ROBUST DETECTION OF OCULAR DOMINANCE IN HUMANS BOLD 7 T

对人类优势眼的稳健检测 BOLD 7 T

• 批准号: 7721384
• 负责人: ESSA YACOUB
• 金额: $ 7.13万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7721384
• 关键词: Architecture; Blood Vessels; Brain; Cells; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Cortical Column; Data; Felis catus; Functional Magnetic Resonance Imaging; Funding; Grant; Hand; Human; Institution; Knowledge; Maps; Methodology; Monkeys; Neocortex; Ocular Dominance; Ocular dominance columns; Pattern; Physiological; Process; Property; Rattus; Relative (related person); Research; Research Personnel; Resources; Signal Transduction; Source; Structure; System; United States National Institutes of Health; Visual Cortex; base; blood oxygen level dependent; day; gray matter; human subject; magnetic field; research study; sensory cortex

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cells in the mammalian brain tend to be grouped together according to their afferent and efferent connectivity, as well as their physiological properties. The columnar structures of neocortex are prominent examples of such modular organization, and have been studied extensively in anatomical and physiological experiments in rats, cats and monkeys. The importance of noninvasive study of such structures, in particular in human subjects, cannot be overemphasized. Not surprisingly, therefore, many attempts were made to map cortical columns using functional magnetic resonance imaging (fMRI). Yet, the robustness, repeatability, and generality of the hitherto used fMRI methodologies have been a subject of intensive debate. Using differential mapping in a high magnetic field magnet (7 T), we demonstrate here the ability of Hahn Spin-Echo (HSE) BOLD to map the ocular dominance columns (ODCs) of the human visual cortex reproducibly over several days with a high degree of accuracy, relative to expected spatial patterns from post-mortem data. On the other hand, the conventional Gradient-Echo (GE) blood oxygen level dependent (BOLD) signal in some cases failed to resolve ODCs uniformly across the selected gray matter region, due to the presence of non-specific signals. HSE signals uniformly resolved the ODC patterns, providing a more generalized mapping methodology (i.e. one that does not require adjusting experimental approaches based on prior knowledge or assumptions about functional organization and vascular structure in order to avoid confounding large vessel effects) to map unknown columnar systems in the human brain, potentially paving the way both for the study of the functional architecture of human sensory cortices, and of brain modules underlying specific cognitive processes.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 哺乳动物大脑中的细胞倾向于根据其传入和传出的连通性及其生理特性将其分组在一起。新皮层的柱状结构是这种模块化组织的重要例子，并且在大鼠，猫和猴子的解剖学和生理实验中进行了广泛的研究。对这种结构的无创研究的重要性，尤其是在人类受试者中，不能过分强调。因此，毫不奇怪，进行了许多尝试使用功能磁共振成像（fMRI）绘制皮质柱的尝试。然而，迄今使用的fMRI方法的鲁棒性，可重复性和普遍性一直是一项激烈争论的主题。在高磁场磁铁中使用微分映射（7 t），我们在这里演示了Hahn Spin-Echo（HSE）Bold绘制人类视觉皮层的眼部优势柱（ODC）的能力，该曲线在几天内以高度的准确性重复地重复地绘制了与后验证后数据相对于预期的空间模式的相对性。另一方面，由于存在非特异性信号，在某些情况下，常规的梯度回声（GE）血氧水平取决于（BOLD）信号（BOLD）信号（BOLD）信号无法在所选的灰质区域均匀解析ODC。 HSE信号均匀解析了ODC模式，提供了一种更普遍的映射方法（即，一种不需要根据先验知识或有关功能组织和血管结构的假设调整实验方法的方法，以避免使大脑中的构图和型号的构造构造的特定方式，以避免构图构图，以绘制人的大脑中的特定方式，以使其具有特定的形式。认知过程。