NNTC Data Coordinating Center

NNTC数据协调中心

• 批准号: 8843966
• 负责人: HOWARD S FOX
• 金额: $ 80.51万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-03 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8843966
• 关键词: AIDS/HIV problem; Address; Aging; Animal Model; Archives; Autopsy; Bioinformatics; Biometry; Blood; Book Chapters; Brain; Cerebrospinal Fluid; Clinical; Clinical Data; Clinical Research; Clinical assessments; Collaborations; Communication; Communities; Confidentiality; Consequences of HIV; Data; Data Base Management; Data Coordinating Center; Data Set; Data Sources; Databases; Diagnosis; Disease; Ensure; Epidemiology; Equipment and supply inventories; Fostering; Foxes; Goals; Grant; HIV; HIV Infections; HIV therapy; HIV-associated neurocognitive disorder; Highly Active Antiretroviral Therapy; Housing; Human; Immunologics; In Vitro; Information Systems; Instruction; Knowledge; Knowledge Discovery; Laboratories; Leadership; Learning; Libraries; Link; Liquid substance; Medical; Metadata; Modeling; Neurodegenerative Disorders; Neurologic; Organ; Outcome; Patients; Peer Review; Peripheral Nervous System; Privacy; Public Relations; Publications; Quality Control; Recording of previous events; Reporting; Request for Applications; Research; Research Infrastructure; Research Personnel; Resources; Role; Science; Services; Specimen; Structure; System; Testing; Time; Tissues; United States National Institutes of Health; Voting; Work; abstracting; brain tissue; clinical research site; cohort; data acquisition; data sharing; design; follow-up; human disease; improved; innovation; knowledge base; meetings; member; neuroAIDS; operation; research study; tissue resource; tool; web site

DESCRIPTION (provided by applicant): The project supports the Data Coordinating Center (DCC) to the National NeuroAIDS Tissue Consortium (NNTC). The NNTC is a resource for investigators conducting NeuroAIDS research to identify the neuropathogenic mechanisms involved In HIV disease of the central and peripheral nervous systems. The consortium is composed of four NNTC Clinical Sites and one DCC that work cooperatively as a resource for the research community, providing HIV/AIDS Investigators with clinically annotated datasets of antemortem Information and associated postmortem tissue and fluids. The DCC provides the NNTC with scientific leadership, management expertise, bioinformatics and Information systems infrastructure, statistical and epidemiology expertise, and serves as a voting member of the NNTC Steering Committee. The DCC works cooperatively with the NNTC Clinical Sites to provide (1) management and database capabilities to ensure effective clinical and brain banking operations and (2) scientific expertise in biostatistics and HIV epidemiology to support broad analyses of the NNTC clinical database and analyses that support the recruitment and retention goals for the cohort. The NNTC has produced over 380 peer-reviewed publications, over 175 abstracts/book chapters/presentations, as well as supporting the work on numerous researchers' grants. The DCC serves as the point of contact for users of the resource (tissue and/or data requests) and services the requests from the time they are submitted through fulfillment of the request and follow up with the requestor to provide the results of their researc. The NNTC website is used extensively for dissemination of resource Information (query tools, reports, request applications) and management tasks such as resource tracking, document libraries, and communication activities. An inventory of all specimens housed at each NNTC Clinical Site will be maintained, as will be databases generated with additional research data beyond clinical assessments such as bioinformatics datasets by the users of the resource. The DCC promotes the NNTC through public relations materials including a comprehensive website and meeting presentations. RELEVANCE (See instructions): The NNTC has served as a valuable resource to the NeuroAIDS research community since 1998. Its continuation is critical given the need for quality CNS tissues and related antemortem clinical data. Investigators using these resources examine emerging research topics in the NeuroAIDS field such as: a) eradication of HIV from persistent CNS reservoirs; b) pathogenic mechanisms of HIV-associated neurocognitive disorders (HAND) in setting of long term HAART; and c) HIV and aging.

描述（由申请人提供）：该项目支持国家神经辅助组织（NNTC）的数据协调中心（DCC）。 NNTC是进行神经辅助研究的研究人员的资源，以识别中枢神经系统和周围神经系统中涉及的HIV疾病的神经病机制。该财团由四个NNTC临床站点和一个DCC组成，它们合作作为研究界的资源，为艾滋病毒/艾滋病研究人员提供了临床注释的动物质地信息的数据集以及相关的后死后组织和流体。 DCC为NNTC提供了科学领导，管理专业知识，生物信息系统和信息系统基础设施，统计和流行病学专业知识，并担任NNTC指导委员会的投票成员。 DCC与NNTC临床站点合作，提供（1）管理和数据库功能，以确保有效的临床和大脑银行业务，以及（2）生物统计学和HIV流行病学方面的科学专业知识，以支持NNTC临床数据库的广泛分析，并分析支持该人群的招聘和重新启动目标。 NNTC已生产了380多种经过同行评审的出版物，超过175篇摘要/书籍章节/演示文稿，并支持许多研究人员的赠款。 DCC是资源用户（组织和/或数据请求）的联系点，并为通过履行请求提交的请求提供服务，并与请求者进行跟进以提供其研究结果。 NNTC网站广泛用于传播资源信息（查询工具，报告，请求应用程序）和管理任务，例如资源跟踪，文档库和通信活动。将维护每个NNT​​C临床部位所容纳的所有标本的清单，这将由资源的用户使用临床评估（例如生物信息学位数据集）生成的其他研究数据。 DCC通过公共关系材料（包括全面的网站和会议演示文稿）促进NNTC。相关性（请参见说明）：自1998年以来，NNTC一直是神经辅助研究社区的宝贵资源。鉴于需要优质的CNS组织和相关的Antemortem临床数据，它的延续至关重要。使用这些资源的研究人员检查了神经辅助领域的新兴研究主题，例如：a）从持久的中枢神经系统水库中消除HIV； b）长期HAART的艾滋病毒相关神经认知障碍（手）的致病机制；和c）艾滋病毒和衰老。