Sleep-wake disturbances in breast cancer survivors

乳腺癌幸存者的睡眠-觉醒障碍

• 批准号: 7110537
• 负责人: JULIE L Otte
• 金额: $ 2.92万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-02 至 2009-05-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7110537
• 关键词: actigraphy; behavioral /social science research tag; breast neoplasms; clinical research; environmental stressor; female; hot flash; human subject; predoctoral investigator; prognosis; psychological aspect of cancer; psychophysiology; questionnaires; sleep deprivation; sleep disorders; women' s health

DESCRIPTION (provided by applicant): Sleep-wake disturbances, defined as disruptions in nocturnal rest that result in daytime physical, psychological, and/or social dysfunction, are a significant problem for breast cancer survivors (BCS). Consequences of sleep-wake disturbances can be immediate or delayed, affecting general physiological, social and/or emotional functioning. However, it is unclear whether the prevalence of sleep-wake disturbances differs between BCS and healthy women. In addition, there is a lack of knowledge regarding the relationships among predictors of sleep-wake disturbances in BCS and healthy women (HW). Lack of knowledge of predictors of sleep-wake disturbances and how they may differ from predictors in HW makes it difficult to design and target interventions specifically for BCS. Therefore, this training plan and research will investigate and compare sleep-wake disturbances and their predictors in BCS and HW. The central aims and hypotheses will be tested using standardized self-report questionnaires and objective measurement (wrist actigraph). Specific aims are as follows: Aim 1: To compare sleep-wake disturbances between BCS and HW; Aim 2: To determine predictors of sleep-wake disturbances in BCS and HW; Aim 3: To determine whether predictors of sleep-wake disturbances differ between BCS and HW.

描述（由申请人提供）：睡眠-觉醒障碍被定义为导致白天身体、心理和/或社交功能障碍的夜间休息中断，是乳腺癌幸存者 (BCS) 面临的一个重大问题。睡眠-觉醒障碍的后果可能是立即的，也可能是延迟的，影响一般的生理、社交和/或情绪功能。然而，尚不清楚 BCS 和健康女性之间睡眠-觉醒障碍的患病率是否存在差异。此外，对于 BCS 和健康女性 (HW) 睡眠-觉醒障碍预测因子之间的关系缺乏了解。由于缺乏对睡眠-觉醒障碍的预测因子以及它们与 HW 预测因子有何不同的了解，因此很难专门针对 BCS 设计和定位干预措施。因此，本训练计划和研究将调查和比较 BCS 和 HW 中的睡眠-觉醒障碍及其预测因素。将使用标准化自我报告问卷和客观测量（手腕活动记录仪）来测试中心目标和假设。具体目标如下： 目标1：比较BCS和HW之间的睡眠-觉醒障碍；目标 2：确定 BCS 和 HW 中睡眠-觉醒障碍的预测因子；目标 3：确定 BCS 和 HW 之间睡眠-觉醒障碍的预测因素是否不同。