Prenatal pyrethroid exposure and child mental, motor and behavioral development

产前拟除虫菊酯暴露与儿童心理、运动和行为发育

• 批准号: 8582553
• 负责人: Pam R Factor-Litvak
• 金额: $ 45.01万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-11-15 至 2016-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8582553
• 关键词: 4 year old; Affect; Age; Attention; Behavior; Behavioral; Biological Markers; Birth; Blood specimen; Characteristics; Child; Child Behavior; Child Development; Child Rearing; Clinic; Cognitive; Cohort Studies; Data; Deterioration; Development; Emotions; Enrollment; Environment; Environmental Health; Epidemiologic Studies; Equipment and supply inventories; Executive Dysfunction; Exposure to; Family; Funding; Future; Goals; Health; Home visitation; Hospitals; House Call; Hyperactive behavior; Insecticides; Intelligence; Laboratory Animals; Language; Lead; Linear Regressions; Link; Maps; Measures; Medical Records; Modeling; Mothers; Motor; Motor Skills; National Institute of Environmental Health Sciences; Neighborhoods; New York; New York City; Nursery Schools; Organophosphates; Outcome; Parents; Performance; Pest Control; Pesticides; Poverty; Pregnancy; Presbyterian Church; Process; Psyche structure; Public Health; Publishing; Questionnaires; Regression Analysis; Research; Research Infrastructure; Sampling; School-Age Population; Short-Term Memory; Smoking History; Socioeconomic Status; Spottings; Testing; Time; Toxic effect; United States Environmental Protection Agency; Update; Urine; Validation; Whole Blood; Woman; behavior rating scale; cohort; design; epidemiologic data; executive function; fetal pyrethroid exposure; follow-up; instrument; learned behavior; mental development; postnatal; prenatal; prenatal exposure; processing speed; public health relevance; pup; pyrethroid; satisfaction; social; urinary

DESCRIPTION (provided by applicant): Exposure to pyrethroid insecticides is a growing health concern due to the ban on residential use of organophosphate (OP) insecticides. Pyrethroids have replaced OP for residential pest control. Use is increasing across the U.S. and is particularly high in New York City (NYC). Experimental and preliminary epidemiologic data suggest that prenatal exposure may adversely affect child mental, motor and behavioral development. However, additionally research is urgently needed. The goals of this study are to examine whether biomarkers of prenatal exposure to pyrethroid insecticides are associated with adverse children's cognitive, motor and behavioral development. In doing so, we will also validate a urinary biomarker of prenatal exposure to these compounds for use in epidemiologic research. To accomplish this, we use data from two ongoing longitudinal birth cohorts which together comprise n=325 NYC mothers and children. Pyrethroid metabolites will be measured in urine samples collected and stored from all women during pregnancy. Between child ages 48-58 months, families will be invited to our clinic for development assessments. Cognitive development will be assessed using the Wechsler Preschool and Primary Scale of Intelligence-3rd edition; motor development using the Bruininks-OseretskyTest of Motor Proficiency, 2nd edition; and executive function using the Behavior Rating Inventory of Executive Function-Preschool Version. A home visit will be made to obtain data on the childrearing environment. Child blood samples will be collected to measure lead in whole blood. Questionnaires will be administered to the mother updating social and demographic information, smoking history, and maternal satisfaction and demoralization (the Psychiatric Epidemiology Research Instrument Demoralization Scale) and to gather data on pesticide use. Maternal intelligence will also be assessed (the Test of Non-Verbal Intelligence, 3rd edition). GIS mapping will be used to model neighborhood level SES and other characteristics which may act as a confounder in the current study. Multiple linear regression analysis will be used to examine associations between the pyrethroid metabolites and outcomes, adjusting for potential confounders and multiple comparisons. Results from this study will have immediate public health importance and will inform future studies examining pyrethroid toxicities. Indoor uses of pyrethroid insecticides have been increasing dramatically. Preliminary data suggest that prenatal pyrethroids exposure can adversely affects child learning and behavior. However, no prior study has evaluated associations between pyrethroid metabolites in maternal prenatal urine and cognitive, motor or behavioral outcomes in children.

描述（由申请人提供）：由于禁止住宅使用有机磷（OP）杀虫剂，接触拟除虫菊酯杀虫剂已成为一个日益严重的健康问题。拟除虫菊酯已取代 OP 用于住宅害虫防治。美国各地的使用量正在增加，其中纽约市 (NYC) 的使用量尤其高。实验和初步流行病学数据表明，产前接触可能会对儿童的智力、运动和行为发育产生不利影响。然而，迫切需要进行额外的研究。本研究的目的是检查产前接触拟除虫菊酯杀虫剂的生物标志物是否与儿童认知、运动和行为发育不良有关。在此过程中，我们还将验证产前接触这些化合物的尿液生物标志物，以用于流行病学研究。为了实现这一目标，我们使用了两个正在进行的纵向出生队列的数据，这两个队列总共包含 325 名纽约市母亲和儿童。拟除虫菊酯代谢物将从怀孕期间收集和储存的所有妇女的尿液样本中进行测量。 48-58 个月的儿童的家庭将被邀请到我们的诊所进行发育评估。将使用韦克斯勒学前和小学智力量表第三版评估认知发展；使用 Bruininks-Oseretsky 电机熟练程度测试（第二版）进行电机开发；和执行功能使用执行功能行为评定量表-学前版。将进行家访，获取有关育儿环境的数据。将收集儿童血液样本以测量全血中的铅。将对母亲进行问卷调查，更新社会和人口信息、吸烟史、母亲满意度和士气低落（精神病流行病学研究工具士气低落量表），并收集农药使用数据。还将评估母亲的智力（非语言智力测试，第三版）。 GIS 制图将用于对邻里层面的 SES 和其他特征进行建模，这些特征可能会成为当前研究中的混杂因素。多元线性回归分析将用于检查拟除虫菊酯代谢物和结果之间的关联，调整潜在的混杂因素和多重比较。这项研究的结果将具有直接的公共卫生重要性，并将为未来检查拟除虫菊酯毒性的研究提供信息。拟除虫菊酯杀虫剂的室内使用量急剧增加。初步数据表明，产前接触拟除虫菊酯会对儿童的学习和行为产生不利影响。然而，之前没有研究评估母亲产前尿液中拟除虫菊酯代谢物与儿童认知、运动或行为结果之间的关联。