The assessment of brain functional alterations due to drug abuse/addiction with p

用 p 评估药物滥用/成瘾引起的脑功能改变

基本信息

批准号：
7712732
负责人：
Xinmai Yang
金额：
$ 21.98万
依托单位：
UNIVERSITY OF KANSAS LAWRENCE
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-01 至 2011-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7712732
关键词：
Abbreviations Animal Experiments Animal Model Animals Biological Blood Blood Volume Brain Brain Pathology Brain imaging Cerebrovascular Circulation Cocaine Cocaine Abuse Complement Core-Binding Factor DAQ Detection Drug abuse Electronics Emerging Technologies Extinction (Psychology)Functional Magnetic Resonance Imaging Goals Hand Hemoglobin Hemoglobin concentration result Image Imaging Techniques Life Light Magnetic Resonance Imaging Measurement Methods Microscopy Molecular Monitor Noise Optical Coherence Tomography Optics Oxygen Pathologic Penetration Pharmaceutical Preparations Physiological Physiology Positron-Emission Tomography Property Reporting Research Research Personnel Resolution Signal Transduction Solutions Spin Labels Structure System Techniques Time Tissues Ultrasonography Variant absorption addiction attenuation base blood oxygen level dependent cocaine use cost data acquisition diffuse optical tomography hemodynamics imaging modality improved in vivo insight neuroadaptation novel optical imaging public health relevance research study response success tomography

项目摘要

DESCRIPTION (provided by applicant): The ability to image the neuroadaptations induced by drug abuse/addiction in small animal brains noninvasively offers the opportunity to evaluate pathologic progression in a fast time frame with an improved resolution. Photoacoustic imaging (PAI) is an emerging technology to image one of the optical properties>absorption>while maintaining high resolutions in regions up to 5 cm deep. PAI has been successfully applied on noninvasively visualizing the structures of a number of different biological tissues with satisfactory sensitivity and spatial resolution. The objective of current research is to apply PAI to detect the activation of the brain due to drug abuse in in vivo small animal experiments. The long term goal is to develop PAI as a convenient, low cost, noninvasive alternative imaging method to assess brain alternations due to drug abuse/addiction, as well as to provide complementing information to fMRI and PET in some cases. Specifically, in this proposal, we will employ PAI to detect brain function alternation caused by cocaine in small animals. The specific aims of this study include (1) develop and optimize a PAI system suitable for small animal whole brain imaging; (2) perform experiments to detect small animal brain function alternations due to the cocaine use, and compare PAI images with fMRI images. During this research, both the feasibility and the reliability of PAI on the detection of small animal brain functional alternations will be explored. PUBLIC HEALTH RELEVANCE: In this study, we apply the novel photoacoustic imaging (PAI) to the detection of brain functional alternations induced by drug abuse/addiction. A whole brain PAI system will be built and optimized for this purpose. The success of this project will provide an alternative, optical-contrast-based imaging modality to investigators in the field of drug abuse/addiction at significantly lower cost than fMRI and PET.

描述（由申请人提供）：图像由小动物大脑中的药物滥用/成瘾引起的神经适应性的能力非侵入性地提供了在快速时间内评估病理发展的机会，并改善了分辨率。光声成像（PAI）是一种新兴技术，可以在高达5厘米深的区域中保持高分辨率的光学特性>吸收>吸收>。 PAI已成功地应用于具有令人满意的敏感性和空间分辨率的许多不同生物组织的结构。当前研究的目的是应用PAI检测体内小动物实验中药物滥用引起的大脑的激活。长期目标是开发PAI作为一种方便，低成本的无创替代成像方法，以评估由于药物滥用/成瘾而导致的大脑交替，并在某些情况下为fMRI和PET提供补充信息。具体而言，在此提案中，我们将采用PAI来检测小动物可卡因引起的脑功能交替。这项研究的具体目的包括（1）开发和优化适用于小动物全脑成像的PAI系统；（2）执行实验以检测可卡因使用引起的小动物脑功能交替，并将PAI图像与fMRI图像进行比较。在这项研究中，将探讨PAI检测小动物脑功能替代方案的可行性和可靠性。公共卫生相关性：在这项研究中，我们将新型的光声成像（PAI）应用于对药物滥用/成瘾引起的大脑功能交替的检测。为此，将建立和优化整个大脑PAI系统。该项目的成功将为药物滥用/成瘾领域的研究人员提供一种基于光对比的成像方式，其成本明显低于fMRI和PET。