Phytoestrogens and Cognition in Menopause

植物雌激素与更年期认知

• 批准号: 6656906
• 负责人: ROBERT KRIKORIAN
• 金额: $ 19.19万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-15 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6656906
• 关键词: clinical research; clinical trials; cognition disorders; cortisol; dementia; diet therapy; dietary supplements; drug screening /evaluation; emotions; female; functional ability; hippocampus; human middle age (35-64); human old age (65+); human subject; human therapy evaluation; intelligence tests; memory; memory disorders; neuropsychological tests; nutrition related tag; patient oriented research; phytoestrogens; postmenopause; urinalysis; women's health

DESCRIPTION (provided by applicant): Estrogens produce a multitude of complex effects in the brain by means of a variety of mechanisms. Accumulating data has indicated that these actions mediate enhancing effects on cognition and mood as well as perhaps prophylaxis against age-and disease-related cognitive-cerebral decline. Phytoestrogens have demonstrated estrogenic activity. They have been studied with respect to benefits for cardiovascular function, preservation of bone, and reduction of risk for cancer, but there is little prospective research regarding effects on mental function. In addition, phytoestrogens generally are not prescribed by practitioners for mental health effects. However, many women experiencing peri-and post-menopausal symptoms consume marketed phytoestrogens, in particular soy-derived isoflavone products, under the perception of general health benefits, including presumably enhanced mental function. The goal of this exploratory research is to develop preliminary data regarding the efficacy of isoflavone phytoestrogens in producing improvement in cognitive function in late middle-aged and elderly postmenopausal women with symptoms of memory impairment and, therefore, increased risk for development of progressive dementia such as Alzheimer?s Disease. A secondary goal will be to examine changes in basal cortisol levels, as a means of assessing the effect of the intervention on an endocrine parameter that has significance for hippocampal function, particularly in the aged. We will administer a 16-week protocol of isoflavone supplementation in a randomized, double-blind, placebo-controlled study to menopausal women aged 55 to 75 years with forgetfulness and other symptoms of cognitive decline, but who do not meet criteria for probable dementia. We will assess changes in neuropsychological measures of executive function ability and episodic memory, in basal cortisol levels, and in mood. It is our expectation that the demonstration of positive responses to this intervention in this at-risk population will establish the basis for future, more comprehensive studies of dosage, mechanisms, and duration of effect. Ultimately, such research may establish the basis for the use of isoflavones as an alternative treatment that would provide mental and general health benefits without the risks associated with traditional hormone replacement therapies.

描述（申请人提供）：雌激素产生多种复杂 通过多种机制在大脑中的影响。累积数据具有 表明这些动作介导了增强对认知和情绪的影响 也许可以预防与年龄和疾病相关的认知 - 脑部 衰退。植物雌激素表现出雌激素活性。他们曾经 研究了心血管功能的好处 骨骼和癌症风险的降低，但前瞻性几乎没有 有关对心理功能的影响的研究。另外，植物雌激素 通常，从业人员不针对心理健康影响开处方。 但是，许多经历了绝经后症状的妇女消耗 销售的植物雌激素，特别是大豆衍生的异黄酮产品 对一般健康益处的看法，包括大概增强了精神 功能。这项探索性研究的目的是制定初步数据 关于异黄酮植物雌激素在产生改善的功效 中年晚期和老年绝经后妇女的认知功能 记忆障碍的症状，因此增加了发展的风险 诸如阿尔茨海默氏病等进展性痴呆症。次要目标是 检查基底皮质醇水平的变化，以评估 对内分泌参数的干预对 海马功能，特别是在老年人中。我们将管理16周 在随机，双盲中补充异黄酮的方案 对年龄55至75岁的更年期妇女的安慰剂对照研究 健忘和其他认知能力下降的症状，但谁不遇到 可能痴呆的标准。我们将评估神经心理学的变化 基底皮质醇中的执行功能能力和情节记忆的度量 水平和心情。我们期望表现为积极 对这种高危人群的这种干预的回应将确定 未来的基础，对剂量，机制和机制的更全面研究 效果持续时间。最终，此类研究可能为 使用异黄酮作为一种替代治疗方法，可提供精神和 一般健康益处，没有与传统激素相关的风险 替代疗法。