Laser-enhanced particle-free HIFU heating

激光增强无颗粒 HIFU 加热

• 批准号: 8386086
• 负责人: Xinmai Yang
• 金额: $ 7万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-15 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8386086
• 关键词: Ablation; Animal Model; Area; Blood; Blood Circulation; Burn injury; Contrast Media; Deposition; Diagnostic; Effectiveness; Focused Ultrasound Therapy; Goals; Head and Neck Cancer; Heating; Hour; Image; Immune system; Injection of therapeutic agent; Lasers; Lead; Lesion; Life; Mammary Neoplasms; Medical; Methods; Morbidity - disease rate; Needles; Neoplasm Metastasis; Operative Surgical Procedures; Outcome; Output; Patients; Perioperative; Postoperative Pain; Procedures; Process; Prostatic Neoplasms; Recovery; Research; Resistance; Risk; Rodent Model; Skin; Solid Neoplasm; Sonication; Surface; System; Techniques; Testing; Thermal Ablation Therapy; Time; Tissues; Ultrasonics; Ultrasonography; Vascular blood supply; absorption; cancer therapy; cost; design; improved; mortality; nanoparticle; particle; success; tumor

DESCRIPTION (provided by applicant): High intensity focused ultrasound (HIFU) therapy has emerged as a truly non-invasive medical procedure for solid tumor treatment. However, the volume of the lesion following a single HIFU sonication is small. As a result, it can take up to several hours to ablate a relatively small tumor. In addition, highly vascularized (perfused) tissues are more resistant to thermal ablation than poorly perfused areas owing to the cooling effect of blood circulation. Therefore, a prolonged heating duration will be required in highly vascularized tissues. Skin burns, which are usually limited to subcentimetre superficial burns, are also often observed after HIFU treatments because ultrasonic energy deposition reaches a local maximal at skin surface. To facilitate HIFU process and avoid or minimize skin burns, we need to enhance HIFU-induced heating in the targeted tissue at a relatively low ultrasound intensity level. The effectiveness of HIFU-induced heating is related to the local ultrasound absorption. The increase of ultrasound absorption in the targeted tissue can effectively improve the heating outcome of HIFU treatment. The injection of ultrasound contrast agents or nanoparticles into the targeted tissue has been studied as a method to increase the local ultrasound absorption and enhance HIFU heating. In the current project, we propose to evaluate a photo-enhanced particle-free technique to facilitate HIFU ablation. Our central hypothesis is that HIFU therapy can be improved by a diagnostic laser system without the injection of any micro-, or nano-particles into the body. We have two specific aims: 1) investigate and optimize photo- enhanced particle-free HIFU heating: ex vivo study; and 2) evaluate photo-enhanced particle-free HIFU heating in a rodent model. We believe that the success of the proposed research will lead to an enhanced HIFU therapy for solid tumor treatments, which include the treatment of breast tumors, prostate tumors, head and neck cancer. PUBLIC HEALTH RELEVANCE: The proposed research will evaluate a photo-enhanced particle-free high intensity focused ultrasound (HIFU) heating technique for solid tumor treatment. This new technique will enhance HIFU therapy by using a diagnostic laser system and without injecting any micro-, or nano-particles into the body. The success of the proposed research will significantly improve the current HIFU therapy.

描述（由申请人提供）：高强度聚焦超声（HIFU）疗法已成为一种真正的非侵入性实体瘤治疗医疗程序。然而，单次 HIFU 超声处理后的病变体积很小。因此，消融相对较小的肿瘤可能需要长达几个小时的时间。此外，由于血液循环的冷却作用，高度血管化（灌注）的组织比灌注不良的区域更能抵抗热消融。因此，高度血管化的组织需要延长加热持续时间。皮肤烧伤通常仅限于亚厘米的浅表烧伤，在 HIFU 治疗后也经常观察到，因为超声波能量沉积在皮肤表面达到局部最大值。为了促进 HIFU 过程并避免或最大程度地减少皮肤烧伤，我们需要在相对较低的超声强度水平下增强目标组织中 HIFU 诱导的加热。 HIFU 诱导加热的有效性与局部超声吸收有关。增加靶组织对超声的吸收，可以有效提高HIFU治疗的加热效果。已经研究了将超声造影剂或纳米粒子注射到目标组织中作为增加局部超声吸收和增强 HIFU 加热的方法。在当前的项目中，我们建议评估一种光增强无粒子技术以促进 HIFU 消融。我们的中心假设是，可以通过诊断激光系统来改善 HIFU 治疗，而无需向体内注射任何微米或纳米颗粒。我们有两个具体目标：1）研究和优化光增强无颗粒 HIFU 加热：离体研究； 2) 在啮齿动物模型中评估光增强无颗粒 HIFU 加热。我们相信，拟议研究的成功将导致实体瘤治疗的增强 HIFU 疗法，其中包括乳腺肿瘤、前列腺肿瘤、头颈癌的治疗。 公共健康相关性：拟议的研究将评估用于实体瘤治疗的光增强无颗粒高强度聚焦超声（HIFU）加热技术。这项新技术将通过使用诊断激光系统来增强 HIFU 治疗，并且无需向体内注射任何微米或纳米颗粒。该研究的成功将显着改善当前的 HIFU 治疗。