Laser-enhanced particle-free HIFU heating

激光增强无颗粒 HIFU 加热

基本信息

  • 批准号:
    8386086
  • 负责人:
  • 金额:
    $ 7万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-07-15 至 2014-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): High intensity focused ultrasound (HIFU) therapy has emerged as a truly non-invasive medical procedure for solid tumor treatment. However, the volume of the lesion following a single HIFU sonication is small. As a result, it can take up to several hours to ablate a relatively small tumor. In addition, highly vascularized (perfused) tissues are more resistant to thermal ablation than poorly perfused areas owing to the cooling effect of blood circulation. Therefore, a prolonged heating duration will be required in highly vascularized tissues. Skin burns, which are usually limited to subcentimetre superficial burns, are also often observed after HIFU treatments because ultrasonic energy deposition reaches a local maximal at skin surface. To facilitate HIFU process and avoid or minimize skin burns, we need to enhance HIFU-induced heating in the targeted tissue at a relatively low ultrasound intensity level. The effectiveness of HIFU-induced heating is related to the local ultrasound absorption. The increase of ultrasound absorption in the targeted tissue can effectively improve the heating outcome of HIFU treatment. The injection of ultrasound contrast agents or nanoparticles into the targeted tissue has been studied as a method to increase the local ultrasound absorption and enhance HIFU heating. In the current project, we propose to evaluate a photo-enhanced particle-free technique to facilitate HIFU ablation. Our central hypothesis is that HIFU therapy can be improved by a diagnostic laser system without the injection of any micro-, or nano-particles into the body. We have two specific aims: 1) investigate and optimize photo- enhanced particle-free HIFU heating: ex vivo study; and 2) evaluate photo-enhanced particle-free HIFU heating in a rodent model. We believe that the success of the proposed research will lead to an enhanced HIFU therapy for solid tumor treatments, which include the treatment of breast tumors, prostate tumors, head and neck cancer. PUBLIC HEALTH RELEVANCE: The proposed research will evaluate a photo-enhanced particle-free high intensity focused ultrasound (HIFU) heating technique for solid tumor treatment. This new technique will enhance HIFU therapy by using a diagnostic laser system and without injecting any micro-, or nano-particles into the body. The success of the proposed research will significantly improve the current HIFU therapy.
描述(由申请人提供):高强度聚焦超声(HIFU)疗法已成为实体瘤治疗的真正非侵入性医学程序。但是,单个HIFU超声处理后病变的体积很小。结果,消融相对较小的肿瘤可能需要长达几个小时。另外,由于血液循环的冷却作用,高度血管化(灌注)组织比灌注不良的区域更具耐热区域的抵抗力。因此,在高度血管化的组织中需要延长加热持续时间。皮肤燃烧通常仅限于次级浅表烧伤,在HIFU处理后也经常观察到,因为超声能量沉积在皮肤表面达到局部最大。为了促进HIFU过程并避免或最大程度地减少皮肤燃烧,我们需要在相对较低的超声强度水平下增强靶向组织中HIFU诱导的加热。 HIFU诱导的加热的有效性与局部超声吸收有关。靶向组织中超声吸收的增加可以有效地改善HIFU处理的加热结果。已经研究了将超声对比剂或纳米颗粒注入靶向组织中的一种方法,以增加局部超声吸收并增强HIFU加热。在当前的项目中,我们建议评估一种无光增强的无粒子技术,以促进HIFU消融。我们的中心假设是,诊断激光系统可以改善HIFU治疗,而无需将任何微或纳米粒子注入体内。我们有两个具体的目的:1)调查并优化无颗粒的无颗粒HIFU加热:离体研究;和2)评估啮齿动物模型中无颗粒的光hifu加热。我们认为,拟议的研究的成功将导致对实体瘤疗法的HIFU治疗增强,其中包括乳腺肿瘤,前列腺肿瘤,头颈癌的治疗。 公共卫生相关性:拟议的研究将评估用于实体瘤处理的无光增强颗粒高强度的高强度超声(HIFU)加热技术。这种新技术将通过使用诊断激光系统来增强HIFU疗法,而无需将任何微或纳米粒子注入体内。拟议研究的成功将显着改善当前的HIFU治疗。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

暂无数据

数据更新时间:2024-06-01

Xinmai Yang的其他基金

Precisely removing microvessels by photo-mediated ultrasound therapy
光介导超声治疗精准去除微血管
  • 批准号:
    10228017
    10228017
  • 财政年份:
    2018
  • 资助金额:
    $ 7万
    $ 7万
  • 项目类别:
Precisely removing microvessels by photo-mediated ultrasound therapy
光介导超声治疗精准去除微血管
  • 批准号:
    9769058
    9769058
  • 财政年份:
    2018
  • 资助金额:
    $ 7万
    $ 7万
  • 项目类别:
Laser-enhanced particle-free HIFU heating
激光增强无颗粒 HIFU 加热
  • 批准号:
    8509687
    8509687
  • 财政年份:
    2012
  • 资助金额:
    $ 7万
    $ 7万
  • 项目类别:
Photoacoustic imaging of functional domains on primary motor cortex of monkeys
猴子初级运动皮层功能域的光声成像
  • 批准号:
    8011214
    8011214
  • 财政年份:
    2010
  • 资助金额:
    $ 7万
    $ 7万
  • 项目类别:
Photoacoustic imaging of functional domains on primary motor cortex of monkeys
猴子初级运动皮层功能域的光声成像
  • 批准号:
    7774637
    7774637
  • 财政年份:
    2010
  • 资助金额:
    $ 7万
    $ 7万
  • 项目类别:
The assessment of brain functional alterations due to drug abuse/addiction with p
用 p 评估药物滥用/成瘾引起的脑功能改变
  • 批准号:
    7712732
    7712732
  • 财政年份:
    2009
  • 资助金额:
    $ 7万
    $ 7万
  • 项目类别:

相似国自然基金

髋关节撞击综合征过度运动及机械刺激动物模型建立与相关致病机制研究
  • 批准号:
    82372496
  • 批准年份:
    2023
  • 资助金额:
    48 万元
  • 项目类别:
    面上项目
利用碱基编辑器治疗肥厚型心肌病的动物模型研究
  • 批准号:
    82300396
  • 批准年份:
    2023
  • 资助金额:
    30.00 万元
  • 项目类别:
    青年科学基金项目
利用小型猪模型评价动脉粥样硬化易感基因的作用
  • 批准号:
    32370568
  • 批准年份:
    2023
  • 资助金额:
    50.00 万元
  • 项目类别:
    面上项目
丁苯酞通过调节细胞异常自噬和凋亡来延缓脊髓性肌萎缩症动物模型脊髓运动神经元的丢失
  • 批准号:
    82360332
  • 批准年份:
    2023
  • 资助金额:
    31.00 万元
  • 项目类别:
    地区科学基金项目
APOBEC3A驱动膀胱癌发生发展的动物模型及其机制研究
  • 批准号:
    82303057
  • 批准年份:
    2023
  • 资助金额:
    30.00 万元
  • 项目类别:
    青年科学基金项目

相似海外基金

Hypothalamic Sleep-Wake Neuron Defects in Alzheimer’s disease
阿尔茨海默病中的下丘脑睡眠-觉醒神经元缺陷
  • 批准号:
    10770001
    10770001
  • 财政年份:
    2023
  • 资助金额:
    $ 7万
    $ 7万
  • 项目类别:
Investigating the role of CSF production and circulation in aging and Alzheimer's disease
研究脑脊液产生和循环在衰老和阿尔茨海默病中的作用
  • 批准号:
    10717111
    10717111
  • 财政年份:
    2023
  • 资助金额:
    $ 7万
    $ 7万
  • 项目类别:
Genetic and molecular mechanisms of Xbp-1 mediated salivary gland development and differentiation
Xbp-1介导唾液腺发育和分化的遗传和分子机制
  • 批准号:
    10678146
    10678146
  • 财政年份:
    2023
  • 资助金额:
    $ 7万
    $ 7万
  • 项目类别:
Neuroimmune axis contribution to the pathophysiology of pulmonary hypertension
神经免疫轴对肺动脉高压病理生理学的贡献
  • 批准号:
    10664323
    10664323
  • 财政年份:
    2023
  • 资助金额:
    $ 7万
    $ 7万
  • 项目类别:
Neural pathways for obesity development by AgRP neurons
AgRP 神经元导致肥胖发展的神经通路
  • 批准号:
    10681993
    10681993
  • 财政年份:
    2023
  • 资助金额:
    $ 7万
    $ 7万
  • 项目类别: