Small Animal Imaging

小动物成像

• 批准号: 7491891
• 负责人: JAMEY P WEICHERT
• 金额: $ 15.17万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-23 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7491891
• 关键词: Anatomy; Anesthesia procedures; Animal Model; Animals; Arts; Beds; Biological; Cells; Consultations; Contrast Media; Coupled; Data Set; Detection; Evaluation; Gases; Hybrids; Image; Isoflurane; Manufacturer Name; Methodology; Mission; Modality; Physiologic Monitoring; Proteins; Radiochemistry; Radiolabeled; Range; Rattus; Research; Research Personnel; Resolution; Rodent; Scanning; Schedule; System; Technology; detector; in vivo; innovation; member; radiotracer; reconstruction; small molecule; tumor

The UWCCC Small Animal Imaging Facility provides innovative, state-of-the-art, affordable, noninvasive, high-resolution in-vivo and ex-vivo imaging support to UWCCC members who utilize small animal models in their research. The facility director and manager provide consultation with investigators about methodologies most suited to answer their biological questions. Investigators are able to select various levels of support ranging from image acquisition alone, to acquisition and reconstruction, to image interpretation and finally to media presentation. Because of their radiochemistry expertise, they also radiolabel small molecules or proteins for investigators prior to imaging. Anatomic MicroCT Scanning. A MicroCAT-2 from Siemens/CTI is equipped with a large field-of-view detector, thus allowing high resolution scanning (18 micron)'of rats up to 300 grams. The system is equipped with a rodent isoflurane gas anesthesia system and physiologic monitoring system which allows image gating, Functional MicroPET Scanning. Functional microPET imaging is also available. Because both scanners are from the same manufacturer, the scanning beds are completely interchangeable which allows scanning with both modalities without moving the animal, thus allowing fairly accurate fusion of the two data sets. We are scheduled to acquire the first commercial microCT/microPET hybrid scanner from Siemens/CTI in June of 2006. This world's first hybrid scanner coupled with our own proprietary cell-selective imaging and contrast agents affords our investigators unique tumor detection and evaluation technologies which can only be provided here.

UWCCC小型动物成像设施提供创新的，最先进的，负担得起的，无创的， 高分辨率在体内和前体内成像支持UWCCC成员，他们利用小动物模型 他们的研究。设施主管兼经理向调查人员提供有关调查人员的咨询 方法最适合回答其生物学问题。调查人员能够选择各种 支持水平的水平，从单独获取，获取和重建到图像等级 解释，最后是媒体演示。由于他们的放射化学专业知识，他们也 在成像之前，用于研究人员的辐射标记小分子或蛋白质。 解剖微分扫描。来自西门子/CTI的Microcat-2配备了大型视野 检测器，从而允许高分辨率扫描（18微米）'的大鼠最多300克。该系统配备了 使用啮齿动物异氟硫富气体麻醉系统和生理监测系统，该系统允许图像 门控， 功能性微型扫描。还可以使用功能性微型材料成像。因为两个扫描仪 来自同一制造商，扫描床完全可以互换，可以进行扫描 两种模态都没有移动动物，因此可以相当准确地融合两个数据集。 我们计划从西门子/CTI中获取第一个商业Microct/Micropet混合动力扫描仪 2006年6月。这个世界上第一个混合扫描仪，加上我们自己的专有细胞选择成像和 对比剂为我们的研究人员提供独特的肿瘤检测和评估技术，只能 在这里提供。