Chem Library Screening Core

化学库筛选核心

• 批准号: 7127459
• 负责人: HOWARD S FOX
• 金额: $ 35.78万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7127459
• 关键词: biomedical facility; chemical registry /resource; combinatorial chemistry; high throughput technology

The Chem Library Screening Core of the Scripps NeuroAIDS Preclinical Studies (SNAPS) Center will facilitate the screening of diverse chemical libraries in the context of research relevant to neuroAIDS. Numerous investigators at TSRI have generated libraries and are eager to collaborate with biologists/biochemists working on defined biological systems. The major mission of the proposed Core will be to facilitate such interactions by development of a series of high through-put screens and aid in the development of specialized screens as the need arises. Both biochemical and cell-based screening assays will be developed and employed to identify discrete mixtures of compounds that interfere with viral protein function(s) and interrupt the virus life cycle and/or virus penetration of the CNS. The Library Screening Core will interact with a very diverse group of investigators, integrating their expertise and creating additional know-how for the screening of compounds. The ultimate goal will be to aid in identification of specific lead compounds to aid in development of anti-virals effective against Neuro-AIDS.

Scripps Neuroaids临床前研究（SNAPS）中心的化学库筛选核心将 在与神经辅助相关的研究背景下，促进筛查各种化学图书馆。 TSRI的许多调查人员已经生成了图书馆，并且渴望与 生物学家/生物化学家从事定义的生物系统。提议的核心的主要任务将 通过开发一系列高透明屏幕来促进这种相互作用，并有助于 随着需求的出现的开发。生化和基于细胞的筛查测定法 将开发和使用以识别干扰病毒蛋白的化合物的离散混合物 功能（S）并打断CNS病毒生命周期和/或病毒穿透。图书馆筛选核心 将与一个非常多样化的调查人员互动，整合他们的专业知识并创建其他 筛选化合物的知识。最终目标是帮助识别特定的铅 有助于开发有效针对神经辅助的抗病毒的化合物。