Effects of a Major Climatic Event -Superstorm Sandy- on Pregnancy Outcomes and Te

重大气候事件 - 超级风暴桑迪 - 对怀孕结果和技术的影响

• 批准号: 8662273
• 负责人: Pam R Factor-Litvak
• 金额: $ 19.8万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-15 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8662273
• 关键词: Academic Medical Centers; Acute; Address; Adult; Adverse event; Anxiety; Archives; Area; Behavior; Biological; Birth; Birth Weight; Birth length; Bread; Businesses; Child; Chronic Disease; Climate; Clinic; Cognition; Cognitive; Conceptions; Delaware; Disasters; Emergency Situation; Evaluation; Event; Exposure to; Fathers; Fetal Growth; Fetal Growth Retardation; Gasoline; Gestational Age; Global Warming; Head circumference; Health behavior; Healthcare; Heart Diseases; Hormones; Housing; Hurricane; Hydrocortisone; Income; Inflammatory; Length; Leukocytes; Life; Life Style; Literature; Longevity; Maternal Exposure; Measurement; Measures; Mental Depression; Mid-Atlantic Region; Milk; Mothers; Natural Disasters; New Jersey; New York City; Newborn Infant; Outcome; Parents; Participant; Pregnancy; Pregnancy Outcome; Pregnant Women; Premature Birth; Problem behavior; Process; Production; Protocols documentation; Psychological Stress; Psychosocial Stress; Questionnaires; Recruitment Activity; Sample Size; Site; Small for Gestational Age Infant; Social support; Specimen; Staging; Stress; Stressful Event; Syndrome; Testing; Time; Transportation; Ultrasonography; United States; Vulnerable Populations; Work; cohort; depressive symptoms; experience; fetal; improved; interest; novel; post-traumatic stress; prenatal; prenatal exposure; psychosocial; public health relevance; resilience; response; stressor; telomere

DESCRIPTION (provided by applicant): Major climatic events, such as hurricanes, appear to be increasing due to the consequences of global warming. Such events are likely associated with increased psychological stress. On October 29, 2012 Superstorm Sandy, a major hurricane, devastated the mid-Atlantic region of the United States, particularly the New York City/New Jersey area. Pregnant women are considered a vulnerable population and there is increasing evidence that acute psychosocial stressors may be associated with adverse pregnancy outcomes, such as decreases in birth weight and decreases in gestational length. Further, maternal exposure to stressful events may be associated with decreases in leukocyte telomere length (LTL) in the newborn. Capitalizing on a birth cohort currently being recruited, we propose a study to examine associations between exposure to Superstorm Sandy and pregnancy outcomes and newborn LTL. This study improves on previous studies of natural and manmade disasters because we will be able to parse exposure to specific trimesters and to the three months prior to conception; we have place controls, i.e. a cohort being recruited in an unaffected area using exactly the same measures; we have baseline information on maternal perceived stress, depression, anxiety, social support and resilience, and we have an adequate sample size to address the aims. Results from this study have the potential to inform emergency responders and clinicians how best to support and potentially mitigate the effects of psychological stress among pregnant women after a major natural disaster. Results will also set the stage for studies to inquire whether prenatal exposure to stressful events is associated with cognitive and behavioral problems in children.

描述（由申请人提供）：由于全球变暖的后果，飓风等重大气候事件似乎正在增加。此类事件可能与心理压力增加有关。 2012 年 10 月 29 日，超级飓风桑迪摧毁了美国大西洋中部地区，特别是纽约市/新泽西地区。孕妇被认为是弱势群体，越来越多的证据表明，急性社会心理压力可能与不良妊娠结局有关，例如出生体重下降和孕期缩短。此外，母亲接触压力事件可能与新生儿白细胞端粒长度（LTL）的减少有关。利用目前正在招募的出生队列，我们​​提出了一项研究，以检验超级风暴桑迪暴露与妊娠结局和新生儿 LTL 之间的关联。这项研究改进了之前对自然灾害和人为灾害的研究，因为我们将能够解析特定妊娠期和受孕前三个月的暴露情况；我们有地方控制，即使用完全相同的措施在未受影响的地区招募一批人；我们有关于母亲感受到的压力、抑郁、焦虑、社会支持和复原力的基线信息，并且我们有足够的样本量来实现这些目标。这项研究的结果有可能告诉紧急救援人员和临床医生如何最好地支持和减轻重大自然灾害后孕妇心理压力的影响。结果还将为研究奠定基础，以探究产前暴露于压力事件是否与儿童的认知和行为问题有关。