Smart sensor for guiding safe delivery of anesthetic and pain drugs through epidurals

智能传感器用于指导通过硬膜外麻醉剂和止痛药物的安全输送

• 批准号: 10883933
• 负责人: NICUSOR IFTIMIA
• 金额: $ 3.58万
• 依托单位: PHYSICAL SCIENCES, INC
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10883933
• 关键词: Anesthetics; Animals; Birth; Blindness; Cervical; Characteristics; Chemicals; Chronic neck pain; Engineering; Epidural Injections; Fiber; Headache; Health; Hospitals; Human; Infection; Interferometry; Laboratories; Light; Monitor; Needles; Noise; Operative Surgical Procedures; Optics; Pain; Pain Clinics; Paralysed; Patient-Focused Outcomes; Pharmaceutical Preparations; Phase; Procedures; Secondary to; Slipped Disk; Source; Specimen; Spinal Stenosis; Stroke; Syndrome; Technology; Testing; Tissue Differentiation; Tissues; United States National Institutes of Health; animal tissue; chronic pain; cost; discogenic pain; epidural space; experimental study; improved; nerve damage; new technology; novel; novel strategies; physical science; prototype; sensor; side effect

Project Summary/Abstract Physical Sciences Inc. (PSI) proposes to develop a novel approach for guiding safer delivery of pain and/or anesthetic drugs during epidural procedures (EPs). Epidural injections are typically used to treat pain from herniated discs, spinal stenosis, chemical discs, chronic pain secondary to post-cervical surgery syndrome, and chronic neck pain of discogenic origin. They are also regularly used to alleviate pain related to birth. However, when not properly performed, the epidural injections can have negative side effects, such as severe headache, infection, and even nerve damage. Serious side effects may also occur, including stroke, paralysis, or loss of vision. This proposal aims to overcome current issues related to epidural injections by using a novel and more reliable low coherence interferometry (LCI) optical sensing approach to determine what tissue type is present at the tip of the needle, while monitoring the force applied to the needle to safely pass it into the epidural space using a fiber Bragg sensor. During the Phase I effort PSSI has developed a laboratory prototype for epidural guidance that combines low coherence interferometry with Bragg sensing within the same probe. This approach was tested and optimized ex vivo on animal tissue specimens. Although feasibility was demonstrated, the differentiation of tissue types was somewhat impeded by the relatively high intensity noise of the light source owed by PSI and used in the experiments. Therefore, we request NIH support to purchase a better performing light source, as well as to cover the nonrecurring engineering cost of suitable Bragg gratings that better match the spectral characteristics of this light source. After improving the setup, the technology will be evaluated in live animals. Based on the Phase I findings, the technology will be further improved during Phase II and validated on humans at BWH.

项目摘要/摘要 物理科学公司（PSI）提议开发一种新颖的方法来指导更安全的疼痛交付 硬膜外程序（EPS）期间的麻醉药物和/或麻醉药。硬膜外注射通常用于治疗疼痛 从椎间盘突出，脊柱狭窄，化学椎间盘，继发后手术的慢性疼痛中 综合征和椎间盘起源的慢性颈部疼痛。它们也经常用于减轻与疼痛有关的 出生。但是，如果没有正确执行，硬膜外注射可能会产生负面影响，例如 严重的头痛，感染甚至神经损伤。也可能发生严重的副作用，包括 中风，瘫痪或视力丧失。 该建议旨在通过使用小说以及更多的更多信息来克服与硬膜外注射有关的当前问题 可靠的低相干干涉法（LCI）光传感方法来确定存在哪种组织类型 在针头的尖端，在监视施加到针上的力以安全地将其传递到硬膜外 使用纤维bragg传感器的空间。 在第一阶段的努力中，PSSI开发了用于硬膜外指导的实验室原型 在同一探针中与Bragg感测的低相干干涉法。这种方法已被测试， 在动物组织标本上优化了体内。尽管证明了可行性，但 PSI欠的光源的相对较高的强度噪声在某种程度上阻碍了组织类型 并在实验中使用。因此，我们要求NIH支持购买更好的性能光源， 以及涵盖合适的布拉格光栅的非重新工程成本，可以更好地匹配光谱 此光源的特征。改进设置后，将在活动物中评估该技术。 根据I阶段的发现，该技术将在II期期间进一步改进，并在 人类在BWH。