Prenatal Organochlorine Metabolites, Thyroid Function and Development
产前有机氯代谢物、甲状腺功能和发育
基本信息
- 批准号:7565810
- 负责人:
- 金额:$ 55.26万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-09-15 至 2011-08-31
- 项目状态:已结题
- 来源:
- 关键词:17 year oldAccountingAdolescenceAdverse effectsAgeAge at MenarcheAnimalsAntibodiesAwardBindingBiologicalBirthBloodBody mass indexCaliforniaCarrier ProteinsChildChild health careChildhoodChlordanChlorinated HydrocarbonsCognitionConfounding Factors (Epidemiology)ConsumptionCretinismDataDevelopmentEndocrine DisruptorsEnrollmentEnvironmentEnvironmental PollutionEquationExposure toFemaleFolateFollow-Up StudiesFoundationsFreezingFunctional disorderFundingGoalsGrowthHealthHealth PlanningHeightHumanHydrocarbonsHydroxyl RadicalHypothyroidismIodide PeroxidaseKnowledgeLeadLifeLife Cycle StagesMeasuresMental RetardationMetabolismMethodsMothersNeural Tube DefectsNeurodevelopmental DeficitOutcomeParentsPerinatal ExposurePesticidesPolychlorinated BiphenylsPostpartum PeriodPrealbuminPregnancyPregnant WomenPrincipal InvestigatorProductionProperdinPublic HealthPublicationsResearchResearch PersonnelResearch Project GrantsSchizophreniaSecond Pregnancy TrimesterSerumStructureTestingThyroid Function TestsThyroid GlandThyroid HormonesThyrotropinThyroxineTimeUnited States National Institutes of HealthWeightWomancognitive functioncohortcostdesignearly childhoodemerging adultfetalfollow-upgirlshormone deficiencyin uteroinfancylongitudinal analysisneuropsychologicaloffspringorganochlorine exposurepostnatalprematureprenatalprenatal exposureprenatal interventionprogramspublic health relevance
项目摘要
DESCRIPTION (provided by applicant): The overall goal of this project is to assess whether exposure to metabolites of endocrine disrupting compounds during pregnancy is associated with a) adverse development (cognitive function, height, weight, weight for height, and for females, age at menarche) in the offspring at birth, early childhood, middle childhood, and adolescence, b) mild deficiencies in maternal thyroid function, and c) whether adverse developmental findings, if any, are attributed in part to deficiencies in exposure to maternal thyroid hormone in utero. We also aim to describe the relationships between the metabolites and parent compounds and to examine the associations between the metabolites and thyroid function in the pregnant women. The proposed study draws on data from the Child Health and Development Study, a longitudinal follow up of children born between 1959 and 1966 to mothers enrolled in the Oakland, California membership of the Kaiser Foundation Health Plan and expands upon previous NIH funded research. Prenatal sera has been appropriately frozen and stored, and are available to assess exposure to the metabolites of organochlorine compounds; exposure to organochlorine compounds and maternal thyroid function during pregnancy has already been measured. Serial measures of growth are available in the same children from birth to age 17 years, as are standardized developmental examinations at ages 5, 9-11, and 15-17. The proposed measures of organochlorine exposure and exposure to measures of maternal thyroid function (thyroid stimulating hormone, free thyroxine, and thyroid peroxidase antibodies). Statistical analyses will estimate associations taking advantage of the repeated measures structure of the data. The analyses will employ generalized estimating equations (GEE) methods for repeated measures, taking account of potentially confounding variables. We will distinguish effects of prenatal organochlorine metabolite exposures from infancy through adolescence. We will also investigate a specific mechanism: via maternal thyroid function. Results will fully describe the effects of prenatal exposure and will also further knowledge about the relation between subclinical maternal thyroid hormone deficiency and childhood development. This line of research could lead to prenatal interventions. PUBLIC HEALTH RELEVANCE: We will distinguish effects of prenatal organochlorine metabolite exposures from infancy through adolescence. We will also investigate a specific mechanism: via maternal thyroid function. Results will fully describe the effects of prenatal exposure and will also further knowledge about the relation between subclinical maternal thyroid hormone deficiency and childhood development. This line of research could lead to prenatal interventions.
描述(由申请人提供):该项目的总体目标是评估怀孕期间接触内分泌干扰化合物的代谢物是否与 a) 不良发育(认知功能、身高、体重、身高体重比以及女性的年龄)相关。初潮时)在出生时、儿童早期、儿童中期和青春期的后代中,b)母亲甲状腺功能的轻度缺陷,以及c)不良发育结果(如果有)是否部分归因于暴露不足子宫内的母体甲状腺激素。我们还旨在描述代谢物和母体化合物之间的关系,并检查代谢物和孕妇甲状腺功能之间的关联。拟议的研究借鉴了儿童健康与发展研究的数据,该研究对 1959 年至 1966 年间出生的儿童进行了纵向随访,这些儿童的母亲参加了加州奥克兰凯撒基金会健康计划,并扩展了之前 NIH 资助的研究。产前血清已适当冷冻和储存,可用于评估有机氯化合物代谢物的暴露情况;怀孕期间接触有机氯化合物和母亲甲状腺功能的情况已经得到测量。对同一儿童从出生到 17 岁的一系列生长测量以及 5 岁、9-11 岁和 15-17 岁的标准化发育检查都可以进行。拟议的有机氯暴露测量和母体甲状腺功能暴露测量(促甲状腺激素、游离甲状腺素和甲状腺过氧化物酶抗体)。统计分析将利用数据的重复测量结构来估计关联性。分析将采用广义估计方程(GEE)方法进行重复测量,并考虑潜在的混杂变量。我们将区分从婴儿期到青春期的产前有机氯代谢物暴露的影响。我们还将研究一种具体机制:通过母体甲状腺功能。结果将充分描述产前暴露的影响,并将进一步了解亚临床母亲甲状腺激素缺乏与儿童发育之间的关系。这一系列研究可能会导致产前干预。公共卫生相关性:我们将区分从婴儿期到青春期的产前有机氯代谢物暴露的影响。我们还将研究一种具体机制:通过母体甲状腺功能。结果将充分描述产前暴露的影响,并将进一步了解亚临床母亲甲状腺激素缺乏与儿童发育之间的关系。这一系列研究可能会导致产前干预。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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Pam R Factor-Litvak其他文献
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- 批准号:
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$ 55.26万 - 项目类别:
Training Program in Environmental Life Course Epidemiology
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$ 55.26万 - 项目类别:
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9307804 - 财政年份:2015
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$ 55.26万 - 项目类别:
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9554224 - 财政年份:2015
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8582553 - 财政年份:2012
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