COVID-19 and the MWCCS: Pathophysiology, Impact and Outcomes

COVID-19 和 MWCCS：病理生理学、影响和结果

• 批准号: 10223572
• 负责人: Jeremy James Martinson
• 金额: $ 35.96万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10223572
• 关键词: 2019-nCoV; Address; Admission activity; Adult Respiratory Distress Syndrome; Affect; African American; Age; Aging; Alleles; Angiotensin-Converting Enzyme Inhibitors; Anti-Retroviral Agents; Antiviral Agents; Anxiety; Appointment; Area; Azithromycin; Biological Markers; Blood; Body Composition; COVID-19; COVID-19 pandemic; Cardiac; Cardiomyopathies; Cardiovascular system; Cessation of life; Chloroquine; Chronic lung disease; Clinical; Coagulation Process; Cohort Studies; Congestive Heart Failure; Data; Development; Diabetes Mellitus; Disease; Epidemic; Estrogens; Ethnic Origin; Exposure to; Fibrinogen; Functional disorder; Genetic; Genetic Risk; Genotype; Geographic Locations; Geography; Goals; Guide prevention; HIV; HIV Infections; HIV Seronegativity; HIV Seropositivity; Health Insurance; Healthcare; Heart Diseases; Hepatitis B Virus; Hepatitis C virus; High Prevalence; Hospitalization; Hydroxychloroquine; Hypertension; Immune; Impairment; Incidence; Individual; Infection; Inflammation; Integration Host Factors; Intensive Care Units; Interruption; Kidney; Knowledge; Lopinavir/Ritonavir; Lung; Measures; Mechanical ventilation; Mental Depression; Morbidity - disease rate; National Heart, Lung, and Blood Institute; Neurocognitive; Neurologic; Obesity; Organ; Outcome; Participant; Patients; Personal Satisfaction; Physical Function; Population; Poverty Areas; Race; Recommendation; Recovery; Reporting; Research; Respiratory physiology; Ribavirin; Risk; Risk Factors; Running; Severe Acute Respiratory Syndrome; Severities; Severity of illness; Smoking; Social support; Specimen; Spirometry; Survivors; Symptoms; System; Time; Viral; Woman; apolipoprotein E-4; biobank; cerebrovascular; clinical predictors; co-infection; cohort; comorbidity; coronavirus disease; ethnic diversity; experience; genetic risk factor; genome wide association study; health care availability; health difference; immune activation; men; metropolitan; mortality; pandemic disease; racial and ethnic; racial disparity; remdesivir; respiratory; response; sex

COVID-19 and the MWCCS: Pathophysiology, Impact and Outcomes ABSTRACT COVID-19 cases continue to rise, with over 3,000,000 cases and 130,000 deaths in the US[1] and almost 12 million cases worldwide[2] to date. Manifestations of SARS CoV-2 infection range from asymptomatic to mild, moderate, or severe disease, and primarily affects the lung, but increasing data suggests involvement of other organ and blood systems.[3] Studies document more severe disease and higher mortality among people who are older and/or have co-morbidities, such as hypertension, diabetes, obesity, and chronic lung disease.[4-7] However, there is a paucity of data regarding the acquisition, occurrence and severity of infection among people with HIV (PWH). There is also little data to guide prevention and treatment recommendations for this population, many of whom are older and have comorbidities that may increase not only their risk for acquiring infection, but also the morbidity and mortality among those who acquire infection. Moreover, early reports suggest substantial racial disparities in US COVID-19 rates, with increases in mortality among African Americans.[8] The MACS-WIHS Combined Cohort Study (MWCCS), the largest and longest-running observational cohort of men and women living with or at risk for HIV in the US provides a unique opportunity to address important knowledge gaps in the acquisition, occurrence, severity and outcomes of COVID-19. The MWCCS is a geographically and racially/ethnically diverse cohort of aging men and women with a high prevalence of risk factors for progression to severe COVID-19 disease including hypertension, diabetes, obesity, and smoking. The MWCCS has a rich biorepository of specimens, collects rigorous clinical measures including pulmonary, cardiac, kidney, neurocognitive, and physical function, body composition and has performed cohort-wide genome association studies. The overarching goal of this application is to understand the impact of the COVID-19 epidemic among US men and women with or at risk for HIV infection and to evaluate host factors that contribute to disease acquisition, expression, severity and recovery. The proposed studies will determine COVID incidence, short-term and long-term clinical outcomes, including thrombotic and pulmonary sequelae, and how racial and geographic disparities; immune and genetic risk factors impact these outcomes in the MWCCS.

COVID-19和MWCC：病理生理，影响和结果 抽象的 COVID-19案件继续增加，美国超过3,000,000例和130,000例死亡[1]，近12例 迄今为止，全球数百万个案件[2]。 SARS COV-2感染的表现范围从无症状到轻度 中度或严重疾病，主要影响肺部，但越来越多的数据表明其他 器官和血液系统。[3]研究记录了更严重的疾病和更高的死亡率 年龄较大和/或具有合并症，例如高血压，糖尿病，肥胖和慢性肺部病。[4-7] 但是，关于收购，发生和严重性感染的数据很少 艾滋病毒（PWH）的人。几乎没有数据可以指导预防和治疗建议 人口，其中许多年龄较大，并且有合并症，不仅可能增加其获取风险 感染，以及感染者的发病率和死亡率。而且，早期报告 在美国共同19率中提出实质性的种族差异，非洲死亡率增加 美国人。[8] Macs-wihs合并队列研究（MWCC），最大，最长的运行时间 在美国，与艾滋病毒或有艾滋病毒危险的男女观察队列提供了一个独特的机会 解决Covid-19的获取，发生，严重性和结果中的重要知识差距。这 MWCCS是一个地理和种族/种族多元化的男女队列 危险因素的患病率是进展到严重的共同199疾病，包括高血压，糖尿病， 肥胖和吸烟。 MWCCS具有丰富的标本生物孔，收集了严格的临床措施 包括肺，心脏，肾脏，神经认知和身体功能，身体成分，并具有 进行了整个队列的基因组关联研究。此应用程序的总体目标是了解 美国男性和女性患有艾滋病毒感染和有风险的美国男性和女性的影响 评估有助于疾病获取，表达，严重程度和康复的宿主因素。提议 研究将确定共证的发生率，短期和长期临床结果，包括血栓形成和 肺后遗症以及种族和地理差异如何；免疫和遗传危险因素影响这些 MWCC的结果。