UNMC Training Program in Alzheimer’s Disease and Related Dementias Drug Discovery

UNMC 阿尔茨海默病和相关痴呆药物发现培训计划

• 批准号: 10411479
• 负责人: HOWARD S FOX
• 金额: $ 16.27万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10411479
• 关键词: Alzheimer' s disease related dementia; Training Programs; drug discovery

Abstract With a critical need to establish a workforce of specialists in neurodegenerative diseases focusing on Alzheimer’s disease, there is an increasing demand for multidisciplinary scientists in the biomedical research community. Despite this significant need, there are few training programs that provide experience in academic and clinical settings. This proposal for an Alzheimer’s Disease and Related-Dementia Drug Discovery training program is critical to meeting that increased demand. The overall goal of this program is to fund five predoctoral students from the Colleges of Pharmacy and Medicine to become experienced leaders in interdisciplinary research with the ability to collaborate effectively on cross-disciplinary teams with broad expertise to address challenges within target-based drug discovery. The program will help the selected students to develop keen scientific rigor and translational skills necessary to compete and excel in the future workplace, including but not limited to academic institutions, government agencies, for-profit businesses, and private foundations. Importantly, the program faculty are drawn from a wide array of disciplines with many active collaborations. Twelve mentors are dedicated to this training program, all either tenured or in tenure track positions, with the experience and funding to undertake their training and mentoring roles. These faculty will provide trainees with a unique program in which to learn techniques and methodologies of collaborative research projects. The proposed training program is composed of formal didactic courses, discussion-based journal clubs and seminars, shadowing of a clinician and mentored research leading to a doctoral thesis and Ph.D. degree within 5.5 years of entering graduate school. This innovative program will produce an outstanding output of trainees with high accomplishments that will in turn catalyze our recruitment of the best students for this interdisciplinary training program at the University of Nebraska Medical Center.

抽象的 迫切需要建立针对阿尔茨海默氏症的神经退行性疾病专家的劳动力 疾病，生物医学研究界对多学科科学家的需求不断增长。 尽管有很大的需求，但很少有培训计划提供学术和临床方面的经验 设置。这项关于阿尔茨海默氏病和相关诱因药物发现培训计划的建议是 满足增加需求的至关重要。该计划的总体目标是资助五名五名学生 从药房和医学学院成为跨学科研究经验丰富的领导者 有效地与具有广泛专业知识的跨学科团队合作的能力，以应对内部的挑战 基于目标的药物发现。该计划将帮助选定的学生发展敏锐的科学严谨性和 在未来的工作场所中竞争和出色所必需的翻译技能，包括但不限于学术 机构，政府机构，营利性企业和私人基金会。重要的是，该程序 教师是从许多积极合作的各种学科中得出的。十二位导师是敬业的 对于这个培训计划，所有任期或任期轨道职位都有经验和资金 承担他们的培训和心理角色。这些教师将为受训者提供一个独特的计划 学习协作研究项目的技术和方法。拟议的培训计划是 由正式的教学课程，基于讨论的期刊俱乐部和半岛座组成，临床和 指导的研究导致博士学位论文和博士学位。进入研究生院5.5年之内。 这个创新的计划将使受训者的出色成就具有很高的成就 转向催化我们在大学的跨学科培训计划中招募最好的学生 内布拉斯加州医疗中心。