Omega-3 and Blueberry Supplmentation in Age-Related Cognitive Decline

补充 Omega-3 和蓝莓可治疗与年龄相关的认知衰退

• 批准号: 7941591
• 负责人: ROBERT KRIKORIAN
• 金额: $ 11.73万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7941591
• 关键词: Adherence; Affect; Age-associated memory impairment; Aging; Alzheimer' s Disease; Animal Experimentation; Animals; Anti-Inflammatory Agents; Anti-inflammatory; Antioxidants; Autopsy; Behavior Therapy; Binding; Blueberries; Brain; Cell membrane; Clinical; Cognition; Cognitive; Cognitive aging; Data; Dementia; Dietary Supplementation; Early treatment; Elderly; Erythrocytes; Evidence based treatment; Exercise; Exhibits; Freeze Drying; Future; Health; Human; Impaired cognition; Individual; Individual Differences; Inflammation; Intervention; Investigation; Lead; Longitudinal Studies; Longitudinal Surveys; Maintenance; Membrane; Memory; Metabolic; Moods; Nerve Degeneration; Neurobiology; Neurocognitive; Neurons; Nutraceutical; Omega-3 Fatty Acids; Outcome; Participant; Pharmacologic Substance; Physiological; Placebo Control; Placebos; Population; Powder dose form; Prevalence; Prevention; Prevention strategy; Preventive; Prospective Studies; Public Health; Randomized; Relative (related person); Request for Proposals; Research; Risk; Rodent Model; Sampling; Short-Term Memory; Signal Transduction; Supplementation; Time; Transgenic Organisms; Treatment Efficacy; age related; age related cognitive change; aged; cognitive function; cognitive training; coping; daily functioning; depressive symptoms; dosage; double-blind placebo controlled trial; effective therapy; experience; improved; indexing; long term memory; neuroimaging; neuropathology; novel; placebo controlled study; pre-clinical research; preclinical study; prevent; primary outcome; progressive neurodegeneration; public health relevance; relating to nervous system; response; restoration; symptomatic improvement; therapy design; treatment trial

DESCRIPTION (provided by applicant): Older adults with age-related cognitive decline experience at least modest inefficiency in everyday functioning and have increased risk of developing dementia, in particular Alzheimer's disease (AD). With the expansion of the elderly population there is concern that the prevalence of AD may increase substantially beyond previous projections that ranged from 11 to 16 million affected individuals by the year 2050. Current pharmaceutical therapies provide only partial and transient symptomatic improvement and produce adverse responses in some individuals. At this time, early intervention represents the optimal approach for slowing or preventing further cognitive decline. Omega-3 fatty acid deficiency represents a plausible pathoetiological mechanism for neuropathology associated with cognitive aging and dementia, and omega-3 fatty acid treatment has positive effects on a number of putative mechanisms of age-related decline. In addition, basic animal research during the last decade and very recent human preliminary data indicate that blueberry supplementation produces substantial neurobiological benefit and has the potential to ameliorate age-related cognitive decline. Further, there are indications that the combined effects of these nutraceutical approaches may offer more potent additive as well as complementary benefits aimed specifically at neurodegenerative mechanisms. Our long-term objective is to develop a nutraceutical intervention strategy that can be effective when applied with older adults experiencing age-related decline. In this investigation, we will evaluate the efficacy of combined omega-3 fatty acid and blueberry supplementation in improving memory function in elderly individuals with early memory changes. We propose a 6-month randomized, double-blind, placebo-controlled trial involving daily supplementation with these nutraceutical products and longitudinal assessment up to one year after baseline. Our primary outcomes will be assessment of change in aspects of memory function and daily functioning in response to the intervention. We plan to use the findings of this study to support future, more comprehensive research examining mechanisms of action, dosage, and duration of effects in older adults. This proposal was generated in response to the NIA request for proposals to investigate novel, combined non-pharmaceutical interventions designed to improve cognitive function in older adults. PUBLIC HEALTH RELEVANCE: Evidence-based treatments are urgently needed for elderly individuals with or at risk for age-related cognitive decline. As an initial step to establish early intervention and prevention strategies, this application proposes a double-bind placebo-controlled treatment trial to evaluate the neurocognitive benefits of combined omega-3 fatty acid and blueberries in elderly subjects at risk for age-related cognitive decline.

描述（由申请人提供）：具有与年龄相关的认知下降经验至少在日常功能中效率低下的老年人，并且患有痴呆症的风险增加，尤其是阿尔茨海默氏病（AD）。随着老年人口的扩大，人们担心AD的患病率可能会大大增加，而不是先前的预测，到2050年，该预测的范围从11万至1600万个受影响的人不等。当前的药物疗法仅提供部分和短暂的症状改善，并在某些个体中产生不良反应。目前，早期干预代表了放缓或防止进一步认知下降的最佳方法。 omega-3脂肪酸缺乏代表了与认知衰老和痴呆相关的神经病理学的合理病理学机制，而omega-3脂肪酸治疗对许多与年龄相关下降的推定机制具有积极影响。此外，在过去十年中的基本动物研究以及最新的人类初步数​​据表明，补充蓝莓会产生可观的神经生物学益处，并有可能改善与年龄相关的认知能力下降。此外，有迹象表明，这些营养学方法的综合作用可能会提供更有效的添加剂和互补的益处，专门针对神经退行性机制。我们的长期目标是制定一种营养干预策略，当与年龄相关的老年人使用时，该策略可能是有效的。在这项研究中，我们将评估omega-3脂肪酸和补充蓝莓在改善具有早期记忆变化的老年人记忆功能方面的功效。我们提出了一项为期6个月的随机，双盲，安慰剂对照试验，涉及每天补充这些营养产品和纵向评估，直到基线后一年。我们的主要结果将是评估记忆功能方面的变化以及响应干预措施的日常功能。我们计划利用这项研究的结果来支持未来，更全面的研究，以研究老年人的作用，剂量和影响持续时间。该提案是根据NIA要求提出的提案来研究新型的，旨在改善老年人认知功能的新型非药物干预措施的提议的生成。 公共卫生相关性：迫切需要具有与年龄相关的认知能力下降风险或有风险的老年人，迫切需要基于证据的治疗。作为建立早期干预和预防策略的第一步，该应用提出了一项双链接安慰剂对照的治疗试验，以评估与年龄相关认知能力下降风险的老年受试者中联合omega-3脂肪酸和蓝莓的神经认知益处。