FMRI ABILITY TO MAP COLUMNAR STRUCTURES IN HUMANS

FMRI 绘制人体柱状结构的能力

• 批准号: 8170453
• 负责人: ESSA YACOUB
• 金额: $ 2.57万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170453
• 关键词: Animal Model; Animals; Brain; Computer Retrieval of Information on Scientific Projects Database; Cortical Column; Development; Functional Magnetic Resonance Imaging; Funding; Grant; Human; Institution; Maps; Modeling; Research; Research Personnel; Resolution; Resources; Source; Specificity; Structure; Techniques; United States National Institutes of Health; millimeter; orientation columns

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. During the past 4 years, we have challenged the limits of BOLD fMRI to the level of sub-millimeter structures (i.e. cortical columns) in humans and laminar specificity in the animal model. We have established that SE BOLD technique at high fields is more suitable for mapping columnar structures. Our strategy of employing high-field SE BOLD contrast has allowed us to explore, in addition to ODCs, orientation columns in the human brain, which were previously unmapped. Here, we will develop new capabilities for larger volume coverage for high-resolution fMRI acquisitions in humans as well as continued application and development of a high resolution animal fMRI model.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 在过去的四年中，我们对人类和动物模型中人类和层状特异性的次数少量结构（即皮质柱）的限制提出了质疑。我们已经确定，高场的SE Bold技术更适合于映射柱状结构。我们采用高档SE对比度的策略使我们能够探索以前未映射的人脑中的ODC和方向柱。在这里，我们将开发新的功能，以供人类高分辨率功能磁共振成像获取以及持续应用和开发高分辨率动物fMRI模型的较大容量覆盖。