CORTICAL-SUBCORTICAL INTERACTION IN PD AND NORMAL SPEECH

PD 和正常言语中的皮质-皮质下相互作用

• 批准号: 7788161
• 负责人: JOHN J SIDTIS
• 金额: $ 37.93万
• 依托单位: NATHAN S. KLINE INSTITUTE FOR PSYCH RES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7788161
• 关键词: Acoustics; Address; Affect; Area; Bilateral; Brain; Brain Mapping; Brain region; Cerebrovascular Circulation; Characteristics; Clinical; Complement; Complex; Corpus striatum structure; Data; Deep Brain Stimulation; Foundations; Functional Imaging; Gestures; Globus Pallidus; Goals; Image; Inferior; Inferior frontal gyrus; Language; Lead; Left; Lesion; Linguistics; Logic; Measurement; Measures; Modeling; Motor; Nature; Parkinson Disease; Pattern; Performance; Play; Positron-Emission Tomography; Production; Research Personnel; Role; Sampling; Scanning; Series; Shapes; Speech; Speech Disorders; Structure; Structure of subthalamic nucleus; Symptoms; System; Testing; Thalamic Nuclei; Thalamic structure; Work; base; caudate nucleus; insight; motor control; nervous system disorder; phrases; predictive modeling; programs

The proposed studies will investigate interactions between cortical and subcortical brain regions during speech production by measuring regional cerebral blood flow (rCBF) with positron emission tomography (PET) in Parkinson's disease (PD) subjects, PD subjects with deep brain stimulation (DBS) of the subthalamic nuclei (STN), and normal subjects. The use of DBS of the STN to treat PD provides a reversible means of modifying the activity of sub-cortical areas including the striatum, globus pallidus, and thalamus. While effective in reducing non-speech motor symptoms, this form of therapy often has no effect or even a negative effect on speech, raising questions about the relationship between speech and non- speech motor control in PD, and more generally, about the nature of cortical-subcortical interactions during speech. We have previously observed a reliable inverse relationship between rCBF in the caudate and inferior frontal area as a function of speech rate in normal and ataxic speakers. The proposed studies will further explore this relationship and the ways in which it is altered by PD and by DBS of the STN by mapping brain activity during a series of controlled speech production tasks. The concurrent measurement and subsequent analysis of rCBF and speech production has already produced significant insight into the functional significance of imaging data. The proposed studies should yield significant ^progress in understanding cortical-subcortical interactions during speech in normal speakers andin speakers whose fluency has been affected by PD and DBS. This project will also characterizehow such interactions are affected by task demands, and how PD, DBS, and task demands interact. The goal is to better understand cbrtical-subcprtical interactions in normal and dysfluent speech, and the role of-such interactions in specific aspects of speech production. The ability to speak clearly involves a complex brain system that is not fully understood. Parkinson's Disease interferes with this ability. This researchwill study the effects of Parkinson's Disease and one formof treatment on brain activity during speech to better understand this system. This may lead to new therapies for speech disorders in neurological diseases.

拟议的研究将研究皮质和皮层下脑区域之间的相互作用 通过正电子发射断层扫描测量区域脑血流（RCBF）来产生语音 （PET）帕金森氏病（PD）受试者，具有深脑刺激（DBS）的PD受试者 丘脑下核（STN）和正常受试者。使用STN的DB来治疗PD提供了 可逆的方法，用于修改纹状体，Globus Pallidus和 丘脑。虽然有效减少非语音运动症状，但这种形式的治疗通常没有影响 甚至对语音产生负面影响，提出有关语音与非语言之间关系的问题 PD中的语音运动控制，更普遍地是关于皮质皮质相互作用的性质 演讲。我们以前已经观察到尾状RCBF之间的可靠反关系， 下部面积是正常和共同说话者的语音率的函数。拟议的研究将 进一步探索这种关系以及通过映射通过PD和STN的DB改变的关系的方式 一系列受控的语音生产任务中的大脑活动。并发测量和 随后对RCBF和语音产生的分析已经对 成像数据的功能意义。拟议的研究应在 在普通扬声器和扬声器中，了解语音的皮质增生相互作用 流利性受PD和DB的影响。这个项目还将表征这种互动的方式 受任务需求的影响以及PD，DB和任务要求如何相互作用。目标是更好地了解 正常语音和异常语音中的cbractic-subccractic相互作用，以及特定相互作用的作用 语音生产的各个方面。 说话的能力清楚地涉及一个不完全理解的复杂大脑系统。帕金森氏病 干扰这种能力。这项研究意外研究了帕金森氏病和一种形式的影响 在语音过程中对大脑活动的治疗，以更好地了解该系统。这可能会导致新疗法 用于神经疾病中的语音障碍。