Smart sensor for guiding safe delivery of anesthetic and pain drugs through epidurals

智能传感器用于指导通过硬膜外麻醉剂和止痛药物的安全输送

基本信息

批准号：
10545953
负责人：
NICUSOR IFTIMIA
金额：
$ 25.85万
依托单位：
PHYSICAL SCIENCES, INC
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-01 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10545953
关键词：
3D Print Adhesives Anatomy Anesthetics Animal Model Animals Birth Blindness Brachytherapy Catheters Cervical Chemicals Chronic neck pain Clinical Clinical Investigator Collaborations Computer software Cystic Lesion Development Device or Instrument Development Devices Drug Delivery Systems Dura Mater Engineering Epidural Anesthesia Epidural Injections Evaluation Excision Failure Family suidae Fluoroscopy Goals Government Headache Health Healthcare Systems Helping to End Addiction Long-term Hospital Costs Hospitals Human Image Infection Interferometry Israel Laboratories Ligaments Measures Monitor Movement Nature Needles Operative Surgical Procedures Optics Pain Pain Clinics Pain management Paralysed Patient-Focused Outcomes Patients Persons Pharmaceutical Preparations Phase Positioning Attribute Procedures Puncture procedure Resistance Resolution Secondary to Secure Slipped Disk Specialist Specimen Spinal Stenosis Spine surgery Stroke Syndrome Syringes Techniques Technology Testing Tissues Training Vertebral column Woman Work animal tissue base chronic pain comparative discogenic pain epidural space improved in vivo instrument instrumentation interstitial ligamentum flavum member meter migration nerve damage new technology novel novel strategies physical science pre-clinical pressure prevent programs prototype response sensor sensor technology side effect standard of care success therapy development

3D Print Adhesives Anatomy Anesthetics Animal Model Animals Birth Blindness Brachytherapy Catheters Cervical Chemicals Chronic neck pain Clinical Clinical Investigator Collaborations Computer software Cystic Lesion Development Device or Instrument Development Devices Drug Delivery Systems Dura Mater Engineering Epidural Anesthesia Epidural Injections Evaluation Excision Failure Family suidae Fluoroscopy Goals Government Headache Health Healthcare Systems Helping to End Addiction Long-term Hospital Costs Hospitals Human Image Infection Interferometry Israel Laboratories Ligaments Measures Monitor Movement Nature Needles Operative Surgical Procedures Optics Pain Pain Clinics Pain management Paralysed Patient-Focused Outcomes Patients Persons Pharmaceutical Preparations Phase Positioning Attribute Procedures Puncture procedure Resistance Resolution Secondary to Secure Slipped Disk Specialist Specimen Spinal Stenosis Spine surgery Stroke Syndrome Syringes Techniques Technology Testing Tissues Training Vertebral column Woman Work animal tissue base chronic pain comparative discogenic pain epidural space improved in vivo instrument instrumentation interstitial ligamentum flavum member meter migration nerve damage new technology novel novel strategies physical science pre-clinical pressure prevent programs prototype response sensor sensor technology side effect standard of care success therapy development

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项目摘要

Project Summary/Abstract Physical Sciences Inc. (PSI), in collaboration with anesthesiologists from Beth Israel Deaconess (BID) Hospital and Brigham and Women’s Hospital (BWH), who will act as consultants in Phase I and clinical investigators in Phase II, proposes to develop a novel approach for guiding safer delivery of pain and/or anesthetic drugs during epidural procedures (EPs). Epidural injections are typically used to treat pain from herniated discs, spinal stenosis, chemical discs, chronic pain secondary to post-cervical surgery syndrome, and chronic neck pain of discogenic origin. They are also regularly used to alleviate pain related to birth. However, when not properly performed, the epidural injections can have negative side effects, such as severe headache, infection, and even nerve damage. Serious side effects may also occur, including stroke, paralysis, or loss of vision. A new technology based on a novel optical sensing technique is proposed to assess tissue composition and optimize the force applied to the needle to guide its safe insertion into the epidural space, while the monitoring of the pulsatile pressure in the epidermal space is proposed for evaluating proper positioning of the drug delivery catheter. The Phase I effort will focus on development of a laboratory prototype that will be initially tested and optimized ex vivo on animal tissue specimens, and then preliminarily evaluating its efficacy in vivo in swine. Based on the Phase I findings, the technology will be further improved during Phase II and validated on humans at BWH.

项目摘要/摘要物理科学公司（PSI），与贝丝以色列执事（BID）的麻醉师合作医院和杨百翰医院（BWH），她将在第一阶段和临床上担任顾问第二阶段的研究人员，提出了一种新型方法，以指导更安全的疼痛和/或硬膜外程序期间的麻醉药（EPS）。硬膜外注射通常用于治疗椎间盘突出，脊柱狭窄，化学椎间盘，继发后手术综合征的慢性疼痛，和椎间盘起源的慢性颈部疼痛。它们还定期用于减轻与出生有关的疼痛。但是，如果执行未正确执行，硬膜外注射可能会产生负面影响，例如可能还会发生严重的副作用，包括中风瘫痪或视力丧失。提出了一种基于新型的光学传感技术来评估组织组成的新技术并优化施加到针上的力以引导其安全插入硬膜外空间，而提出了对表皮空间中脉动压力的监测，以评估适当的定位药物输送导管。第一阶段的努力将集中于开发实验室原型最初在动物组织标本上测试并优化了体内，然后初步评估其有效性在猪中体内。根据I阶段发现，该技术将在第二阶段和在BWH上对人类进行了验证。