University of Pittsburgh MACS/WIHS CCS

匹兹堡大学 MACS/WIHS CCS

• 批准号: 10612750
• 负责人: Jeremy James Martinson
• 金额: $ 408.41万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10612750
• 关键词: AIDS prevention; Acceleration; Acquired Immunodeficiency Syndrome; Address; Adult; Affect; Age; Aging; Anatomy; Anti-Retroviral Agents; Applications Grants; Back; Behavior; Behavioral; Biological; Blood; Body Composition; Brain; Brain imaging; CD4 Positive T Lymphocytes; Cancer Survivorship; Cardiac; Cardiovascular system; Cells; Censuses; Cessation of life; Characteristics; Chronic; Clinical; Clinical Management; Clonal Expansion; Cognition; Cognitive; Cohort Studies; Collection; Complement; County; Data; Development; Drug Exposure; Education; Elderly; End stage renal failure; Enrollment; Epidemic; Epidemiology; Event; Feces; Female; Fostering; Fracture; Funding; Genetic; Genome; Guidelines; HIV; HIV Infections; HIV/AIDS; Hair; Health; Hospitalization; Immune; Immunologics; Immunosuppression; Incidence; Income; Inequality; Infrastructure; Intervention; Irrigation; Laboratories; Lead; Leadership; Life; Location; Lung; Lung diseases; Malignant Neoplasms; Malignant neoplasm of lung; Measures; Metabolic; Methods; Mission; Natural History; Neighborhoods; Neurocognitive; Ohio; Oral; Oral health; Outcome; Outcome Measure; Participant; Pathogenesis; Pattern; Persons; Phenotype; Physical Function; Plasma; Population; Poverty; Prevention; Protocols documentation; Race; Request for Applications; Research; Research Personnel; Research Project Grants; Respiratory Signs and Symptoms; Risk; Risk Factors; Role; Sleep; Specimen; Standardization; Stroke; Structure; Students; The Multicenter AIDS Cohort Study; Tissues; Tumor Tissue; United States; Universities; Urine; Viral Load result; Viral reservoir; Virus Latency; Woman; Women' s Interagency HIV Study; adjudication; cancer therapy; career; career development; cervicovaginal; clinical research site; co-infection; cognitive function; cohort; comorbidity; disability; falls; frailty; health disparity; human old age (65+); improved; innovation; insight; interest; male; men; men who have sex with men; microbiome; molecular marker; mortality; neuroimaging; novel; older men; older women; participant enrollment; pharmacologic; prevent; psychosocial; pulmonary function; resilience; sex; sleep quality

PROJECT SUMMARY/ABSTRACT The overarching strategy of the University of Pittsburgh (Pitt) clinical research site (CRS) together with our collaborative clinical site at The Ohio State University (OSU) of the Multicenter AIDS Cohort Study (MACS)/Woman’s Interagency HIV Study (WIHS) Combined Cohort Study (MACS/WIHS CCS) is to support, complement and accelerate the CCS unified scientific agenda (USA) by leveraging the strengths and scientific expertise of CRS investigators. We propose to continue to expand on our 35 years of extensive research on the natural history of HIV infection. The central hypothesis of this grant application is that, as men and women with chronic HIV infection age, they increase their risks for serious, life-shortening comorbidities beyond those of comparable age, uninfected persons, and this could differ between men and women. As directed by NIH RFA- HL-19-008, the CRS will provide robust and inclusive leadership focused on five specific aims of the USA, and targeted collaborative support for the five other aims, to improve our understanding of the epidemiologic, clinical, virologic, immunologic, and behavioral relationships of HIV infection to chronic comorbidities in men and women that represent the current HIV epidemic in the United States. The CRS will also contribute longitudinal data and biological specimens for collaborative research projects on HIV led by CCS and non-CCS investigators. This research is important to fulfill our mission of improving clinical management, increasing survival and controlling, preventing and curing HIV infection. The CRS will provide the most current and innovative epidemiological, clinical and laboratory methods and psychosocial research protocols to accomplish our 5 leadership specific aims. The Pitt/OSU CRS will be led by a triumvirate of MPIs and several CoIs with broad expertise needed to lead five highly specialized CCS USA Specific Aims (Aim 2: Pulmonary/Sleep [Morris]; Aim 3: Neurocognitive [Becker]; Aim 6: HIV/Pathogenesis [Macatangay]; Aim 7: Psychosocial [Stall]; Aim 9: Platform [Rinaldo, Kingsley]) and to provide insight for the 5 other Specific Aims (Aim 1: Cardiovascular [Kingsley, Martinson], Aim 4: Aging [Koletar], Aim 5: Cancer [Jenkins], Aim 8: Health Disparities [Krier], Aim 10: Career Development [Sluis- Cremer]. With this plan the Pitt/OSU CRS addresses the basic justification of the FOA, i.e., that the impact of HIV, its treatment, and the legacy of immune suppression need to be more fully understood to optimize the health of people living with HIV.

项目摘要/摘要 匹兹堡大学（PITT）临床研究网站（CRS）的总体策略以及我们 多中心艾滋病队列研究的俄亥俄州立大学（OSU）的合作临床现场 （MAC）/妇女的机构艾滋病毒研究（WIHS）合并队列研究（MAC/WIHS CCS）是为了支持，支持， 利用优势和科学 CRS调查人员的专业知识。我们建议继续扩大有关我们35年的广泛研究 艾滋病毒感染的自然历史。该赠款申请的核心假设是，就像 慢性艾滋病毒感染年龄，他们增加了严重，寿命合并症的风险 可比的年龄，未感染的人，男人和女人之间可能会有所不同。按照NIH rfa-的指示 HL-19-008，CRS将提供强大而包容的领导力，专注于美国的五个特定目标， 针对其他五个目标的有针对性的协作支持，以提高我们对流行病学，临床， 艾滋病毒感染与男性慢性合并症的病毒，免疫和行为关系 这代表了美国当前的艾滋病毒流行。 CRS还将贡献纵向数据和 由CCS和非CCS调查人员领导的HIV合作研究项目的生物标本。这 研究对于履行我们改善临床管理，增加生存和控制的使命很重要 预防和治愈HIV感染。 CRS将提供最新和创新的流行病学， 临床和实验室方法以及心理社会研究方案，以完成我们5个领导 目标。 PITT/OSU CRS将由MPI的Triumvirate和几个具有广泛专业知识的COI领导 铅五个高度专业的CCS美国特定目标（AIM 2：肺/睡眠[Morris]； AIM 3：神经认知 [贝克尔]；目标6：HIV/发病机理[MacAtangay]；目标7：社会心理[失速]； AIM 9：平台[Rinaldo， ]）并为其他5个具体目标提供见识（AIM 1：心血管[Kingsley，Martinson]，AIM 4：衰老[Koletar]，AIM 5：癌症[Jenkins]，AIM 8：健康差异[Krier]，AIM 10：职业发展[SLUIS-- Cremer]。 PITT/OSU CRS通过此计划解决了FOA的基本理由，即 艾滋病毒，其治疗和免疫抑制的遗产需要更充分地理解，以优化健康 患有艾滋病毒的人。