CORTICAL-SUBCORTICAL INTERACTION IN PD AND NORMAL SPEECH

PD 和正常言语中的皮质-皮质下相互作用

• 批准号: 7094753
• 负责人: JOHN J SIDTIS
• 金额: $ 37.14万
• 依托单位: NATHAN S. KLINE INSTITUTE FOR PSYCH RES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7094753
• 关键词: brain; clinical research; speech

DESCRIPTION (provided by applicant): The proposed studies will investigate interactions between cortical and subcortical brain regions during speech production by measuring regional cerebral blood flow (rCBF) with positron emission tomography (PET) in Parkinson's disease (PD) subjects, PD subjects with deep brain stimulation (DBS) of the subthalamic nuclei (STN), and normal subjects. The use of DBS of the STN to treat PD provides a reversible means of modifying the activity of sub-cortical areas including the striatum, globus pallidus, and thalamus. While effective in reducing non-speech motor symptoms, this form of therapy often has no effect or even a negative effect on speech, raising questions about the relationship between speech and non- speech motor control in PD, and more generally, about the nature of cortical-subcortical interactions during speech. We have previously observed a reliable inverse relationship between rCBF in the caudate and inferior frontal area as a function of speech rate in normal and ataxic speakers. The proposed studies will further explore this relationship and the ways in which it is altered by PD and by DBS of the STN by mapping brain activity during a series of controlled speech production tasks. The concurrent measurement and subsequent analysis of rCBF and speech production has already produced significant insight into the functional significance of imaging data. The proposed studies should yield significant progress in understanding cortical-subcortical interactions during speech in normal speakers and in speakers whose fluency has been affected by PD and DBS. This project will also characterize how such interactions are affected by task demands, and how PD, DBS, and task demands interact. The goal is to better understand cortical-subcortical interactions in normal and dysfluent speech, and the role of-such interactions in specific aspects of speech production. The ability to speak clearly involves a complex brain system that is not fully understood. Parkinson's disease interferes with this ability. This research will study the effects of Parkinson's disease and one form of treatment on brain activity during speech to better understand this system. This may lead to new therapies for speech disorders in neurological diseases.

描述（由申请人提供）：拟议的研究将通过测量帕金森氏病（PD）受试者，PD受试者，深度脑刺激（DBS）和正常受试者（STN）和正常受试者的PD受试者（PD）受试者（PD）受试者（PD）受试者（PD）受试者（PD）受试者（PD）中的正电子发射断层扫描（PET），调查言语生产过程中皮质和皮质下脑区域之间的相互作用。使用STN的DBS治疗PD提供了一种可逆的方法，可以修改纹状体，Globus Pallidus和Thalamus等皮质区域的活性。尽管有效减少非语音运动症状，但这种形式的治疗通常对言语没有影响甚至负面影响，提出了有关PD中语音与非语音运动控制之间的关系的问题，更普遍地对言语中皮质性相互作用的性质提出了问题。我们先前已经观察到尾状和下额叶区域中RCBF之间的可靠反相关关系，这是正常扬声器和共同扬声器中语音率的函数。拟议的研究将进一步探讨这种关系以及通过在一系列受控的语音生产任务中绘制大脑活动来通过PD和STN的DB改变的关系。对RCBF和语音产生的同时测量和后续分析已经对成像数据的功能意义产生了重大洞察力。拟议的研究应在普通说话者的语音和流利者受到PD和DBS影响的说话者中的语音期间的皮质增生相互作用方面产生重大进展。该项目还将表征这种互动如何受到任务需求的影响，以及PD，DB和任务需求如何相互作用。目的是更好地理解正常和功能障碍语音中皮质皮质相互作用，以及在语音生产的特定方面中类似相互作用的作用。说话的能力清楚地涉及一个不完全理解的复杂大脑系统。帕金森氏病干扰了这种能力。这项研究将研究帕金森氏病和一种形式的治疗对语音期间大脑活动的影响，以更好地了解该系统。这可能会导致神经疾病中语音疾病的新疗法。