Laser-enhanced particle-free HIFU heating

激光增强无颗粒 HIFU 加热

• 批准号: 8386086
• 负责人: Xinmai Yang
• 金额: $ 7万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-15 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8386086
• 关键词: Ablation; Animal Model; Area; Blood; Blood Circulation; Burn injury; Contrast Media; Deposition; Diagnostic; Effectiveness; Focused Ultrasound Therapy; Goals; Head and Neck Cancer; Heating; Hour; Image; Immune system; Injection of therapeutic agent; Lasers; Lead; Lesion; Life; Mammary Neoplasms; Medical; Methods; Morbidity - disease rate; Needles; Neoplasm Metastasis; Operative Surgical Procedures; Outcome; Output; Patients; Perioperative; Postoperative Pain; Procedures; Process; Prostatic Neoplasms; Recovery; Research; Resistance; Risk; Rodent Model; Skin; Solid Neoplasm; Sonication; Surface; System; Techniques; Testing; Thermal Ablation Therapy; Time; Tissues; Ultrasonics; Ultrasonography; Vascular blood supply; absorption; cancer therapy; cost; design; improved; mortality; nanoparticle; particle; success; tumor

DESCRIPTION (provided by applicant): High intensity focused ultrasound (HIFU) therapy has emerged as a truly non-invasive medical procedure for solid tumor treatment. However, the volume of the lesion following a single HIFU sonication is small. As a result, it can take up to several hours to ablate a relatively small tumor. In addition, highly vascularized (perfused) tissues are more resistant to thermal ablation than poorly perfused areas owing to the cooling effect of blood circulation. Therefore, a prolonged heating duration will be required in highly vascularized tissues. Skin burns, which are usually limited to subcentimetre superficial burns, are also often observed after HIFU treatments because ultrasonic energy deposition reaches a local maximal at skin surface. To facilitate HIFU process and avoid or minimize skin burns, we need to enhance HIFU-induced heating in the targeted tissue at a relatively low ultrasound intensity level. The effectiveness of HIFU-induced heating is related to the local ultrasound absorption. The increase of ultrasound absorption in the targeted tissue can effectively improve the heating outcome of HIFU treatment. The injection of ultrasound contrast agents or nanoparticles into the targeted tissue has been studied as a method to increase the local ultrasound absorption and enhance HIFU heating. In the current project, we propose to evaluate a photo-enhanced particle-free technique to facilitate HIFU ablation. Our central hypothesis is that HIFU therapy can be improved by a diagnostic laser system without the injection of any micro-, or nano-particles into the body. We have two specific aims: 1) investigate and optimize photo- enhanced particle-free HIFU heating: ex vivo study; and 2) evaluate photo-enhanced particle-free HIFU heating in a rodent model. We believe that the success of the proposed research will lead to an enhanced HIFU therapy for solid tumor treatments, which include the treatment of breast tumors, prostate tumors, head and neck cancer. PUBLIC HEALTH RELEVANCE: The proposed research will evaluate a photo-enhanced particle-free high intensity focused ultrasound (HIFU) heating technique for solid tumor treatment. This new technique will enhance HIFU therapy by using a diagnostic laser system and without injecting any micro-, or nano-particles into the body. The success of the proposed research will significantly improve the current HIFU therapy.

描述（由申请人提供）：高强度聚焦超声（HIFU）疗法已成为实体瘤治疗的真正非侵入性医学程序。但是，单个HIFU超声处理后病变的体积很小。结果，消融相对较小的肿瘤可能需要长达几个小时。另外，由于血液循环的冷却作用，高度血管化（灌注）组织比灌注不良的区域更具耐热区域的抵抗力。因此，在高度血管化的组织中需要延长加热持续时间。皮肤燃烧通常仅限于次级浅表烧伤，在HIFU处理后也经常观察到，因为超声能量沉积在皮肤表面达到局部最大。为了促进HIFU过程并避免或最大程度地减少皮肤燃烧，我们需要在相对较低的超声强度水平下增强靶向组织中HIFU诱导的加热。 HIFU诱导的加热的有效性与局部超声吸收有关。靶向组织中超声吸收的增加可以有效地改善HIFU处理的加热结果。已经研究了将超声对比剂或纳米颗粒注入靶向组织中的一种方法，以增加局部超声吸收并增强HIFU加热。在当前的项目中，我们建议评估一种无光增强的无粒子技术，以促进HIFU消融。我们的中心假设是，诊断激光系统可以改善HIFU治疗，而无需将任何微或纳米粒子注入体内。我们有两个具体的目的：1）调查并优化无颗粒的无颗粒HIFU加热：离体研究；和2）评估啮齿动物模型中无颗粒的光hifu加热。我们认为，拟议的研究的成功将导致对实体瘤疗法的HIFU治疗增强，其中包括乳腺肿瘤，前列腺肿瘤，头颈癌的治疗。 公共卫生相关性：拟议的研究将评估用于实体瘤处理的无光增强颗粒高强度的高强度超声（HIFU）加热技术。这种新技术将通过使用诊断激光系统来增强HIFU疗法，而无需将任何微或纳米粒子注入体内。拟议研究的成功将显着改善当前的HIFU治疗。