Avance II 500 High Performance Digital NMR Spectrometer System

Avance II 500 高性能数字核磁共振波谱仪系统

• 批准号: 7389182
• 负责人: DAVID G VANDERVELDE
• 金额: $ 46.81万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-25 至 2008-09-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7389182
• 关键词: Alzheimer' s Disease; Bacteria; Chemicals; Core Facility; Disease; Faculty; Funding; Future; Health; Human; Institutes; Kansas; Malignant Neoplasms; Methods; Nuclear Magnetic Resonance; Pain; Peptides; Performance; Pharmaceutical Preparations; Property; Research; Sampling; Science; Specificity; System; United States National Institutes of Health; Universities; Virus; digital; improved; instrument; member; protein structure; small molecule; tool

DESCRIPTION (provided by applicant): In this proposal, a group of eight faculty members in the chemical sciences at the University of Kansas are requesting a shared 500 megahertz nuclear magnetic resonance (NMR) spectrometer. They all receive funding from various institutes of the NIH. A major theme within the group is developing better ways to synthesize small druglike molecules, or improve the specificity and potency of biologically active compounds which may be drug leads. Other research within the group includes bioactive peptides which may have applications in improved pain relief, and determining the structures of proteins from disease-causing bacteria and viruses. NMR is a key tool to characterize the new compounds being made, verify their identity, and understand their properties. The proposed instrument would become part of a core facility in which nearly 38,000 small molecule samples were analyzed in the last year, and timely access to results has become a significant limitation on the ongoing research. The relevance of the research the proposed instrument would support to human health is in the new druglike compounds being made here and the new methods for making them, which will be applied both here and elsewhere in the future. Some compounds are targeted for very specific applications against cancer or Alzheimer's disease; others are made more broadly to be screened against many targets relevant to disease states.

描述（由申请人提供）：在该提案中，堪萨斯大学化学科学的八名教职员工要求共享500兆赫核磁共振（NMR）光谱仪。他们都从NIH的各个机构获得资金。该小组中的一个主要主题是开发更好的方法来合成小型药物样分子，或提高可能是药物铅的生物活性化合物的特异性和效力。该组中的其他研究包括可能在改善疼痛缓解疼痛方面应用的生物活性肽，并确定引起疾病的细菌和病毒的蛋白质结构。 NMR是表征正在制作的新化合物，验证其身份并了解其特性的关键工具。拟议的仪器将成为核心设施的一部分，该设施在去年分析了近38,000个小分子样本，及时访问结果已成为对正在进行的研究的重要限制。拟议工具将支持人类健康的研究的相关性是在这里制造的新型药物般的化合物以及制造它们的新方法，这些方法将在未来和其他地方应用。一些化合物针对针对癌症或阿尔茨海默氏病的非常特殊的应用。其他人则更广泛地筛选了许多与疾病状态相关的目标。

项目成果

Enabling Surgical Placement of Hydrogels Through Achieving Paste-Like Rheological Behavior in Hydrogel Precursor Solutions.

• DOI: 10.1007/s10439-015-1277-8
• 发表时间: 2015-10
• 期刊: Annals of biomedical engineering
• 影响因子: 3.8
• 作者: Beck EC;Lohman BL;Tabakh DB;Kieweg SL;Gehrke SH;Berkland CJ;Detamore MS
• 通讯作者: Detamore MS

Human Toll-like receptor 8-selective agonistic activities in 1-alkyl-1H-benzimidazol-2-amines.

• DOI: 10.1021/jm500701q
• 发表时间: 2014-09-11
• 期刊: Journal of medicinal chemistry
• 影响因子: 7.3
• 作者: Beesu M;Malladi SS;Fox LM;Jones CD;Dixit A;David SA
• 通讯作者: David SA

One-pot synthesis of GABA amides via the nucleophilic addition of amines to 3,3-disubstituted cyclopropenes.

• DOI: 10.1039/c5ob01462j
• 发表时间: 2015-09-14
• 期刊: Organic & biomolecular chemistry
• 影响因子: 3.2
• 作者: Maslivetc VA;Rubina M;Rubin M
• 通讯作者: Rubin M

Palladium-Catalyzed Stereospecific Decarboxylative Benzylation of Alkynes.

• DOI: 10.1021/acs.orglett.5b02410
• 发表时间: 2015-10
• 期刊: Organic letters
• 影响因子: 5.2
• 作者: Shehani N. Mendis;J. Tunge

Photocatalytic Aminodecarboxylation of Carboxylic Acids.

• DOI: 10.1002/ejoc.201600620
• 发表时间: 2016-07
• 期刊: European journal of organic chemistry
• 影响因子: 2.8
• 作者: Lang SB;Cartwright KC;Welter RS;Locascio TM;Tunge JA
• 通讯作者: Tunge JA