The Adolescent Master Protocol (AMP) Up Series Project

青少年大师协议 (AMP) Up 系列项目

基本信息

批准号：
10264953
负责人：
Katherine K. Tassiopoulos
金额：
$ 25.48万
依托单位：
HARVARD SCHOOL OF PUBLIC HEALTH
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-18 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10264953
关键词：
15 year old 18 year old Address Adherence Adolescence Adolescent Adolescent and Young Adult Adult Age Aging Alcohol consumption Anti-Retroviral Agents Behavior Body Composition Bone Density Brain Cardiac Cardiopulmonary Cardiovascular Diseases Caring Centers for Disease Control and Prevention (U.S.)Cervical Child Clinic Clinic Visits Clinical Cohort Studies Data Data Collection Disease Disease remission Emotional Enrollment Ensure Epigenetic Process Family dynamics Generations Genetic Goals Growth HIV HIV Infections HIV antiretroviral Health Health behavior outcomes Healthcare Hearing Human Papillomavirus Immunologic Factors Individual Infant Inflammatory Influentials Intervention Kidney Language Lesion Long-Term Effects Longterm Follow-up Lung Medical Mental Health Metabolic Nervous System Physiology Neurocognitive Neurologic Nutritional Oral Oral health Organ Outcome Participant Pediatric HIV/AIDS Cohort Study Perinatal Persons Pharmaceutical Preparations Postpartum Period Protocols documentation Psyche structure Publications Research Research Design Role Self Management Series Sex Behavior Sexual Maturation Sexually Transmitted Diseases Social Functioning Social support Structure Tobacco use Toxic effect Viral Viremia Visit Woman antiretroviral therapy behavioral health bone cardiovascular disorder risk cardiovascular risk factor clinical care cohort comparison group design early childhood emotional functioning flexibility follow-up health care service utilization health management high risk innovation neurodevelopment pediatric human immunodeficiency virus perinatal HIV physical conditioning pubertal timing recreational drug use reproductive reproductive outcome scale up social social structure sociodemographics substance use treatment adherence treatment response vaccine efficacy virology young adult

15 year old 18 year old Address Adherence Adolescence Adolescent Adolescent and Young Adult Adult Age Aging Alcohol consumption Anti-Retroviral Agents Behavior Body Composition Bone Density Brain Cardiac Cardiopulmonary Cardiovascular Diseases Caring Centers for Disease Control and Prevention (U.S.)Cervical Child Clinic Clinic Visits Clinical Cohort Studies Data Data Collection Disease Disease remission Emotional Enrollment Ensure Epigenetic Process Family dynamics Generations Genetic Goals Growth HIV HIV Infections HIV antiretroviral Health Health behavior outcomes Healthcare Hearing Human Papillomavirus Immunologic Factors Individual Infant Inflammatory Influentials Intervention Kidney Language Lesion Long-Term Effects Longterm Follow-up Lung Medical Mental Health Metabolic Nervous System Physiology Neurocognitive Neurologic Nutritional Oral Oral health Organ Outcome Participant Pediatric HIV/AIDS Cohort Study Perinatal Persons Pharmaceutical Preparations Postpartum Period Protocols documentation Psyche structure Publications Research Research Design Role Self Management Series Sex Behavior Sexual Maturation Sexually Transmitted Diseases Social Functioning Social support Structure Tobacco use Toxic effect Viral Viremia Visit Woman antiretroviral therapy behavioral health bone cardiovascular disorder risk cardiovascular risk factor clinical care cohort comparison group design early childhood emotional functioning flexibility follow-up health care service utilization health management high risk innovation neurodevelopment pediatric human immunodeficiency virus perinatal HIV physical conditioning pubertal timing recreational drug use reproductive reproductive outcome scale up social social structure sociodemographics substance use treatment adherence treatment response vaccine efficacy virology young adult

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项目摘要

PROJECT SUMMARY The Centers for Disease Control and Prevention estimates that in 2016, there were 11,915 persons with perinatally-acquired HIV (PHIV) in the U.S., including 10,101 adolescents and young adults. Globally, 1.7 million children under the age of 15 are living with HIV and with effective antiretroviral medications (ARVs) are expected to survive into adolescence, young adulthood and beyond. The Adolescent Master Protocol (AMP) was designed to evaluate long-term effects of HIV infection and ARVs on multiple domains. AMP enrolled 451 children with PHIV between ages 7-16 years and 227 children living with perinatal HIV exposure but uninfected (PHEU) from 2007-09. The AMP Up and AMP Up Lite studies (AMP Up Series) were developed to allow for continued follow-up of young adults with PHIV (YAPHIV) beyond 18 years of age, including AMP participants, to assess physical and mental health as they transition to adulthood. These innovative studies share similar objectives and are designed to facilitate long- term follow-up with annual online and medical chart abstracted data collection. AMP has been highly productive with numerous influential publications. AMP Up has yielded important information – including the role of social support and ability to self-manage health care on a successful transition to adult clinical care, and the high risk of postpartum viremia and early HPV-associated cervical lesions. Yet the long-term effects of HIV and ARV on health in young adulthood are still unfolding. The comprehensive data collected since early childhood on a substantial subset of AMP Up participants previously in AMP provides the invaluable opportunity to assess how early HIV and ARV, mental health, neurocognitive function, and family dynamics impact adult outcomes. The specific aims of the AMP Up Series are to: 1. Define the impact of PHIV infection, ARVs, and individual, social and structural factors on: the transition to adulthood and adult care; brain structure and neurological functioning; academic, vocational, emotional and social functioning; mental health; medication and health care adherence; sexual behaviors; and substance use. 2. Identify infectious and non-infectious complications of HIV and their associations with ARVs and HIV. 3. Investigate genetic, epigenetic, virologic, inflammatory, and immunologic factors which impact the course of HIV infection, its complications, the response to treatment, and potential for HIV remission/cure.

项目摘要疾病控制与预防中心估计，2016年有11,915人在美国，围产期获得的艾滋病毒（PHIV），包括10,101名青少年和年轻人。全球，1.7 15岁以下的百万儿童患有艾滋病毒和有效的抗逆转录病毒药物（ARV）为预计将生存到青少年，年轻的成年及以后。青少年主协议（AMP）旨在评估艾滋病毒感染的长期影响和多个域上的ARV。 AMP注册了451名7-16岁之间的pHIV儿童和227名儿童生活在围产期艾滋病毒的暴露中，但未感染（PHEU）从2007 - 09年开始。放大器和放大器开发了研究（AMP UP系列），以允许对PHIV的年轻人继续进行随访（yaphiv）超过18岁，包括AMP参与者，以评估身心健康过渡到成年。这些创新研究具有相似的目标，旨在促进长期年度在线和医疗图表摘要数据收集的术语随访。 AMP的生产力很高，具有众多影响力的出版物。 AMP UP产生了重要信息 - 包括社会支持的作用和自我管理医疗保健对成功的能力过渡到成人临床护理，以及产后病毒血症和早期HPV相关的宫颈的高风险病变。然而，艾滋病毒和ARV对成年年轻人健康的长期影响仍在发展。这自童年以来收集的综合数据以前是大量AMP参与者的大量子集在AMP中提供了无价的机会来评估早期艾滋病毒和ARV，心理健康，神经认知的方式功能和家庭动态影响成人的结果。 AMP UP系列的具体目的是： 1。定义pHIV感染，ARV以及个人，社会和结构因素对：过渡到：成年和成人护理；大脑结构和神经功能；学术，职业，情感和社会功能；心理健康；药物和医疗保健依从性；性行为；和物质使用。 2。确定艾滋病毒的传染性和非感染并发症及其与ARV和艾滋病毒的关联。 3。研究影响进程的遗传，表观遗传学，病毒学，炎症和免疫因素 HIV感染，其并发症，对治疗的反应以及HIV缓解/治愈的潜力。