Core--Library design and analysis

核心--文库设计与分析

• 批准号: 7553315
• 负责人: DAVID G VANDERVELDE
• 金额: $ 7.64万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7553315
• 关键词: biomedical facility; combinatorial chemistry; high throughput technology; mass spectrometry; nuclear magnetic resonance spectroscopy; technology /technique development

The Library Design and Analysis Core Laboratory (LDA laboratory, Core C) is responsible for assisting with the design of diverse libraries and carrying out the spectroscopic characterization of library members. The specific aims of the LDA core laboratory are as follows: Specific Aim 1. The LDA core laboratory will provide the research projects and Synthesis core laboratory with the computational facilities for managing chemical structures and data, for predicting key physicochemical properties of compounds to be synthesized, and for guiding the design of diverse libraries. Specific Aim 2. The LDA core laboratory will provide automated, high throughput mass spectrometry and NMR analysis to confirm the identity and purity of compounds in libraries.

图书馆设计和分析核心实验室（LDA实验室，核心C）负责 协助设计不同的图书馆并执行图书馆成员的光谱表征。 LDA核心实验室的具体目的如下：特定目的1。LDA核心实验室将为研究项目和合成核心实验室提供用于管理化学结构和数据的计算设施，以预测要合成的化合物的关键物理化学性质，并构成多种图书馆的设计。特定目标2。LDA核心实验室将提供自动化的高吞吐量质谱和NMR分析，以确认库中化合物的身份和纯度。