INITIATIVE TO DECREASE CARDIOVASCULAR RISK AND INCREASE QUALITY OF CARE

降低心血管风险并提高护理质量的举措

• 批准号: 7954002
• 负责人: STEVEN K. GRINSPOON
• 金额: $ 0.38万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-02-01 至 2010-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7954002
• 关键词: Anti-Retroviral Agents; Body Composition; Cardiovascular Diseases; Computer Retrieval of Information on Scientific Projects Database; Coronary heart disease; Detection; Dyslipidemias; Elderly; Fatty acid glycerol esters; Funding; Grant; Guidelines; HIV; Incidence; Inflammation; Institution; Insulin Resistance; Life; Mass Spectrum Analysis; Morbidity - disease rate; Pathogenesis; Patients; Pharmaceutical Preparations; Population; Prevention; Quality of Care; Reporting; Research; Research Personnel; Resources; Risk; Risk Factors; Screening procedure; Smoking; Source; Stratification; United States National Institutes of Health; Virus; Visceral; antiretroviral therapy; biomedical resource; cardiovascular risk factor; design; impaired glucose tolerance; mortality; subcutaneous

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. With successful antiretroviral therapy, patients infected with the human immunodeficiency virus (HIV) are living longer; however, recent reports suggest increased rates of coronary heart disease (CHD) among HIV-infected patients,1 and cardiovascular disease has become an important cause of morbidity and mortality in this population.2 Increased CHD rates in the HIV population may relate to traditional risk factors, including advancing age, higher smoking rates, dyslipidemia, insulin resistance, and impaired glucose tolerance. Cardiovascular disease may also be due to nontraditional factors, including changes in body composition with loss of subcutaneous fat and/or accumulation of visceral fat in some patients, inflammation, and direct effects of the virus on the vasculature, as well as to direct effects of specific antiretroviral drugs. Important questions remain as to the pathogenesis, detection, and treatment of cardiovascular disease and related risk factors in HIV-infected patients. These questions concern, among other things, the design of adequate trials to determine CHD incidence and the utility of existing CHD guidelines for screening, prevention, treatment, and risk stratification.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 通过成功的抗逆转录病毒疗法，感染了人类免疫缺陷病毒（HIV）的患者的寿命更长。然而，最近的报道表明，在艾滋病毒感染的患者中，冠状动脉心脏病（CHD）的发生率提高，1和心血管疾病已成为该人群中发病率和死亡率的重要原因。2HIV人群中的冠心病率提高可能与传统危险因素有关，包括增长，包括年龄，吸烟率更高，血脂异常，抑制性耐药性和耐药性。心血管疾病也可能是由于非传统因素引起的，包括人体组成的变化，某些患者的皮下脂肪损失和/或内脏脂肪的积累，炎症以及病毒对脉管系统的直接影响，以及对特定抗逆转录病毒药物的直接影响。关于HIV感染患者的心血管疾病的发病机理，检测和治疗仍然存在重要问题。除其他外，这些问题涉及到适当的试验，以确定CHD发病率和现有CHD指南用于筛查，预防，治疗和风险分层的效用。