SPATIAL SPECIFICITY OF HIGH-RESOLUTION, SPIN-ECHO BOLD AND CBF FMRI AT 7T

7T 下高分辨率、Spin-Echo BOLD 和 CBF FMRI 的空间特异性

• 批准号: 7721358
• 负责人: ESSA YACOUB
• 金额: $ 3.57万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7721358
• 关键词: Address; Animals; Blood; Communication; Computer Retrieval of Information on Scientific Projects Database; Core-Binding Factor; Functional Magnetic Resonance Imaging; Funding; Grant; Human; Image; Institution; Letters; Maps; Publishing; Research; Research Personnel; Resolution; Resources; Signal Transduction; Source; Specificity; United States National Institutes of Health; Voice; Weight; base; response; Address; Animals; Blood; Communication; Computer Retrieval of Information on Scientific Projects Database; Core-Binding Factor; Functional Magnetic Resonance Imaging; Funding; Grant; Human; Image; Institution; Letters; Maps; Publishing; Research; Research Personnel; Resolution; Resources; Signal Transduction; Source; Specificity; United States National Institutes of Health; Voice; Weight; base; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In his letter, Dr. Duyn expresses concerns regarding the spatial specificity of our spin-echo (SE) BOLD and CBFbased functional mapping signals (1) because of inherent T*2 weighting in EPI images, blood contributions to SE BOLD, and BOLD effects in CBF-based fMRI. Detailed verification or discussion of these points was beyond the scope of our article (1), since it was submitted as a Note (although published as a Communication) addressing technical issues of high-resolution SE BOLD and CBF fMRI in humans at 4 and 7 T where EPI confronts major diffi- culties. Consequently, our remarks on the spatial specificity of fMRI were based on animal studies at high fields (2,3). However, the issues voiced by Dr. Duyn were indeed mentioned in the original article (1), and were fully dealt with in two articles published shortly afterwards (4,5). Our responses to Dr. Duyn?s three points are summarized below.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 杜恩博士在信中表达了有关 我们的自旋回波（SE）粗体和基于CBF的空间特异性 功能映射信号（1）由于固有 t*2在EPI图像中加权，对SE的血液贡献 基于CBF的fMRI中的大胆和大胆效果。详细的 对这些观点的验证或讨论超出了 我们的文章（1）的范围，因为它是作为注释提交的 （尽管作为交流出版）解决 高分辨率SE Bold和CBF fMRI的技术问题 在4和7 t的人类中，EPI面对主要的差异 文化。因此，我们对空间特异性的评论 fMRI的基于高场的动物研究 （2,3）。但是，杜林博士提出的问题确实是 在原始文章（1）中提到，并完全处理 不久之后发表了两篇文章（4,5）。我们的 下面总结了对Duyn博士的三点的回应。