Accuracy of Physical Activity Measures in Cancer Studies

癌症研究中体力活动测量的准确性

• 批准号: 7086312
• 负责人: BARBARA STERNFELD
• 金额: $ 57.57万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7086312
• 关键词: actigraphy; automated data processing; behavioral /social science research tag; body composition; body physical activity; breast neoplasms; cancer risk; clinical research; data collection methodology /evaluation; human subject; interview; patient oriented research; personal log /diary; prostate neoplasms; statistics /biometry

DESCRIPTION (provided by applicant): Methodological challenges inherent in the assessment of physical activity in epidemiological studies introduce measurement errors that limit our understanding of the role of physical activity in reducing the risk of cancer and other diseases. The primary goal of this proposal is to identify and quantify the measurement error associated with two self administered physical activity (PA) questionnaires used to assess recent activity in two on-going cancer cohort studies (Life After Cancer Epidemiology Study, funded by the NCI, and the California Men's Health Study, funded by the California Cancer Research Program). To achieve this goal, we propose to conduct a validation study involving comparisons of the two test questionnaires with 1) 14 days of physical activity diaries (2 7-day periods, 5-6 months apart); 2) 14 days of accelerometer recordings, simultaneous with the PA diaries; 3) aerobic capacity as determined from a sub-maximal graded exercise treadmill test; and 4) body size measurements (body mass index, % body fat from bioelectric impedance, and waist circumference). The validation study will also include evaluation of 2-4 week test-retest repeatability of the two questionnaires. The study participants will be randomly drawn from the Northern California Kaiser Permanente (KP) Cancer Registry and general membership files and will consist of 400 women and men, ages 45-65, diagnosed with breast or prostate cancer 24-36 months prior to recruitment, and 400 women and men of similar age but with no history of cancer. The sample is expected to reflect the racial/ethnic diversity of the KP membership. In addition, we propose to develop an application program for a hand-held computer (personal digital assistant or PDA) that will be used for the collection and management of the PA diaries. We will evaluate the comparability of the PA diaries collected on the PDAs with traditional paper and pen diaries in a pilot study prior to the validation study. For the pilot study, 50 men and women, randomly drawn from the same sampling frame to be used in the validation study, will record their activities for a 4-day period in each of 3 consecutive weeks, with half using PDAs for two of the periods and paper and pen for one period, and the other half doing the reverse. The pilot study participants will also complete a cognitive interview to provide insights into the usability of the PDA software and the thought processes required in the recall of physical activity by the two test questionnaires. Sources of measurement error in the questionnaires will be identified and quantified, and statistical methods for adjusting for measurement error will be applied to the parent studies to estimate the risk of disease (breast cancer recurrence or incident prostate cancer) associated with physical activity. Because the validation will be conducted in a large, diverse, randomly selected sample, the findings may be potentially generalizable to other studies of physical activity and cancer, and may have broad applicability for studies of physical activity and other health outcomes as well.

描述（由申请人提供）：流行病学研究中身体活动评估固有的方法学挑战引入了测量误差，限制了我们对身体活动在降低癌症和其他疾病风险方面的作用的理解。该提案的主要目标是识别和量化与两项自我管理体力活动 (PA) 问卷相关的测量误差，该问卷用于评估两项正在进行的癌症队列研究（癌症流行病学研究，由 NCI 资助，以及由加州癌症研究计划资助的加州男性健康研究）。为了实现这一目标，我们建议进行一项验证研究，将两份测试问卷与以下内容进行比较：1）14 天的身体活动日记（2 个 7 天的周期，间隔 5-6 个月）； 2) 14 天的加速度计记录，与 PA 日记同时进行； 3) 通过次最大分级运动跑步机测试确定的有氧能力； 4) 身体尺寸测量（体重指数、生物电阻抗的体脂百分比和腰围）。验证研究还将包括评估两份问卷的 2-4 周重测重复性。研究参与者将从北加州 Kaiser Permanente (KP) 癌症登记处和一般会员档案中随机抽取，包括 400 名女性和男性，年龄 45-65 岁，在招募前 24-36 个月被诊断患有乳腺癌或前列腺癌，以及 400 名年龄相仿但没有癌症病史的女性和男性。该样本预计将反映 KP 成员的种族/民族多样性。此外，我们建议开发一个用于手持计算机（个人数字助理或PDA）的应用程序，用于收集和管理PA日记。在验证研究之前，我们将在试点研究中评估 PDA 上收集的 PA 日记与传统纸笔日记的可比性。在试点研究中，从用于验证研究的同一抽样框架中随机抽取 50 名男性和女性，他们将在连续 3 周的每 4 天时间内记录他们的活动，其中一半人在其中两周使用 PDA一个学期用纸和笔，另一半则相反。试点研究参与者还将完成认知访谈，以深入了解 PDA 软件的可用性以及通过两份测试问卷回忆身体活动所需的思维过程。调查问卷中测量误差的来源将被识别和量化，并且用于调整测量误差的统计方法将应用于母研究，以估计与体力活动相关的疾病风险（乳腺癌复发或前列腺癌发生）。由于验证将在大量、多样化、随机选择的样本中进行，因此研究结果可能会推广到身体活动和癌症的其他研究，并且也可能对身体活动和其他健康结果的研究具有广泛的适用性。