Prenatal pyrethroid exposure and child mental, motor and behavioral development

产前拟除虫菊酯暴露与儿童心理、运动和行为发育

• 批准号: 8582553
• 负责人: Pam R Factor-Litvak
• 金额: $ 45.01万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-11-15 至 2016-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8582553
• 关键词: 4 year old; Affect; Age; Attention; Behavior; Behavioral; Biological Markers; Birth; Blood specimen; Characteristics; Child; Child Behavior; Child Development; Child Rearing; Clinic; Cognitive; Cohort Studies; Data; Deterioration; Development; Emotions; Enrollment; Environment; Environmental Health; Epidemiologic Studies; Equipment and supply inventories; Executive Dysfunction; Exposure to; Family; Funding; Future; Goals; Health; Home visitation; Hospitals; House Call; Hyperactive behavior; Insecticides; Intelligence; Laboratory Animals; Language; Lead; Linear Regressions; Link; Maps; Measures; Medical Records; Modeling; Mothers; Motor; Motor Skills; National Institute of Environmental Health Sciences; Neighborhoods; New York; New York City; Nursery Schools; Organophosphates; Outcome; Parents; Performance; Pest Control; Pesticides; Poverty; Pregnancy; Presbyterian Church; Process; Psyche structure; Public Health; Publishing; Questionnaires; Regression Analysis; Research; Research Infrastructure; Sampling; School-Age Population; Short-Term Memory; Smoking History; Socioeconomic Status; Spottings; Testing; Time; Toxic effect; United States Environmental Protection Agency; Update; Urine; Validation; Whole Blood; Woman; behavior rating scale; cohort; design; epidemiologic data; executive function; fetal pyrethroid exposure; follow-up; instrument; learned behavior; mental development; postnatal; prenatal; prenatal exposure; processing speed; public health relevance; pup; pyrethroid; satisfaction; social; urinary

DESCRIPTION (provided by applicant): Exposure to pyrethroid insecticides is a growing health concern due to the ban on residential use of organophosphate (OP) insecticides. Pyrethroids have replaced OP for residential pest control. Use is increasing across the U.S. and is particularly high in New York City (NYC). Experimental and preliminary epidemiologic data suggest that prenatal exposure may adversely affect child mental, motor and behavioral development. However, additionally research is urgently needed. The goals of this study are to examine whether biomarkers of prenatal exposure to pyrethroid insecticides are associated with adverse children's cognitive, motor and behavioral development. In doing so, we will also validate a urinary biomarker of prenatal exposure to these compounds for use in epidemiologic research. To accomplish this, we use data from two ongoing longitudinal birth cohorts which together comprise n=325 NYC mothers and children. Pyrethroid metabolites will be measured in urine samples collected and stored from all women during pregnancy. Between child ages 48-58 months, families will be invited to our clinic for development assessments. Cognitive development will be assessed using the Wechsler Preschool and Primary Scale of Intelligence-3rd edition; motor development using the Bruininks-OseretskyTest of Motor Proficiency, 2nd edition; and executive function using the Behavior Rating Inventory of Executive Function-Preschool Version. A home visit will be made to obtain data on the childrearing environment. Child blood samples will be collected to measure lead in whole blood. Questionnaires will be administered to the mother updating social and demographic information, smoking history, and maternal satisfaction and demoralization (the Psychiatric Epidemiology Research Instrument Demoralization Scale) and to gather data on pesticide use. Maternal intelligence will also be assessed (the Test of Non-Verbal Intelligence, 3rd edition). GIS mapping will be used to model neighborhood level SES and other characteristics which may act as a confounder in the current study. Multiple linear regression analysis will be used to examine associations between the pyrethroid metabolites and outcomes, adjusting for potential confounders and multiple comparisons. Results from this study will have immediate public health importance and will inform future studies examining pyrethroid toxicities. Indoor uses of pyrethroid insecticides have been increasing dramatically. Preliminary data suggest that prenatal pyrethroids exposure can adversely affects child learning and behavior. However, no prior study has evaluated associations between pyrethroid metabolites in maternal prenatal urine and cognitive, motor or behavioral outcomes in children.

描述（由申请人提供）：由于禁止使用有机磷酸盐（OP）杀虫剂的住宅使用，暴露于拟除虫菊酯杀虫剂是越来越多的健康问题。拟除虫菊酯已替换为住宅有害生物控制的OP。美国的使用量正在增加，在纽约市（NYC）尤其高。实验和初步的流行病学数据表明，产前暴露可能会对儿童的心理，运动和行为发展产生不利影响。但是，迫切需要研究。这项研究的目标是检查产前暴露于拟除虫菊酯杀虫剂的生物标志物是否与不良儿童的认知，运动和行为发展有关。在此过程中，我们还将验证产前暴露于这些化合物的尿生物标志物，以用于流行病学研究。为此，我们使用了两个正在进行的纵向出生队列的数据，其中包括N = 325个纽约市母亲和儿童。拟除虫菊酯代谢物将在妊娠期间从所有妇女中收集并储存的尿液样本中测量。在48-58岁的儿童之间，将邀请家庭去我们的诊所进行发展评估。认知发展将使用Wechsler幼儿园和Intelligence-3rd Edition的初级规模进行评估；使用Bruininks-Oseretskytest的运动能力开发，第二版；和执行功能，使用执行功能学位版本的行为评级清单。将进行一次家庭访问，以获取有关育儿环境的数据。将收集儿童血液样本以测量全血的铅。问卷将对母亲进行调查，以更新社会和人口统计信息，吸烟史以及孕产妇满意度和沮丧（精神病流行病学研究工具士气低落量表），并收集有关使用农药使用的数据。也将评估孕产妇智能（非语言智能的测试，第三版）。 GIS映射将用于建模社区级别的SES和其他特征，这些特征可能是当前研究中的混杂因素。多个线性回归分析将用于检查拟除虫菊酯代谢产物和结果之间的关联，调整潜在的混杂因素和多重比较。这项研究的结果将立即具有公共健康的重要性，并将为检查拟除虫菊酯毒性的未来研究提供信息。拟除虫菊酯杀虫剂的室内用途已大大增加。初步数据表明，产前拟除虫菊酯暴露会对儿童的学习和行为产生不利影响。但是，没有先前的研究评估了孕产妇尿液中的拟除虫菊酯代谢产物与儿童认知，运动或行为结果的关联。