Reading and the Right Fusiform

阅读和右纺锤形

• 批准号: 7738669
• 负责人: Julie A Fiez
• 金额: $ 30.92万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-15 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7738669
• 关键词: Accounting; Acquired Alexia; Area; Behavioral; Bilateral; Chinese People; Clinical; Code; Development; Developmental reading disorder; Exhibits; Exposure to; Face; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Individual; Individual Differences; Instruction; Interdisciplinary Study; Koreans; Language; Lead; Left; Letters; Light; Maps; Measures; Methods; Nature; Orthography; Participant; Pathway interactions; Pattern; Printing; Process; Reader; Reading; Reliance; Research; Right-On; Route; Semantics; Series; Structure; System; Testing; Text; Time; Visual; Writing; design; extrastriate visual cortex; face perception; novel strategies; phonology; public health relevance; relating to nervous system; response; skills; visual process; visual processing

DESCRIPTION (provided by applicant): Years of interdisciplinary research have significantly advanced our understanding of optimal methods for reading instruction, orthographic and phonological variables that interact with word identification, and the neural substrates that support reading. However, core theoretical issues remain unresolved. For instance, a specific region in the left fusiform cortex, termed the Visual Word Form Area (VWFA), has been strongly implicated in orthographic processing. Overall, the current findings suggest the region is a core - perhaps even obligatory -- part of the pathway by which the perceptual analysis of written words ultimately provides fluent access to representations of phonology and meaning. In this proposal, we consider an alternative possibility: namely, that the right fusiform cortex can provide an alternative route through which print can gain access to the language system. We will test this hypothesis by examining the effect of cultural (Aim 1), individual (Aim 2), and orthographic (Aim 3) differences on the magnitude, time course, and functional connectivity of the right and left fusiform cortex. We will relate fusiform activity to measures of reading skill, and to behavioral markers for different types of orthographic analysis. The results should inform the theoretical debate about the VWFA, and they may lead to new approaches for the treatment of acquired and developmental reading disorders. PUBLIC HEALTH RELEVANCE: The overarching goal of the proposed research is to determine whether the right fusiform can provide an alternative route into the language system, a possibility that is raised by our findings with native Chinese speakers. The answer will shed light on the ongoing debate about the nature of the Visual Word Form Area (VWFA) and the impact of perceptual analysis upon phonological coding during reading. Longer term, the answer may also have important clinical implications: if the right fusiform can support reading independently from the left fusiform (i.e., VWFA), then it may be possible to design new approaches to the treatment of individuals with acquired or developmental dysfunction of the VWFA.

描述（由申请人提供）：多年的跨学科研究已大大提高了我们对与单词识别相互作用的阅读教学，拼字和语音变量的最佳方法的理解，以及支持阅读的神经基板。但是，核心理论问题仍未解决。例如，称为视觉单词表单区域（VWFA）的左梭形皮质中的特定区域已与拼字处理密切相关。总体而言，目前的发现表明该地区是核心 - 甚至可能是强制性的 - 书面词的感知分析最终可以流利地访问语音和意义的表示。在此提案中，我们考虑了另一种可能性：即，正确的梭形皮层可以提供一条替代路线，可以通过该路线可以访问语言系统。我们将通过研究文化（AIM 1），个体（AIM 2）和拼字法（AIM 3）在左右梭形皮层的大小，时间过程和功能连通性上的差异来检验这一假设。我们将将梭形活性与阅读技能的度量以及不同类型的拼字法分析的行为标记联系起来。结果应为有关VWFA的理论辩论提供信息，它们可能会导致对获得和发育阅读障碍的治疗的新方法。公共卫生相关性：拟议的研究的总体目标是确定正确的梭形状态是否可以为语言体系提供替代途径，这是我们与中国母语人士的发现提出的可能性。答案将阐明有关视觉单词形式区域（VWFA）性质的持续辩论以及感知分析对阅读过程中语音编码的影响。从长远来看，答案也可能具有重要的临床意义：如果合适的梭形可以从左梭形（即VWFA）独立支持阅读，那么可以设计新方法来治疗VWFA的获得或发育功能障碍的人。