项目已同意成为该提案的发起人。 亨特博士有 在指导研究生和博士后方面拥有丰富的经验 在不同的研究领域。 此外，该项目的主要研究人员 汇集项目中包含的个别研究对 扩大合作以评估饮食和肺癌的关联。 最后，哈佛大学公共学院营养系的教师 卫生部门积极与其他部门的科学家合作 机构。 这种多方面的协作环境提供了独特的 进一步加强史密斯-华纳博士的研究培训的机会。 研究提案：该提案建立在现有的池化项目的基础上 前瞻性研究和癌症评估饮食与癌症之间的关联 肺癌，全球死亡的主要原因。 汇集数据来自 多项研究将允许更精确地估计关联性和 暴露和协变量的更加标准化的分类。 从 八项研究组成了这些分析的汇集项目， 约 1,753 名女性和 1,945 名男性肺癌病例被查明 前瞻性地。 肺癌与水果的关系 将评估蔬菜以确定特定水果和 蔬菜，而不是总消费量，与肺的关系最为密切 癌症风险。 由于最近围绕该协会的争议 B-胡萝卜素与肺癌的关系，与个体的关系 将评估类胡萝卜素。 与维生素 A、C 和 E、脂肪的关系， 胆固醇和酒精也将被评估。 方法开发目标 是利用饮食多样性和饮食指数的新分析来检查 总体饮食的影响，而不是单个成分的影响。 对于每次曝光 将检查吸烟状况和性别对效果的影响。 这些 分析将充分利用已收集的大量数据 各个队列提供对之间关系的有力分析 饮食与肺癌。

项目成果

Dairy foods, calcium, and colorectal cancer: a pooled analysis of 10 cohort studies.

乳制品、钙和结直肠癌：10 项队列研究的汇总分析。

• DOI: 10.1093/jnci/djh185
• 发表时间: 2004-07-07
• 期刊: Journal of the National Cancer Institute
• 作者: E. Cho;S. Smith;S. Smith;D. Spiegelman;W. Beeson;P. Br;t;t;G. Colditz;A. Folsom
• 通讯作者: A. Folsom

Alcohol intake and colorectal cancer: a pooled analysis of 8 cohort studies.

酒精摄入量与结直肠癌：8 项队列研究的汇总分析。

• 发表时间: 2004-04-20
• 影响因子: 39.2
• 作者: Cho, Eunyoung;Smith;Ritz, John;van den Brandt, Piet A;Colditz, Graham A;Folsom, Aaron R;Freudenheim, Jo L;Giovannucci, Edward;Goldbohm, R Alexandra;Graham, Saxon;Holmberg, Lars;Kim, Dong;Malila, Nea;Miller, Anthony B
• 通讯作者: Miller, Anthony B

Dietary fat and risk of lung cancer in a pooled analysis of prospective studies.

前瞻性研究的汇总分析中的膳食脂肪和肺癌风险。

• 发表时间: 2002-10
• 作者: Smith;Ritz, John;Hunter, David J;Albanes, Demetrius;Beeson, W Lawrence;van den Brandt, Piet A;Colditz, Graham;Folsom, Aaron R;Fraser, Gary E;Freudenheim, Jo L;Giovannucci, Edward;Goldbohm, R Alexandra;Graham, Saxon;Kushi
• 通讯作者: Kushi

Dietary fiber intake and risk of colorectal cancer: a pooled analysis of prospective cohort studies.

膳食纤维摄入量和结直肠癌风险：前瞻性队列研究的汇总分析。

• DOI: 10.1001/jama.294.22.2849
• 发表时间: 2005-12-14
• 期刊: JAMA
• 作者: Yikyung Park;Yikyung Park;D. Hunter;D. Spiegelman;L. Bergkvist;F. Berrino;P. Br;t;t;J. Buring;G. Colditz;J. Freudenheim;C. Fuchs;E. Giovannucci;R. Goldbohm;S. Graham;L. Harnack;A. Hartman;D. Jacobs;I. Kato;V. Krogh;M. Leitzmann;M. McCullough;A. Miller;P. Pietinen;T. Rohan;A. Schatzkin;W. Willett;A. Wolk;A. Zeleniuch‐Jacquotte;Shumin M. Zhang;S. Smith
• 通讯作者: S. Smith

Dietary carotenoids and risk of colorectal cancer in a pooled analysis of 11 cohort studies.

对 11 项队列研究进行汇总分析，了解膳食类胡萝卜素与结直肠癌风险。

• DOI: 10.1093/aje/kwk009
• 发表时间: 2024-09-14
• 期刊: American journal of epidemiology
• 影响因子: 5
• 作者: S. Männistö;S. Yaun;D. Hunter;D. Spiegelman;H. Adami;D. Albanes;P. A. van den Br;t;t;J. Buring;J. Cerhan;G. Colditz;J. Freudenheim;C. Fuchs;E. Giovannucci;R. Goldbohm;L. Harnack;M. Leitzmann;M. McCullough;A. Miller;T. Rohan;A. Schatzkin;J. Virtamo;W. Willett;A. Wolk;Shumin M. Zhang;S. Smith
• 通讯作者: S. Smith