Integrating optical coherence tomography with laryngeal high-speed videoendoscopy

光学相干断层扫描与喉高速视频内窥镜集成

基本信息

批准号：
8647260
负责人：
NICUSOR IFTIMIA
金额：
$ 22.5万
依托单位：
PHYSICAL SCIENCES, INC
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-01-01 至 2015-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8647260
关键词：
Address Anatomy Animals Anterior Appearance Clinical Collaborations Data Data Analyses Devices Dimensions Disease Endoscopes Engineering Ensure Epithelial Evaluation General Hospitals Government Human Image Imagery Imaging technology Lamina Propria Laryngoscopes Larynx Lateral Light Massachusetts Measures Modality Modeling Monitor Motion Operative Surgical Procedures Optical Coherence Tomography Optics Otolaryngology Patients Performance Persons Phase Phonation Preclinical Testing Production Property Qualifying Research Resolution Rest Scanning Scientist Shapes Slice Source Specimen Speed Structure Superficial Lesion Surface System Technology Testing Time Tissues Treatment outcome Validation Voice Voice Disorders base design improved in vivo instrument kinematics multidisciplinary operation physical science programs prototype public health relevance research study signal processing success vibration vocal cord

项目摘要

DESCRIPTION (provided by applicant): There is a growing clinical need for improving the assessment of vocal fold tissue properties in vivo, especially dynamic properties measured during human voice production. To address this need, Physical Sciences Inc. (PSI), in collaboration with MGH Voice Center, will develop a clinically-viable imaging system that will integrate optical coherence tomography (OCT) with laryngeal high-speed videoendoscopy (HSV). A transoral endoscope will be developed to assess surface appearance, surface shape, and sub-epithelial anatomy of vocal fold tissue at rest and during phonation. Phase I bench-top testing on fresh calf larynges will include empirical validation of spatial and temporal alignment and optimization of the field of view for each modality. The PSI/MGH team will perform data analysis and assessment of the results to continue to develop effective ways of visualizing the vocal folds using the different modes of system operation. A clinical prototype is proposed to be developed in Phase II and tested on human patients.

描述（由申请人提供）：越来越多的临床需求来改善体内人声折叠组织特性的评估，尤其是在人类语音生产过程中测得的动态特性。为了满足这一需求，物理科学公司（PSI）与MGH语音中心合作，将开发一个可行的临床成像系统，该系统将将光学相干断层扫描（OCT）与喉高速视频镜检查（HSV）集成。将开发横向内窥镜，以评估静止和发声过程中声带组织的表面外观，表面形状和下皮下皮解剖结构。第一阶段的基准测试对新鲜小牛喉部进行的测试将包括对每种模式的空间和时间对齐的经验验证以及视野的优化。 PSI/MGH团队将对结果进行数据分析和评估，以继续使用系统操作的不同模式来开发有效的人声折叠方式。提出临床原型将在II期开发并对人类患者进行测试。